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Unilateral Extrapedicular and Bilateral Transpedicular Approaches in Percutaneous KyphoplastyOne-sided approach for spine fracture repair may be safer

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Key Takeaway
UEA-PKP provides comparable clinical outcomes to BTA-PKP while reducing operative time, radiation exposure, and cement leakage.

This exploratory systematic review and meta-analysis evaluated the efficacy and safety of the unilateral extrapedicular approach (UEA) compared to the standard bilateral transpedicular approach (BTA) in patients with osteoporotic vertebral compression fractures. The analysis included data from 394 patients across multiple studies.

Clinical outcomes, including Oswestry Disability Index scores, Visual Analog Scale scores, kyphotic correction, and vertebral height restoration, showed no significant differences between the two techniques. This suggests that both methods are equally effective in improving patient mobility and anatomical restoration of the affected vertebrae.

However, procedural metrics favored the UEA technique. Patients undergoing UEA-PKP experienced significantly shorter operative durations and lower radiation exposure compared to those receiving BTA-PKP. Additionally, the UEA group demonstrated a lower cement volume and a reduced rate of cement leakage.

While these findings suggest that UEA may offer logistical and safety advantages during surgery, the evidence is limited by the reliance on a small number of retrospective cohort studies. Clinicians should interpret these results as exploratory when deciding on surgical techniques for vertebral compression fractures.

How this fits prior evidence

This meta-analysis addresses gaps in surgical technique comparisons for osteoporotic vertebral compression fractures. It extends the evidence regarding leakage reduction previously noted in PCKP versus UPKP, as this study specifically identifies a lower cement leakage rate (OR 0.49; 95% CI: 0.28 to 0.85) with the unilateral extrapedicular approach. Like the prior coverage of PVP, these findings are based on retrospective data and should be viewed as exploratory.

For people with painful spine fractures caused by osteoporosis, a common procedure called kyphoplasty can help. Doctors inject bone cement into the broken vertebra to stabilize it. Usually, they go in from both sides of the spine. But a new analysis suggests that a one-sided approach might be just as good and possibly safer.

The analysis looked at 394 patients from several past studies. It compared the standard two-sided method with a one-sided technique called the unilateral extrapedicular approach. The results showed that both methods worked equally well for pain relief, disability, and restoring spine height.

But the one-sided approach had some clear advantages. It took about 8 minutes less time, exposed patients to less radiation, used less cement, and had a lower risk of cement leaking out of the bone. Cement leakage can be a serious complication if it gets into the wrong place.

However, this analysis is based on a limited number of older studies that were not randomized. So the findings are considered exploratory. More research is needed before doctors change their standard practice. If you have a spine fracture, talk to your doctor about which approach might be best for you.

What this means for you:
One-sided kyphoplasty may reduce radiation and cement leakage while working as well as the two-sided method.

Common questions

What is the unilateral extrapedicular approach?

It is a one-sided needle technique used in kyphoplasty to repair spine fractures. Instead of inserting needles from both sides of the spine, the doctor goes in from one side only. The new analysis suggests it may be safer and faster than the standard two-sided method.

Is the one-sided approach as effective as the two-sided method?

According to this analysis, yes. Both approaches showed comparable results for pain relief, disability scores, and restoration of spine height. The one-sided method also had advantages like shorter surgery time and less radiation exposure.

What are the risks of cement leakage in kyphoplasty?

Cement leakage can occur when the bone cement escapes from the vertebra into surrounding tissues. It may cause nerve compression, pain, or other complications. The analysis found that the one-sided approach had a lower cement leakage rate compared to the two-sided method.

Should I ask my doctor about the one-sided approach?

This analysis is exploratory and based on limited studies. While the results are promising, more research is needed. Discuss with your doctor whether the one-sided approach might be suitable for your specific fracture and health condition.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
BackgroundSevere osteoporotic vertebral compression fractures (OVCFs) may require uniform and symmetrical cement distribution to achieve adequate biomechanical stability. Evidence for the unilateral extrapedicular approach (UEA) in percutaneous kyphoplasty (PKP) is limited. This study compares the safety and efficacy of UEA vs. bilateral transpedicular approach (BTA) in PKP for OVCFs.MethodsProspective and retrospective studies comparing UEA and BTA in PKP were identified through searches of Web of Science, PubMed, Embase, Scopus, and the Cochrane Library. Studies published through January 2026 were included. The study was performed using R version 4.5.1 with the meta package.ResultsFour studies, including 394 OVCF patients, were analyzed. UEA-PKP and BTA-PKP demonstrated comparable efficacy in Oswestry Disability Index score, Visual Analog Scale score, kyphotic correction, and vertebral height restoration. However, relative to BTA-PKP, UEA-PKP results in shorter operative duration (MD = −8.43, 95% CI: −10.90 to −5.96), reduced radiation exposure (MD = −7.23, 95% CI: −11.31 to −3.15), lower cement volume (MD = −0.94, 95% CI: −1.57 to −0.32), and is associated with lower cement leakage rate (OR = 0.49, 95% CI: 0.28–0.85).ConclusionUEA-PKP may offer safety advantages while maintaining similar efficacy compared with BTA-PKP. However, these findings should be interpreted as exploratory, as they are based exclusively on a limited number of retrospective cohort studies.
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