Intraosseous vancomycin reduces primary TKA infection risk and improves local tissue concentrations
Injecting antibiotics into bone may lower joint infection risk
This meta-analysis of 13 studies involving 6876 cases found that intraosseous (IO) vancomycin significantly increased bone and fat tissue co…
Delivering vancomycin directly into the bone during hip or knee surgery can significantly lower infection rates and wound complications.
Multimodal laboratory diagnostics improve detection of biofilm-encased pathogens and polymicrobial infections in bone and joint infections
New Laboratory Tools Improve Diagnosis of Bone and Joint Infections
This narrative review synthesizes current evidence regarding laboratory diagnostics for bone and joint infections, including serum markers, …
Advanced molecular tests and tissue processing are improving how doctors identify complex bone and joint infections that traditional culture…
Case report on Brucella periprosthetic joint infection after knee replacement
Two rare knee infections treated with specific antibiotics and surgery
This is a case report of two patients with Brucella-induced periprosthetic joint infection after total knee arthroplasty. The authors descri…
Two patients with rare Brucella knee infections saw normal markers and restored motion after targeted antibiotic therapy and surgery.
Dental antibiotic prophylaxis does not reduce periprosthetic joint infection risk in total joint arthroplasty patients
Routine dental antibiotics do not lower infection risk for joint replacement patients
This systematic review and meta-analysis evaluated 157466 adult patients who had total joint arthroplasty undergoing dental procedures.
A massive review of over 157,000 patients found that taking antibiotics before dental work does not reduce infection risk for those with joi…
One-stage revision shows comparable infection control to two-stage revision in chronic periprosthetic joint infection
One Surgery Could Fix Your Joint Infection
This retrospective cohort study evaluated chronic periprosthetic joint infection (PJI) patients undergoing one-stage versus two-stage revisi…
One surgery for joint infections works as well as the standard two-stage process, letting patients recover faster without the long wait.
Questions about periprosthetic joint infection
Can Brucella bacteria cause a periprosthetic joint infection after knee replacement?
Yes, Brucella bacteria can cause a periprosthetic joint infection after knee replacement, though it is rare and often hard to diagnose.
Full answer →Can laboratory diagnostics better detect pathogens in a periprosthetic joint infection?
Yes, newer lab methods like synovial fluid biomarkers, sonication, and molecular tests (PCR, ddPCR) detect PJI pathogens better than standard cultures, improving treatment and cure rates.
Full answer →Is one-stage revision as effective as two-stage for periprosthetic joint infection?
Evidence suggests one-stage revision can be as effective as two-stage for periprosthetic joint infection, with comparable infection control and reinfection rates in several studies.
Full answer →Can dental antibiotic prophylaxis prevent a periprosthetic joint infection after surgery?
Current evidence shows dental antibiotic prophylaxis does not significantly reduce periprosthetic joint infection risk after joint replacement.
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