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Creatine supplementation increases anaerobic power in healthy men regardless of resistance training statusCreatine plus resistance training builds lean mass in young men

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Key Takeaway
Consider creatine with resistance training for lean mass gains; anaerobic power benefits may occur independently.

This systematic review and meta-analysis examined the effects of creatine supplementation on body composition, maximal strength, and exercise performance. The analysis included 39 eligible trials involving healthy men aged 18–30 years. The intervention involved creatine supplementation compared against resistance training versus non-resistance training conditions.

Regarding body composition, creatine combined with resistance training resulted in significant gains in fat-free mass (FFM) of +3.39 kg and lean body mass (LBM) of +2.70 kg. In contrast, no significant gains were observed for FFM and LBM in non-resistance training conditions.

Anaerobic performance metrics showed consistent improvements across both training contexts. Wingate peak power increased by +71.27 W, and Wingate mean power increased by +39.69 W. Countermovement jump (CMJ) demonstrated a pooled improvement of 2.87 cm.

Safety data, adverse events, and tolerability were not reported in the included studies. A key limitation was high heterogeneity for the CMJ outcome (I² = 88.5%), suggesting the estimate should be interpreted with caution. While exploratory analyses suggested more consistent effects may occur in interventions lasting at least 8 weeks, the overall certainty remains exploratory. The practice relevance suggests creatine in association with resistance training is recommended for lean mass gains, while anaerobic performance benefits could be obtained in different training modalities.

Researchers analyzed data from 39 eligible trials to understand how creatine supplementation affects body composition, maximal strength, and exercise performance. The participants were healthy men between 18 and 30 years old who engaged in either resistance training or non-resistance training activities. The study found that when creatine was taken alongside resistance training, participants gained significantly more fat-free mass and lean body mass compared to those without creatine. In terms of power, creatine supplementation increased peak and mean power during anaerobic tests like the Wingate test, showing benefits even without resistance training. The analysis also noted improvements in jump height across the pooled data.

No safety concerns or adverse events were reported in the included studies, suggesting creatine is well-tolerated in this context. However, the estimate for jump height improvements showed high heterogeneity, meaning the results varied widely across studies and should be interpreted with caution. The main reason to be careful is that the benefit for body composition depends heavily on doing resistance training at the same time. Readers should realistically take from this that creatine is a useful tool for building muscle when paired with lifting, but it may not improve jump performance consistently for everyone.

What this means for you:
Creatine with resistance training increases lean mass in young men, while power gains occur regardless of training type.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
BackgroundCreatine is a highly marketed ergogenic aid that has strengthening and high-intensity training effects. However, past meta-analyses have often grouped together heterogeneous training modalities, and it was not known if the training context has a modifying effect on body composition and performance.MethodsThis systematic review and meta-analysis pooled RCT evidence in healthy men aged 18–30 years old to quantify the effects of creatine supplementation in terms of body composition, maximal strength, and exercise performance. All the databases were searched up to 1 October 2025, and 39 eligible trials were discovered. The context of training was prespecified—RT vs. non-RT, and used as the main comparison. Pooled estimates were made using random effects models for FFM, LBM, and Wingate peak and mean power, CMJ, and 1RM outcomes. The exploratory subgroup analyses were done to investigate whether training condition and intervention duration moderated the effects.ResultsThe number of trials that were considered according to the inclusion criteria was thirty-nine. When using RT, creatine supplementation led to significant gains in FFM (+3.39 kg) and LBM (+2.70 kg), but not to significant gains in non-RT conditions. Wingate peak and mean power both increased in both contexts (peak power +71.27 W; mean power +39.69 W), with no evidence that training context modified these results. CMJ showed a pooled improvement of 2.87 cm; however, this estimate should be interpreted with caution due to high heterogeneity (I2 = 88.5%). Exploratory analyses suggested that more consistent effects may occur in interventions lasting at least 8 weeks.ConclusionThe supplementation with creatine leads to an increase in anaerobic power regardless of the training environment, but the gains in body composition depend on parallel RT. In practice, creatine in association with RT is recommended for lean mass gains, while either anaerobic performance benefit could be obtained in different training modalities.Systematic review registrationThe study was prospectively registered in PROSPERO (CRD420261283973). The registration URL is: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=1283973.
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