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Home › Conditions › Stress Urinary Incontinence

Stress Urinary Incontinence

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Stress Urinary Incontinence

58 trials tracked for Stress Urinary Incontinence: 11 in phase 3 or 4 and 8 with published results. The most-cited published study has 148 citations.

58Trials tracked
11Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 3 Phase 3 8 Phase 2 8 Phase 1 1 Other / NA 38
  1. Phase 3 ATLAS: Ambulatory Treatments for Leakage Associated With Stress Completed · 148 cited
  2. Phase 3 Combined Treatment for Mixed Incontinence Completed · 83 cited
  3. Phase 3 Study Comparing TVT With TVT-SECUR for the Treatment of Stress Urinary Incontinence Completed · 74 cited
  4. Phase 3 Autologous Muscle Derived Cells for Female Urinary Sphincter Repair Completed · 44 cited
  5. Phase 3 Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery Completed · 30 cited
  6. Phase 3 Sling vs Botox for Mixed Incontinence Completed · 13 cited
Show 44 more trials
  1. Phase 3 Autologous Muscle Derived Cells Female Stress Urinary Incontinence Clinical Study Completed · 12 cited
  2. Phase 4 The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence Completed · 10 cited
  3. Phase 4 Trial Liposomal Bupivacaine Following Retropubic Suburethral Sling for Stress Urinary Incontinence Completed
  4. Phase 4 The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling Completed
  5. Phase 3 Platelet-Rich Plasma for Stress Urinary Incontinence Completed
  6. Phase 2 Safety and Efficacy Study on the Implantation of the Tension-Free Vaginal Tape (TVT-Secur) Under Local Anesthesia Completed
  7. Phase 2 GTx-024 as a Treatment for Stress Urinary Incontinence in Women Completed
  8. Phase 2 An Investigation of the Safety of 4 Different Doses of Autologous Muscle Derived Cells as Therapy for Stress Urinary Incontinence Completed
  9. Phase 2 Gentamicin Intravesical Efficacy for Infection of Urinary Tract Completed
  10. Phase 2 Exploratory Trial of TAS-303 in Female Patients With Stress Urinary Incontinence Completed
  11. Phase 2 Evaluation Of The Ability Of Fesoterodine To Increase Urethral Pressure In Stress Urinary Incontinence Patients Completed
  12. Phase 2 Study to Assess Enobosarm (GTx-024) in Postmenopausal Women With Stress Urinary Incontinence Completed
  13. Phase 2 Autologous Cell Therapy for Female Stress Urinary Incontinence Completed
  14. Phase 1 Does Single Dose Imipramine Affect the Opening Pressure of the Urethral and Anal Sphincter? Completed
  15. N/A Comparing KIM to TVT Exact Sling Completed
  16. N/A Stress Incontinence Trial With Elitone Device Completed
  17. N/A Artificial Urinary Sphincter Clinical Outcomes Completed
  18. N/A Time Interval Between TVT and First Void (TIBT) Study Completed
  19. N/A Randomized Control Trial to Assess Postoperative Pain After Sling Placement Completed
  20. N/A A Post-Market Study of the AMS AdVance™ Male Sling System for the Treatment of Male Stress Urinary Incontinence Completed
  21. N/A Efficacy of Electroacupuncture (EA) for Women With Pure Stress Urinary Incontinence (SUI) Completed
  22. N/A AMS AdVance and AdVance XP Male Sling Systems for the Treatment of Stress Urinary Incontinence Following Prostatectomy: Evaluation of Safety, Efficacy, and Quality of Life Through Retrospective Chart Review and Prospective Follow-up Completed
  23. N/A Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled Trial Completed
  24. N/A A Randomized Controlled Trial of the Uresta Continence Pessary Completed
  25. N/A Group Learning Achieves Decreased Incidents of Lower Urinary Symptoms Completed
  26. N/A Preliminary Performance Study of the New TIPI Device in the Prevention of Stress Urinary Incontinence Completed
  27. N/A Laser Therapy for Treatment of Urogenital Symptoms in Women Completed
  28. N/A A Group-Based Therapeutic Yoga Intervention for Urinary Incontinence in Ambulatory Older Women Completed
  29. N/A Comparison of the Viveve Treatment and Cryogen-Only Treatment Versus Sham Treatment for Stress Urinary Incontinence Completed
  30. N/A The Altis® Single Incision Sling System for Female Stress Urinary Incontinence Study Completed
  31. N/A Systematized Quality Exercise Alternatives for Stress Incontinence Completed
  32. N/A The Prefyx PPS™ System eRegistry Completed
  33. N/A Transobturator Verus Single Incision Slings Completed
  34. N/A TVT-SECUR as an Office-based Procedure Completed
  35. N/A LIBERATE International Completed
  36. N/A RCT on Multimodal Self-treatment for Women With Incontinence Using a Digital Health Application Completed
  37. N/A A Clinical Study to Assess the Safety of a Disposable Intra-vaginal Device for Stress Urinary Incontinence Completed
  38. N/A Educating Women About Pelvic Floor Disorders During Pregnancy Completed
  39. N/A Timing of Repeat Voiding Trials After Outpatient Pelvic Floor Surgery Completed
  40. N/A Retropubic vs. Single-Incision Mid-Urethral Sling for Stress Urinary Incontinence Completed
  41. N/A A Pilot Clinical Study of the Efficacy and Safety of a Disposable Intravaginal Device for Stress Urinary Incontinence Completed
  42. N/A Disposable Stress Urinary Incontinence Pessary Device Study Completed
  43. N/A Use of the Leva Incontinence System in Treating Bladder Incontinence. Completed
  44. N/A Post Market Study Of Single Incision Sling Versus Transobturator Sling for Stress Urinary Incontinence Completed

