Dapirolizumab pegol increases BICLA response rate by 14.6% over placebo in moderate-to-severe SLE
Trial shows dapirolizumab pegol improves symptoms for lupus patients
This Phase 3 randomized controlled trial of 321 patients with moderate-to-severe, active SLE found that dapirolizumab pegol added to standar…
A new clinical trial found that dapirolizumab pegol significantly improved disease activity for adults with moderate to severe systemic lupu…
SLE patients have a 2- to 3-fold higher risk of intracerebral hemorrhage compared to non-SLE populations
Lupus Patients Face Higher Risk of Brain Bleeding
This literature review and case report analyze the association between systemic lupus erythematosus (SLE) and intracranial hemorrhage (ICH).…
Patients with systemic lupus erythematosus may face a much higher risk of brain bleeds compared to those without the condition.
Systemic immune-inflammation index and systemic inflammation response index correlate with disease activity in systemic lupus erythematosus
Inflammation markers are higher in lupus patients than in healthy people
This meta-analysis of eleven studies involving individuals with systemic lupus erythematosus and healthy controls examined inflammatory mark…
A new analysis shows inflammation markers are much higher in people with lupus. These markers also track closely with how active the disease…
Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
Stress hormones may harm bone growth in children with inflammatory conditions
This narrative review synthesizes evidence from animal models and pediatric inflammatory disorders showing that stress-induced IL-6 upregula…
A review suggests stress-induced IL-6 upregulation impairs skeletal growth and bone health in kids with inflammatory disorders, highlighting…
Adrenal insufficiency is first manifestation in 73.6% of APS patients with adrenal involvement
Review finds adrenal crisis common in lupus and antiphospholipid syndrome cases
This systematic review and pooled individual-patient analysis of 155 published APS/SLE-spectrum patients with adrenal involvement found that…
A review of 155 patients shows adrenal crisis is frequent in lupus and antiphospholipid syndrome, highlighting the need for urgent care.
STAT3 inhibition targets cytokine signaling and renal inflammation in systemic lupus erythematosus and lupus nephritis
New review suggests STAT3 inhibition could help lupus kidney disease
This narrative review examines the role of STAT3 in systemic lupus erythematosus and lupus nephritis. The authors argue that STAT3 integrate…
A narrative review suggests targeting STAT3 might treat lupus kidney inflammation, though direct drug targeting remains unproven in patients…
SLE linked to 53% higher odds of cognitive impairment in meta-analysis of 7 million
Lupus linked to higher risk of cognitive decline
This meta-analysis of 7 observational studies involving over 7 million participants found that systemic lupus erythematosus (SLE) is signifi…
People with lupus may face 53% higher odds of cognitive impairment, a large analysis finds.
Epstein–Barr virus infection shows higher seropositivity and viral loads in systemic lupus erythematosus patients compared to healthy controls
Epstein-Barr virus linked to lupus in new review of patient data
A mini review highlights that Epstein–Barr virus infection is more prevalent and active in patients with systemic lupus erythematosus than i…
A new review finds that Epstein-Barr virus is more common and active in lupus patients, suggesting a role in the disease.
Subcutaneous anifrolumab improves BICLA response by 15.5% in moderate to severe SLE
Anifrolumab injection improves lupus outcomes in trial
This phase 3 RCT in 367 adults with moderate to severe SLE found that subcutaneous anifrolumab 120 mg weekly plus standard therapy improved …
A weekly injection of anifrolumab helped more people with lupus achieve disease control than placebo, a phase 3 trial shows.
Tubulointerstitial inflammation and fibrosis predict renal function decline in adult lupus nephritis patients across multiple studies
Kidney damage in lupus is linked to specific tissue changes seen in scans
A systematic review of 3,607 adult patients reveals that tubulointerstitial inflammation and fibrosis significantly increase the risk of ren…
A large review found that kidney tissue changes called tubulointerstitial inflammation and fibrosis raise the risk of kidney failure in lupu…
Core set domains capture SLE treatment response in 89.5% of cases at week 52
Core set domains capture most lupus disease activity in a global trial
This phase III randomized controlled trial evaluated subjects with Systemic Lupus Erythematosus across a global setting. The study compared …
A global trial found that a core set of domains captured most lupus disease activity without missing important patient responses.
Meta-analysis finds hydroxychloroquine does not reduce most pregnancy complications in SLE
Hydroxychloroquine May Lower Risk of Fetal Growth Restriction in Lupus Pregnancy
This meta-analysis of observational studies and RCTs assessed hydroxychloroquine use in pregnant women with SLE. It found no significant red…
In lupus pregnancies, hydroxychloroquine was linked to lower risks of fetal growth restriction and gestational diabetes, but not other compl…
Questions about Systemic Lupus Erythematosus
How do biologics compare to targeted drugs for treating systemic lupus erythematosus?
Biologics (e.g., anifrolumab, belimumab) and targeted drugs (e.g., telitacicept, upadacitinib) both treat SLE, but network meta-analyses show telitacicept may outperform belimumab for SRI-4 response, while anifrolumab and deucravacitinib work better for skin symptoms. Safety prof
Full answer →How common is female sexual dysfunction in women with systemic lupus erythematosus according to recent studies?
