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Early adenotonsillectomy improves clinical outcomes in 65% of children with mild sleep-disordered breathingEarly surgery improves quality of life for children with breathing issues

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Key Takeaway
Consider early adenotonsillectomy for children with MSDB, noting that a high Mallampati score may predict better outcomes.

This randomized clinical trial analyzed 363 children aged 3.0 to 12.9 years with mild sleep-disordered breathing (MSDB). The study compared early adenotonsillectomy (eAT) against watchful waiting with supportive care (WWSC) over a 12-month follow-up period.

The primary outcome was clinically-meaningful improvement in at least 2 of 4 domains: behavior, quality of life, subjective sleepiness, and blood pressure. Results showed that 115 (65%) of children in the eAT group achieved these improvements, compared to 73 (39%) in the WWSC group (p <.01). A high Mallampati score was identified as a predictor for success, with an OR of 4.16 (95% CI 1.22, 15.6).

Safety data, including adverse events and discontinuations, were not reported. A noted limitation is that only a high Mallampati score showed predictive value among the variables explored for effect modification. Clinically, eAT leads to meaningful improvements at 12 months for children with MSDB, and the Mallampati score may help identify specific children likely to benefit.

How this fits prior evidence

How this fits prior evidence: This finding extends the clinical management of pediatric sleep-disordered breathing by providing a clear outcome for early adenotonsillectomy. While previous coverage noted that adding turbinate ablation to adenotonsillectomy shows no added benefit for pediatric SDB, this study confirms the efficacy of the adenotonsillectomy procedure alone. Additionally, while previous coverage identified asthma, ADHD, and higher baseline symptoms as predictors for progression in children with mild sleep-disordered breathing, this study identifies the Mallampati score as a specific predictor for clinical improvement following surgery.

Living with sleep-disordered breathing can be exhausting for children, often leading to issues with behavior and overall quality of life. A recent study looked at how early surgery, known as an adenotonsillectomy, compares to watchful waiting and supportive care for children aged 3 to 12 with mild symptoms.

The study followed 363 children over 12 months. The results showed that 65% of children who had the surgery saw meaningful improvements in at least two key areas, such as behavior or quality of life. In contrast, only 39% of children who received watchful waiting saw those same improvements.

While the surgery showed clear benefits, the researchers noted that not every child responds the same way. They found that a specific physical marker called a high Mallampati score helped predict which children would see the most benefit from the procedure. This helps doctors identify which children might need surgery sooner.

What this means for you:
Early surgery for mild sleep-disordered breathing can improve behavior and quality of life for many children.

Common questions

What are the benefits of early surgery for children with breathing issues?

Children who had early surgery showed a much higher rate of improvement. About 65% of children who had the surgery saw meaningful improvements in areas like behavior, quality of life, sleepiness, or blood pressure. In comparison, only 39% of children who were managed with watchful waiting and supportive care saw these improvements.

How does the study measure success for these children?

The study looked at four main areas: behavior, quality of life, how sleepy the child felt, and blood pressure. A child was considered to have a meaningful improvement if they showed better results in at least two of these four categories after 12 months.

Can doctors tell which children will benefit most from surgery?

The study found that a high Mallampati score, which is a physical measurement, could help predict which children would benefit from surgery. While the surgery was effective for many, this specific score helped identify children who were more likely to see a significant improvement.

Study Details

Study typeRct
Sample sizen = 363
EvidenceLevel 2
Follow-up12.0 mo
PublishedOct 2026
View Original Abstract ↓
STUDY OBJECTIVES: To examine clinically meaningful benefit that may be achieved by early adenotonsillectomy (eAT) vs. watchful waiting with supportive care (WWSC) in children with mild sleep-disordered breathing (MSDB, snoring but little or no obstructive sleep apnea), and to identify baseline demographic, symptom, physical exam, historical, or polysomnographic features that may predict such benefit. MATERIALS AND METHODS: Secondary analysis of participants (aged 3.0-12.9 years) in the 12-month multi-center randomized clinical trial of eAT vs. WWSC for MSDB, the Pediatric Adenotonsillectomy Trial for Snoring (PATS). Meaningful benefit was defined as a composite outcome of clinically-significant change in at least two of four domains-behavior, quality of life, subjective sleepiness, and blood pressure-each of which had shown greater improvement 12 months after AT versus WWSC in PATS. RESULTS: Among 363 participants, the mean age was 6.6 (SD 2.3) years, 199 (55%) were >5 years old at enrollment, and 185 (51%) were male. A total of 115 (65%) vs. 73 (39%) in the eAT vs. WWSC arms, respectively, experienced clinically-meaningful improvement on ≥2 domains (p < .01). Among variables explored for effect modification-including demographics, health factors, symptoms and signs, and polysomnographic data-only a high Mallampati score of III or IV vs. I or II showed predictive value (OR 4.16, 95% CI [1.22, 15.6], p = .027). CONCLUSIONS: Clinically meaningful positive outcomes occur more often after eAT vs. WWSC for children with MSDB. However, many clinical features accessible prior to AT, with the intriguing exception of a high Mallampati score, may not help to identify which children stand to benefit. CLINICAL TRIAL: Pediatric Adenotonsillectomy for Snoring (PATS); https://clinicaltrials.gov/study/NCT02562040; Registration number: NCT02562040. Statement of Significance This study provides important insights into the management of mild sleep-disordered breathing (MSDB) in children. Results demonstrate that adenotonsillectomy (AT) leads to clinically meaningful improvements at 12 months reassessment, in that a greater proportion of children treated with AT as opposed to WWSC benefitted in at least two of four domains, including behavior, quality of life, sleepiness, and blood pressure. Most routinely available clinical features and findings before surgery did not predict which children would benefit most from AT, though a high Mallampati score may serve as a useful indicator. These data may help clinicians and families to understand the potential benefit of AT and decide on treatment strategies for pediatric MSDB.
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