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Single-stage reconstruction shows no significant difference compared to staged reconstruction for bowel continenceSingle and staged surgery show similar results for bowel control

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Key Takeaway
Note that current evidence shows no significant difference in bowel continence between single-stage and staged reconstruction.

This meta-analysis evaluated outcomes for neonates with high or intermediate anorectal malformations undergoing either single-stage or staged reconstruction. The analysis focused on bowel continence as the primary outcome and infection outcomes as secondary measures.

The synthesis of data from 746 patients showed no significant difference in bowel continence between the two surgical approaches (RR 0.93; 95% CI: 0.52-1.66, p=0.80). The authors noted that a wide prediction interval (0.28-3.08) indicates substantial uncertainty regarding the results. Infection data could not be pooled due to methodological concerns in outcome reporting.

The study notes several limitations, including substantial heterogeneity (I2=83%) for incontinence outcomes and a moderate to serious risk of bias in all included studies. GRADE certainty was LOW for incontinence and VERY LOW for infection. Current evidence does not demonstrate superiority of either approach for bowel continence, and the data are insufficient to synthesize findings regarding infection rates.

How this fits prior evidence

This meta-analysis addresses the clinical choice between single-stage and staged reconstruction for anorectal malformations. While this study finds no significant difference in bowel continence (RR 0.93; 95% CI: 0.52-1.66), it does not address the previously reported higher wound dehiscence risk with single-stage repair for anorectal malformations in neonates and infants.

When a baby is born with an anorectal malformation, doctors must decide how to repair the digestive tract. The big question is whether doing it all at once (single-stage) or breaking it into multiple steps (staged) leads to better long-term results for bowel control.

A review of data from 746 infants found no significant difference in bowel continence between the two methods. While both approaches are common, the evidence suggests that one method does not clearly outperform the other when it comes to the child's ability to control their bowels later on.

However, there is a lot of uncertainty in these results. The data used for this review was inconsistent across different studies, and the information regarding infection rates was too limited to compare the two methods accurately. Because of these gaps, doctors still have many factors to consider when choosing the best path for each specific child.

What this means for you:
Both single-stage and staged surgeries show similar results for bowel control in infants with certain conditions.

Common questions

Is one surgical method better for bowel control?

The data from 746 infants showed no significant difference in bowel continence between single-stage and staged reconstructions. Because the results were similar, current evidence does not show that one specific approach is superior to the other for helping a child control their bowels.

Are there known risks or infections with these procedures?

The study was unable to provide a clear comparison of infection outcomes because the data across different studies were not consistent enough to combine. Because of this, the evidence for infection risk is currently insufficient to determine if one method is safer than the other.

How certain are these results?

The certainty of the findings regarding bowel control was low due to high variation in the studies. Additionally, there was a lot of uncertainty in the data, meaning that while no difference was found, the evidence is not yet strong enough to rule out differences.

Study Details

Study typeMeta analysis
Sample sizen = 746
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
The surgical approach to high and intermediate anorectal malformations remains controversial. This systematic review compared continence and infection outcomes between the two approaches. MEDLINE, Embase, and Cochrane CENTRAL were searched per a registered protocol (PROSPERO CRD420261291319). Comparative studies of single-stage versus staged repair in neonates with high or intermediate anorectal malformations were included. Risk of bias was assessed using ROBINS-I. Random-effects meta-analysis with prediction intervals was performed. Four comparative studies (746 patients: 399 single-stage, 347 staged) were included. Pooled analysis showed no significant difference in incontinence outcomes (RR 0.93, 95% CI: 0.52-1.66, p = 0.80; 95% prediction interval: 0.28-3.08) with substantial heterogeneity (I²=83%). Infection data could not be pooled due to methodological concerns in outcome reporting. All included studies demonstrated moderate to serious risk of bias. GRADE certainty was LOW for incontinence and VERY LOW for infection. Current evidence does not demonstrate superiority of either approach for bowel continence (LOW certainty). Infection evidence was insufficient for synthesis (VERY LOW). Wide prediction intervals indicate substantial uncertainty; available data cannot confirm or refute inferior outcomes after single-stage repair. Prospective studies with standardized outcomes are needed. Protocol registration: PROSPERO CRD420261291319.
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