This case report describes the treatment of two patients who developed Brucella-induced infections in their knee joints after total knee replacement surgery. These infections are rare and often occur in people living in or visiting livestock-farming regions where Brucella bacteria are found in animals.
The doctors treated one patient with chronic infection using a combination of ceftriaxone sodium and doxycycline. The other patient with acute infection received Debridement and implant retention surgery followed by ceftriaxone sodium and rifampicin. Both patients had their inflammatory markers return to normal levels and their Brucella test titers decreased to the normal range.
After at least 12 months of follow-up, both patients had their knee joint range of motion restored. No adverse events or safety concerns were reported in this small group of patients. This report serves as a reference for diagnosing and treating such rare infections, though the small number of patients means these results cannot be applied broadly to all patients.