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Home › Medications › doxycycline

doxycycline

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of doxycycline

42 trials tracked of doxycycline: 23 in phase 3 or 4 and 11 with published results. The most-cited published study has 177 citations.

42Trials tracked
23Phase 3 & 4
0Recruiting
11With published results
Phase distribution
Phase 4 16 Phase 3 7 Phase 2 11 Other / NA 8
  1. Phase 4 Lipids of the Human Tear Film and Their Effect on Tear Stability Completed · 177 cited
  2. Phase 4 Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP Completed · 119 cited
  3. Phase 4 Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM Completed · 81 cited
  4. Phase 4 The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment Completed · 76 cited
  5. Phase 4 Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans Completed · 36 cited
  6. Phase 4 Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis. Completed · 11 cited
Show 36 more trials
  1. Phase 3 A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea. Completed · 10 cited
  2. Phase 3 A Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea (MVOR-2) Completed · 10 cited
  3. Phase 4 Daily Doxycycline to Inform Sexually Transmitted Infection Prophylaxis Regimens Completed
  4. Phase 4 Combo-PEP: Multipurpose Prevention of Post-Exposure Prophylaxis Regimens Completed
  5. Phase 4 Doxy-Post-exposure Prophylaxis Completed
  6. Phase 4 Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis Completed
  7. Phase 4 Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population Completed
  8. Phase 4 NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial Completed
  9. Phase 4 Weekly Doxycycline DOT for STI Prevention Among Cisgender Women Taking HIV PrEP in Kisumu, Kenya Completed
  10. Phase 4 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed
  11. Phase 4 Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo Completed
  12. Phase 4 Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo Completed
  13. Phase 3 Management of Etonogestrel Subdermal Implant-related Bleeding Completed
  14. Phase 3 Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis Completed
  15. Phase 3 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed
  16. Phase 3 Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome Completed
  17. Phase 3 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed
  18. Phase 2 Oral Azithromycin Versus Doxycycline in Posterior Blepharitis Completed
  19. Phase 2 The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID) Completed
  20. Phase 2 Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial Completed
  21. Phase 2 Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers Completed
  22. Phase 2 Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab Completed
  23. Phase 2 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers Completed
  24. Phase 2 Doxycycline to Upgrade Organ Response in Light Chain (AL) Amyloidosis Trial Completed
  25. Phase 2 Efficacy of Doxycycline on Metakaryote Cell Death in Patients With Resectable Pancreatic Cancer Completed
  26. Phase 2 Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO Completed
  27. Phase 2 Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP) Completed
  28. Phase 2 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed
  29. N/A Doxycycline for COPD in HIV-Infected Patients Completed
  30. N/A A Study of Continuous Oral Contraceptives and Doxycycline Completed
  31. N/A Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty? Completed
  32. N/A Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial Matrix Metalloproteinases Completed
  33. N/A A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions Completed
  34. N/A Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients Completed
  35. N/A Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA) Completed
  36. N/A Duration of Antibiotic Treatment of Erythema Migrans Completed

