This observational study looked at microRNAs in women aged 40 to 64 years who were part of the Diabetes Prevention Program. The researchers wanted to understand factors that might explain the co-occurrence of type 2 diabetes and depression.
They found that specific microRNAs, including miR-320a and miR-320c, were associated with increased odds of being assigned to a high-risk profile. A cluster of these microRNAs was also significantly linked to this higher risk. Additionally, Black race was associated with at least threefold higher odds compared to other races.
The study used statistical models to determine these associations. Researchers controlled for multiple comparisons to ensure accuracy. However, the study notes that sex- and age-specific studies on these underlying factors are currently limited. Because this was an observational study, the findings show links but do not prove that these microRNAs cause the conditions. Readers should view these markers as potential tools for risk stratification rather than proven causes or treatments.