Showing the 50 most-cited and recently-updated of 58 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Stress Urinary Incontinence: what the trials found

Several surgical and procedural interventions have been evaluated for Stress Urinary Incontinence (SUI). A midurethral sling demonstrated significant reductions in UDI total scores (-138.8 to -147.7), stress scores (-69.3 to -73.8), and irritative scores (-49.5 to -53.5) 5. Tension-free vaginal tape was evaluated, showing a subjective cure rate of 72% to 77% at 12 months 6, though patient global impression improvements were not statistically significant 6. The AMDC-USR procedure showed response rates of 82% and 90% at 12 months 10.

Pharmacological and injectable treatments show varying results. Botox injections resulted in reductions in UDI-LF total scores (-63.1 to -89.1), stress scores (-20.2 to -46.4), and irritative scores (-28.1 to -40.8) 9. Iltamiocel was associated with a 50% reduction in SUI episode frequency in 103 participants compared to 52 in the comparison group at 12 months 7, with 73 vs 30 achieving a 75% reduction 7. Behavioral therapy showed significant improvement, with 59-80 patients reporting 'Much Better' or 'Very Much Better' on PGI-I at both 3 and 12 months 4, and 49-71 patients reporting no bothersome SUI symptoms at 3 months 4.

Other interventions include lidocaine with epinephrine 1, liposomal bupivacaine (which showed a significant reduction in 'Pain in the Morning' from 9.5 to 27.0, p=0.014) 3, and platelet-rich plasma injections 11. The GTx-024 treatment was associated with an 81% mean percent change in SUI episodes per day and a 71% mean percent change in pad weight 14.

Recent results — preliminary, needs further review

  • Intravenous fluid administration showed a significant difference in residual bladder volume (141 vs 42, p=0.02) 21.
  • Laparoscopic Burch Colposuspension was evaluated as an intervention 22.

For the clinician treating this condition

  • Surgical interventions like midurethral slings and AMDC-USR show consistent improvements in UDI scores and response rates.
  • Behavioral therapy is associated with significant patient-reported improvement in SUI symptoms at 3 and 12 months.
  • Injectable treatments (Botox, Iltamiocel) and specific pharmacological agents (GTx-024) show measurable impacts on incontinence frequency and score reductions.

AI synthesis of 12 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
EMG biofeedback assisted pelvic floor training improves muscle strength and reduces incontinence severity
Rheumatology Meta-analysis
EMG biofeedback assisted pelvic floor training improves muscle strength and reduces incontinence severity Biofeedback training shows some benefits for stress urinary incontinence
This meta-analysis of 1,045 women with stress urinary incontinence found that EMG-BF supported PFMT leads to a small reduction in incontinen…
Adding biofeedback to pelvic floor exercises may improve muscle strength and quality of life for women dealing with stress urinary incontine…
Frontiers Jul 18, 2026
Autologous regenerative cell therapy shows 41% cure rate and 55% improvement rate for stress urinary incontinence
Genetics & Precision Medicine Meta-analysis
Autologous regenerative cell therapy shows 41% cure rate and 55% improvement rate for stress urinary incontinence Cell therapy shows promise for stress urinary incontinence
This systematic review and meta-analysis of 591 patients found pooled cure and improvement rates of 41% and 55% for autologous regenerative …
A new analysis finds that regenerative cell therapy may help women with stress incontinence, with 41% cured and 55% improved.
Frontiers Jun 4, 2026
Electroacupuncture with Pelvic Floor Training Reduces Stress Urinary Incontinence Leakage
Anesthesiology & Pain Medicine RCT
Electroacupuncture with Pelvic Floor Training Reduces Stress Urinary Incontinence Leakage Two Treatments Beat Surgery for Leaky Bladders
In this randomized controlled trial of 128 women with mild-to-moderate stress urinary incontinence, combining electroacupuncture with pelvic…
Combining electroacupuncture with pelvic floor muscle training reduced urine leakage more than either treatment alone for women with stress …
NEJM Apr 18, 2026
Resting-state fMRI shows brain activity differences in women with functional constipation and stress urinary incontinence
Neurology Cohort
Resting-state fMRI shows brain activity differences in women with functional constipation and stress urinary incontinence Does stress incontinence and constipation change how your brain works?
A cohort study of 34 female patients with functional constipation and stress urinary incontinence (FCon-SUI), 24 with functional constipatio…
Women with both constipation and incontinence show unique brain activity patterns linked to movement control and visual processing that diff…
Frontiers Apr 14, 2026