Showing the 42 most-cited and recently-updated of 42 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Moxifloxacin achieves 87.0% microbiological cure in Mycoplasma genitalium compared to 61.2% for azithromycin
Infectious Disease RCT
Moxifloxacin achieves 87.0% microbiological cure in Mycoplasma genitalium compared to 61.2% for azithromycin Trial shows moxifloxacin more effective than azithromycin for MG
This randomized trial of 358 adults with Mycoplasma genitalium infection found moxifloxacin 400 mg daily for 10 days superior to azithromyci…
A new trial shows moxifloxacin has a higher success rate than azithromycin for treating Mycoplasma genitalium infections in adults.
Sep 11, 2026
Doxycycline significantly reduces Wolbachia burden in patients with bancroftian filariasis
Infectious Disease Meta-analysis
Doxycycline significantly reduces Wolbachia burden in patients with bancroftian filariasis Doxycycline Reduces Wolbachia Burden in Lymphatic Filariasis Patients
This meta-analysis evaluates the impact of doxycycline on Wolbachia burden and microfilarial counts in patients with bancroftian filariasis.…
Doxycycline may reduce Wolbachia levels in patients with lymphatic filariasis, though its impact on lymphedema remains limited.
Sep 4, 2026
Doxycycline is the best supported alternative to benzathine penicillin for treating infectious syphilis
Infectious Disease Sys. Review
Doxycycline is the best supported alternative to benzathine penicillin for treating infectious syphilis Doxycycline shows promise as syphilis treatment alternative
This systematic review and network meta-analysis of 1623 participants evaluates alternative treatments for infectious syphilis. The analysis…
A new review suggests doxycycline may cure syphilis when penicillin isn't an option, but the evidence is weak.
Sep 3, 2026
Antibiotic residues found in 42.6% of chicken products across Africa, meta-analysis reports
Infectious Disease Meta-analysis
Antibiotic residues found in 42.6% of chicken products across Africa, meta-analysis reports Antibiotic Residues Found in African Chicken Products and Eggs
This meta-analysis of 52 sample-specific datasets from 39 articles estimates that 42.60% of chicken products in Africa contain antibiotic re…
A review of 52 datasets shows that over 40% of chicken products in Africa contain traces of antibiotics like doxycycline and oxytetracycline…
Sep 3, 2026
Doxycycline postexposure prophylaxis associated with increased antimicrobial resistance markers in Neisseria gonorrhoeae infections
Infectious Disease RCT
Doxycycline postexposure prophylaxis associated with increased antimicrobial resistance markers in Neisseria gonorrhoeae infections Doxycycline Use Linked to Increased Antibiotic Resistance in Gonorrhea
This trial substudy investigated the impact of DoxyPEP on antimicrobial resistance in men who have sex with men on HIV preexposure prophylax…
A clinical trial sub-study found that using doxycycline as a post-exposure treatment may lead to higher rates of antibiotic resistance in go…
Aug 14, 2026
Protocol for comparing azithromycin and doxycycline with beta-lactams in community-acquired pneumonia
Infectious Disease RCT
Protocol for comparing azithromycin and doxycycline with beta-lactams in community-acquired pneumonia New trial to test azithromycin vs doxycycline for pneumonia
This is a protocol for a planned randomized clinical trial involving 1120 adult patients hospitalized with community-acquired pneumonia. No …
A large trial will compare two antibiotic combos for hospitalized pneumonia patients. Which works better?
Jul 28, 2026
Metagenomic sequencing identifies Rickettsia felis encephalitis in a child who fully recovered
Pediatrics Sys. Review
Metagenomic sequencing identifies Rickettsia felis encephalitis in a child who fully recovered Rare Cat Flea Bacteria Causes Encephalitis in Child
This case report and literature review describes a 9-year-old boy with R. felis encephalitis diagnosed via metagenomic next-generation seque…
A 9-year-old boy's severe brain infection was caused by a rare cat flea bacteria, not a virus. He recovered after targeted treatment.
Frontiers Jul 28, 2026
Vonoprazan-amoxicillin dual therapy is a safe alternative to bismuth-containing quadruple therapy for H. pylori
Infectious Disease RCT
Vonoprazan-amoxicillin dual therapy is a safe alternative to bismuth-containing quadruple therapy for H. pylori New vonoprazan treatments show promise for clearing H. pylori infection
This multicenter randomized controlled trial of 579 H. pylori-positive patients found that vonoprazan-amoxicillin (VA) dual therapy demonstr…
Two new simplified drug combinations could offer a simpler way to clear H. pylori infections, especially for patients with certain allergies…
Frontiers Jul 5, 2026
Doxycycline provides higher odds of microbiological cure compared to azithromycin in cis-men with chlamydia
Infectious Disease Meta-analysis
Doxycycline provides higher odds of microbiological cure compared to azithromycin in cis-men with chlamydia Doxycycline Shows Higher Cure Rates for Chlamydia in Men
This systematic review and meta-analysis of 1172 patients found that doxycycline (OR = 2.525, 95% CI: 1.329-4.796, p = 0.005) provides a hig…
A review of clinical data suggests doxycycline may be more effective than azithromycin for treating chlamydia infections in men.
Jul 3, 2026
Case report on Brucella periprosthetic joint infection after knee replacement
Orthopedics & Sports Medicine Sys. Review
Case report on Brucella periprosthetic joint infection after knee replacement Two rare knee infections treated with specific antibiotics and surgery
This is a case report of two patients with Brucella-induced periprosthetic joint infection after total knee arthroplasty. The authors descri…
Two patients with rare Brucella knee infections saw normal markers and restored motion after targeted antibiotic therapy and surgery.
Frontiers May 22, 2026
Systematic review and meta-analysis compares oral azithromycin and doxycycline for moderate to severe acne
Infectious Disease Meta-analysis
Systematic review and meta-analysis compares oral azithromycin and doxycycline for moderate to severe acne Azithromycin may work better than doxycycline for some acne cases
This systematic review and meta-analysis synthesized evidence on oral azithromycin pulse therapy versus doxycycline for moderate to severe a…
A new review finds azithromycin pulse therapy may improve acne more than doxycycline, with fewer side effects for some patients.
May 5, 2026
Narrative review suggests phytochemicals and phages may augment conventional antibiotics for brucellosis
Oncology Sys. Review
Narrative review suggests phytochemicals and phages may augment conventional antibiotics for brucellosis New plant-based and phage options might help treat stubborn brucellosis infections in people and animals
This narrative review discusses novel strategies for treating brucellosis in humans and animals. The authors note that conventional antibiot…
Standard antibiotics sometimes fail to cure brucellosis, and bacteria are becoming resistant. New methods using plant chemicals and viruses …
Frontiers May 2, 2026

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