Recent studies show that about 59% of women with systemic lupus erythematosus experience sexual dysfunction, which is significantly higher than in healthy women.
Full answer →All Systemic Lupus Erythematosus Articles
- SLE patients have a 2- to 3-fold higher risk of intracerebral hemorrhage compared to non-SLE populations
- Dapirolizumab pegol increases BICLA response rate by 14.6% over placebo in moderate-to-severe SLE
- Systemic immune-inflammation index and systemic inflammation response index correlate with disease activity in systemic lupus erythematosus
- Adrenal insufficiency is first manifestation in 73.6% of APS patients with adrenal involvement
- Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
- STAT3 inhibition targets cytokine signaling and renal inflammation in systemic lupus erythematosus and lupus nephritis
- SLE linked to 53% higher odds of cognitive impairment in meta-analysis of 7 million
- Epstein–Barr virus infection shows higher seropositivity and viral loads in systemic lupus erythematosus patients compared to healthy controls
- Subcutaneous anifrolumab improves BICLA response by 15.5% in moderate to severe SLE
- Tubulointerstitial inflammation and fibrosis predict renal function decline in adult lupus nephritis patients across multiple studies
- Meta-analysis finds hydroxychloroquine does not reduce most pregnancy complications in SLE
- Core set domains capture SLE treatment response in 89.5% of cases at week 52
- Meta-analysis finds systemic lupus erythematosus elevates coronary artery disease risk
- Narrative review discusses CD40/CD40L signaling regulation in rheumatoid arthritis and other autoimmune conditions
- Commentary on plateau in lupus nephritis trials and path to precision medicine
- Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
- Enpatoran fails to show dose-response in moderate-to-severe SLE phase 2 trial
- Review of SC-EVs for SLE and MS highlights immunomodulatory mechanisms and neuroprotective potential
- Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
- SLE-DAS Responder Index shows 34% response rate in systemic lupus erythematosus trials
- Narrative review highlights limited data on connective tissue disease-associated PAH in Han Chinese populations
- Meta-analysis shows increased risk of female sexual dysfunction in women with systemic lupus erythematosus
- Psychosis Prevalence in SLE Patients: Meta-Analysis of 31,495 Adults
- Network meta-analysis compares biologics and targeted drugs for systemic lupus erythematosus efficacy and safety
- Systematic review explores the role of RNA methylation in autoimmune rheumatic diseases
- Narrative review of transposable element methylation in autoimmune diseases
- Umbrella review identifies risk factors and protective factors for male infertility and semen quality
- Individualized intervention plans improved stress management and pain management in African American lupus patients compared to usual care
- Meta-analysis of belimumab versus anifrolumab in systemic lupus erythematosus and lupus nephritis
- Meta-analysis links CYP2C19*2 polymorphism to reduced cyclophosphamide toxicity in SLE
- Vitamin D supplementation may reduce disease activity in SLE: a systematic review and meta-analysis
- Systematic Review Links Lysosomal Pathways to Autoimmune Kidney Disease Progression
- Mini Review Covers Complement Pathways in Kidney Diseases and Injuries
- Telitacicept plus standard therapy in SLE patients with antiphospholipid antibodies
- Narrative review explores TLR7 and TLR9 signaling networks within systemic lupus erythematosus and Sjögren's disease contexts
- Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations
- Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
- Systematic review of immunosuppression for SLE-associated intestinal pseudo-obstruction
- Rituximab pharmacokinetics vary widely in membranous nephropathy, minimal change disease, and lupus nephritis patients
- Obesity associated with reduced SLE relapse rates in Japanese registry cohort
- Case-Control Study Finds No Association Between G6PD Deficiency and Systemic Lupus Erythematosus Risk in Females
- Retrospective Analysis of Repeat Kidney Biopsy Outcomes in 19 Pediatric Lupus Nephritis Patients
- Narrative review explores emerging therapeutic strategies targeting Th17 and Treg balance in systemic lupus erythematosus
- Case report details KFD patient developing SLE treated with immunosuppression
- Meta-analysis links long-term glucocorticoid use and SLE duration to high osteoporosis prevalence in patients
- JSLE linked to higher CVD risk factors than JDM in adults with childhood-onset autoimmune diseases
- Therapeutic plasma exchange in pediatric autoimmune diffuse alveolar hemorrhage shows 5 of 6 survival
- Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
- Anifrolumab shows higher remission rates versus placebo in SLE patients regardless of immunosuppressant history
- Hydroxychloroquine did not prevent SLE progression in incomplete lupus patients in randomized trial
- IFN-I signature correlates with alloimmunization transcriptomic programs in SLE patients
- Peer mentoring shows non-significant symptom reduction in African American women with SLE
- LOC100130476 rs80213143 variant associated with SLE susceptibility and renal involvement in Chinese Han cohort
- Meta-analysis finds elevated neutrophil-to-lymphocyte ratio in SLE, with weak correlation to disease activity
- Review examines glucose metabolic reprogramming in SLE and lupus nephritis pathogenesis
- Perspective highlights diagnostic overlap between idiopathic multicentric Castleman disease and systemic lupus erythematosus
- Phase 3 Trial: Anifrolumab Shows Promise in SLE with BICLA Response as Primary Outcome
- Phase 3 Trial of Cenerimod for Lupus Nephritis: Efficacy and Safety Evaluation