Post-hoc ATTEND trial analysis shows stroke severity and caregiver factors predict 6-month outcomes in India.
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Key Takeaway
Note that baseline disability, age, caregiver type, and treatment location associate with 6-month stroke outcomes in this Indian cohort.
This post-hoc analysis of a multicentre, prospective, randomised, open blinded endpoint trial included 1,250 randomised participants, of whom 1,156 had sufficient data for analysis. The setting comprised 14 hospitals in India. The primary outcome was the modified Rankin Scale (mRS) assessed at baseline, 3 months, and 6 months. The intervention or exposure was not reported as this was a post-hoc analysis of the ATTEND trial, and the comparator was not reported.
The mean change in mRS between baseline and 3 months was -0.96 (SD 1.40). The mean change between 3 months and 6 months was -0.30 (SD 0.83). Additionally, 66.7% of patients improved on stroke symptoms at 3 months compared to baseline, and 34% improved at 6 months compared to 3 months.
Higher mRS scores at 6 months were associated with age 40-60 years versus <40 years (OR 1.84, 95% CI 1.16 - 2.93) and age >60 years versus <40 years (OR 2.83, 95% CI 1.69 - 4.75). Caregiver type also mattered, with a daughter or daughter-in-law as main caregiver versus spouse showing an OR of 1.44 (95% CI 1.01 - 2.06). Being dependent at home versus independent was associated with an OR of 4.93 (95% CI 1.61 - 15.14).
Treatment location showed significant associations. Treatment in Kerala versus Delhi had an OR of 3.52 (95% CI 2.13 - 5.81), while treatment in Tamil Nadu versus Delhi had an OR of 2.76 (95% CI 1.74 - 4.37). Treatment in Assam versus Delhi had an OR of 2.43 (95% CI 1.35 - 4.37). Treatment in Chandigarh versus Delhi had an OR of 1.93 (95% CI 1.05 - 3.55), and treatment in Hyderabad versus Delhi had an OR of 2.00 (95% CI 1.12 - 3.58). Lower mRS scores at 6 months were associated with not having disability at baseline (OR 0.19, 95% CI 0.12 - 0.30) and lower NIHSS scores. Safety data, adverse events, and discontinuations were not reported. Funding or conflicts were not reported. Causality cannot be inferred from this post-hoc analysis.
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View Original Abstract ↓
BACKGROUND: Functional recovery after stroke remains poor in India. However, only few data exist on stroke recovery using the modified Rankin Scale (mRS). We aimed to assess patterns and predictors of stroke recovery from a cohort of participants with acute stroke of mild to moderate severity in India.
METHODS: Post-hoc analysis of the Family-led Rehabilitation after Stroke in India (ATTEND), a multicentre, prospective, randomised, open blinded endpoint (PROBE) trial conducted at 14 hospitals in India. Data were obtained on the modified Rankin Scale (mRS) at baseline, 3 and 6 months. A multivariable partial proportional logistic regression model was used to identify the predictors of recovery after stroke and reported as odds ratio (aOR) and 95% confidence intervals (CI).
RESULTS: Of 1,250 randomised participants, 1156 had sufficient data for analysis. Overall, the severity of mRS decreased over time; the mean change in mRS [mean (SD] was- 0.96 (1.40) between baseline and 3 months and -0.30(0.83) between 3 months and 6 months. Overall, 66.7% improved on their stroke symptoms at 3 months compared to baseline. Further, 34% improved their stroke symptoms at 6 months compared to 3 moths. A higher mRS score at 6 months was associated with participants aged 40-60 years (1.84, 95% CI 1.16 - 2.93), and >60 years (2.83, 1.69 - 4.75) at stroke onset compared to those aged <40 years, having daughter or daughter in law (1.44, 1.01 - 2.06) as the main caregiver compared to spouse, being dependent at home (4.93, 1.61 - 15.14) compared to being independent at home, and receiving treatment in Assam (2.43, 1.35 - 4.37), Kerala (3.52, 2.13 - 5.81), Tamil Nadu (2.76, 1.74 - 4.37), Chandigarh (1.93, 1.05 - 3.55), and Hyderabad (2.00, 1.12 - 3.58) compared to Delhi. Regarding clinical variables, not having disability (>3 mRS) at baseline (0.19, 0.12 - 0.30), and lower stroke severity scores: NIHSS 0 - <5 (0.07, 0.04 - 0.12), 5 - <10 (0.20, 0.13 - 0.30) and 10 - <15 (0.59, 0.39 - 0.88) compared to higher scores (≥15) were associated with lower mRS scores at 6 months.
CONCLUSIONS: Nearly 67% of patients recovered at 3 months compared to baseline, consistent with previous research. Additional follow-up at six months showed that 48% sustained their previous functional status and 34% reported improvement between 3 and 6 months. These findings also highlight that both demographic and clinical factors significantly influence recovery outcomes in patients with mild to moderate stroke severity.
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