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Home › Conditions › Functional Constipation

Functional Constipation

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Functional Constipation

11 trials tracked for Functional Constipation: 7 in phase 3 or 4 and 3 with published results. The most-cited published study has 51 citations.

11Trials tracked
7Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 1 Phase 3 6 Phase 2 4
  1. Phase 3 Lubiprostone in Children With Functional Constipation Completed · 51 cited
  2. Phase 3 Lubiprostone for Children With Constipation Completed · 51 cited
  3. Phase 3 Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC) Completed · 30 cited
  4. Phase 4 The Effect of Probiotics on Constipation, and Intestinal Microflora in Children With Functional Constipation Completed
  5. Phase 3 Evaluation of the Safety of Lubiprostone in Pediatric Participants Aged ≥ 6 Years to < 18 Years With Functional Constipation Completed
  6. Phase 3 Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C Completed
Show 5 more trials
  1. Phase 3 Prucalopride in Pediatric Subjects With Functional Constipation Completed
  2. Phase 2 Linaclotide Safety and Efficacy in 2 to 5-Year-Old Participants With Functional Constipation Completed
  3. Phase 2 A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide Completed
  4. Phase 2 Dose-ranging Efficacy of Polydextrose Supplement on Colonic Transit Time and Symptoms in Adults With Functional Constipation Completed
  5. Phase 2 Effect of Ileal Bile Acid Transporter Inhibitor in Functional Constipation Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Resting-state fMRI shows brain activity differences in women with functional constipation and stress urinary incontinence
Neurology Cohort
Resting-state fMRI shows brain activity differences in women with functional constipation and stress urinary incontinence Does stress incontinence and constipation change how your brain works?
A cohort study of 34 female patients with functional constipation and stress urinary incontinence (FCon-SUI), 24 with functional constipatio…
Women with both constipation and incontinence show unique brain activity patterns linked to movement control and visual processing that diff…
Frontiers Apr 14, 2026
Pelvic floor physiotherapy improves quality of life and reduces painful defecation in pediatric functional constipation
Pediatrics Meta-analysis
Pelvic floor physiotherapy improves quality of life and reduces painful defecation in pediatric functional constipation When Laxatives Are Not Enough, This Therapy May Help Kids
This meta-analysis of seven randomized controlled trials involving 775 pediatric and adolescent participants assessed pelvic floor physiothe…
For children whose constipation will not budge on laxatives alone, targeted pelvic floor therapy eased pain and boosted quality of life acro…
Apr 13, 2026
Network meta-analysis suggests Chinese patent medicines plus Western medicine may improve functional constipation in elderly
Infectious Disease Meta-analysis
Network meta-analysis suggests Chinese patent medicines plus Western medicine may improve functional constipation in elderly Chinese herbal medicines combined with Western drugs may help elderly constipation
A network meta-analysis of 23 RCTs involving 2065 elderly patients with functional constipation found that six Chinese patent medicines comb…
Adding specific Chinese herbal medicines to standard Western drugs may improve overall treatment response for elderly constipation, though e…
Frontiers Apr 2, 2026

Questions about Functional Constipation

Are there brain activity differences between women with functional constipation and stress urinary incontinence?

Women with functional constipation and stress urinary incontinence show different brain activity patterns compared to those with constipation alone, particularly in areas controlling movement and emotion.

Full answer →
Does pelvic floor physiotherapy reduce painful defecation in pediatric functional constipation patients?

Pelvic floor physiotherapy reduces painful defecation and improves quality of life in children with functional constipation, though results on how often they poop are mixed.

Full answer →
Does resting-state fMRI show brain activity differences in women with functional constipation?

Resting-state fMRI shows that women with functional constipation have different brain activity patterns compared to healthy people, and these patterns differ further if they also have stress urinary incontinence.

Full answer →