Living with systemic lupus erythematosus (SLE) as a child is challenging, but certain signs can indicate a higher risk of serious complications. New data shows that children with high disease activity are significantly more likely to experience multisystem issues. These include problems affecting the kidneys, the brain, and the eyes.
Researchers looked at data from nearly 5,000 children with lupus. They found that those with high disease activity had a much higher chance of developing lupus nephritis, which is inflammation of the kidneys. They also found a much higher risk of neuropsychiatric involvement, which involves the brain and nervous system, and immunological abnormalities.
While the data shows a strong link between high activity and organ damage, the study notes that the results varied across different reports. These findings help doctors use activity scores to better identify which children might need closer monitoring for organ involvement.
