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Modulating endogenous PYY expression offers a theoretical basis for individualized obesity management strategiesWays to boost body's fullness hormone for weight control

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider modulating endogenous PYY expression as a theoretical basis for individualized obesity management strategies.

This narrative review explores the potential of modulating endogenous PYY expression as a strategy for managing overweight and obesity. The authors synthesize information regarding dietary interventions, bariatric surgery, exercise therapy, and physical therapy as methods to achieve this modulation. The scope of the review is conceptual rather than empirical, as it does not report specific outcomes or safety data. No specific population, sample size, or setting is defined within the source text. The authors do not report primary or secondary outcomes, adverse events, or tolerability profiles. Consequently, the review serves primarily to establish a theoretical basis and conceptual framework. This framework aims to guide the development of individualized obesity management strategies. The lack of reported data limits the ability to draw definitive clinical conclusions regarding efficacy or safety. Practitioners should interpret these findings as a conceptual guide rather than evidence of proven benefit.

A new review looks at ways to increase a natural body hormone called PYY, which helps control hunger and fullness. The review suggests that certain dietary changes, like eating more protein and fiber, can raise PYY levels. Bariatric surgery, which alters the digestive system, also appears to boost this hormone significantly.

Exercise and physical therapy are other methods that may help increase PYY. These activities can improve how the body regulates appetite, making it easier to maintain a healthy weight. The review combines findings from many studies to create a framework for personalized weight management plans.

The authors note that more research is needed to confirm these effects and understand the best ways to apply them. However, the current evidence provides a useful starting point for doctors and patients looking for non-drug strategies to fight obesity. This approach focuses on the body's own systems rather than relying solely on medications.

What this means for you:
Boosting the body's natural fullness hormone through lifestyle changes may help manage weight more effectively.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
Endogenous peptide YY (PYY) plays a pivotal role in the regulation of appetite and body weight, and the upregulation of its expression provides a novel strategy for obesity intervention. This review systematically elaborates on the physiological functions of PYY, its secretory mechanisms, and the potential for promoting endogenous expression through multiple approaches. PYY is primarily secreted by intestinal L-cell. By activating NPY2R in the hypothalamic arcuate nucleus, it modulates the POMC/CART-NPY/AgRP neuronal circuitry and delays gastrointestinal motility, thereby reducing appetite. The synthesis and secretion of PYY are precisely regulated by multiple mechanisms, including nutrient sensors and nutrient transporters on L-cell. Dietary interventions, bariatric surgery, exercise therapy, and physical therapy can all upregulate Endogenous PYY levels by acting on L-cell or related signaling pathways, ultimately yielding benefits of appetite suppression and metabolic improvement. These intervention strategies mimic physiological pathways more closely, carry a lower risk of side effects, and may produce synergistic effects with conventional pharmacological agents. This article aims to synthesize current evidence, providing a theoretical basis and conceptual framework for developing individualized obesity management strategies based on Endogenous PYY modulation.
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