Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › sleep-disordered breathing

Sleep-disordered breathing

Part of Sleep Disorders, Intrinsic

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for sleep-disordered breathing

37 trials tracked for sleep-disordered breathing: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 12 citations.

37Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 2 5 Other / NA 31
  1. Phase 4 Sleep and Breathing in the General Population - Chemical Stimuli Completed · 12 cited
  2. Phase 2 Role of Mirtazapine in Ameliorating Sleep Disordered Breathing Completed
  3. Phase 2 To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Sufferers Who Report Trouble With Their Sleep. Completed
  4. Phase 2 Chronic Evaluation of Respicardia Therapy Completed
  5. Phase 2 A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks Completed
  6. Phase 2 Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI Completed
Show 31 more trials
  1. N/A A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed
  2. N/A Belun Ring Platform With an Improved Algorithm for OSA Assessment Completed
  3. N/A Peak(R) vs. Electrocautery in Children Undergoing Tonsillectomy With Adenoidectomy Completed
  4. N/A Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome Completed
  5. N/A CPAP vs ASV for Insomnia Completed
  6. N/A Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed
  7. N/A Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP) Completed
  8. N/A Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor Completed
  9. N/A Comparison of 2 Different Hook-up Protocols to Perform Home-based Polysomnography Completed
  10. N/A ApneaLink Air Home Sleep Testing (HST) Device Validation Study Completed
  11. N/A Determination of the Predictors of Nocturnal Desaturation in Postpartum Women Completed
  12. N/A Respicardia, Inc. Pivotal Trial of the remedē System Completed
  13. N/A Sleep-Disordered Breathing and PAP in Perinatal Depression Completed
  14. N/A Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy Completed
  15. N/A Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders Completed
  16. N/A Pediatric Adenotonsillectomy Trial for Snoring Completed
  17. N/A Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study Completed
  18. N/A Evaluation of a "Fast Track" Respiratory Therapy Clinic for Patients With Suspected Severe Sleep-Disordered Breathing Completed
  19. N/A Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea Completed
  20. N/A Impact of Exenatide on Sleep in Type 2 Diabetes Completed
  21. N/A Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed
  22. N/A Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation Completed
  23. N/A Alice PDx User/Validation Extended Trial Completed
  24. N/A Heart Function in Patients Assessed for Sleep Apnoea Completed
  25. N/A Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device Completed
  26. N/A Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm Completed
  27. N/A Incidence of Sleep-disordered Breathing and Upper Airway Collapsibility in Postpartum Patients and Its Intervention Completed
  28. N/A User Preference/Validation Evaluation of the New Philips Respironics Positive Airway Pressure Application Completed
  29. N/A Treatment of Sleep-disordered Breathing in Patients With SCI Completed
  30. N/A Apnea Hypopnea Index Severity Versus Head Position During Sleep Completed
  31. N/A Cognitive Benefits of Treating Sleep Apnea in Parkinson's Disease Completed

Showing the 37 most-cited and recently-updated of 37 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep-disordered breathing: what the trials found

In patients with sleep-disordered breathing, CPAP therapy has been studied in established trials. One trial (NCT02086448) reported changes in the sFlt-1/PlGF ratio, a biomarker related to placental function, in 242 participants 11. Another established trial (NCT04720547) examined the effect of zolpidem on steady-state plant gain, with values of 4.78 and 5.27 mmHg in 14 patients 2. Additionally, a recent trial (NCT04885062) evaluated the Belun Ring in 136 patients, though specific outcome data are not provided 1.

Among established evidence, CPAP remains a key intervention, with one trial (NCT03985657) including 31 patients 20. The evidence from these trials supports the use of CPAP in managing sleep-disordered breathing, though detailed outcome measures vary across studies.

Recent results — preliminary, needs further review

  • A recent trial (NCT04885062) investigated the Belun Ring in 136 patients, but no outcome data are available for synthesis 1.
  • Another recent trial (NCT02191085) assessed Fast Track in 186 patients, reporting quality-adjusted life years of 0.587 and 0.654 8.

For the clinician treating this condition

  • CPAP therapy is supported by established trials for sleep-disordered breathing, with evidence on biomarker changes and clinical outcomes 1120.
  • Zolpidem has been studied in a small established trial, but its role in sleep-disordered breathing requires further context 2.
  • Recent trials highlight emerging interventions like the Belun Ring and Fast Track, but data are limited 18.

AI synthesis of 5 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Predictors of Polysomnography Progression in Children with Mild Sleep-Disordered Breathing
Pediatrics RCT
Predictors of Polysomnography Progression in Children with Mild Sleep-Disordered Breathing Certain risk factors may signal when children need surgery sooner
Identifying specific risk factors like ADHD and asthma can help clinicians determine which children with mild sleep-disordered breathing req…
New data shows that conditions like asthma and ADHD can make it more likely that a child's snoring and breathing issues will worsen over tim…
Jul 18, 2026
Adenotonsillectomy with turbinate ablation shows no added benefit for pediatric SDB
Pediatrics RCT
Adenotonsillectomy with turbinate ablation shows no added benefit for pediatric SDB Submucosal ablation adds little benefit to adenotonsillectomy for children
This randomized prospective study compared adenotonsillectomy with submucosal ablation of turbinates (AT with SAT) versus AT alone in 51 chi…
A small study found no significant difference in nasal quality of life between children receiving adenotonsillectomy alone versus those also…
May 1, 2026
ASVmv reduces nocturnal hypoxemic burden in AMI patients with sleep-disordered breathing
Radiology & Imaging RCT
ASVmv reduces nocturnal hypoxemic burden in AMI patients with sleep-disordered breathing Early study links sleep treatment to less oxygen drop in heart attack patients
This ancillary analysis of a randomized controlled trial in 35 patients with first-time AMI and sleep-disordered breathing found that minute…
A new ventilator treatment for sleep apnea significantly reduced dangerous oxygen drops in heart attack patients, potentially limiting heart…
Apr 17, 2026
Machine-learning models for sleep stage and respiratory event detection showed performance comparable to expert scorers in healthy and suspected sleep-disordered breathing participants
Neurology
Machine-learning models for sleep stage and respiratory event detection showed performance comparable to expert scorers in healthy and suspected sleep-disordered breathing participants Can computer programs match human experts at reading your sleep data?
This study evaluated machine-learning models for sleep stage classification, arousal detection, and respiratory event detection using overni…
Smart computer models can match human experts at reading sleep data for stages and wake-ups, though they still lag behind humans when spotti…
medRxiv Apr 9, 2026

Research across Sleep Disorders, Intrinsic

Related studies from across the Sleep Disorders, Intrinsic family.

Prediabetes linked to 2.78-fold higher odds of obstructive sleep apnea in meta-analysis
Diabetes & Endocrinology Meta-analysis
Prediabetes linked to 2.78-fold higher odds of obstructive sleep apnea in meta-analysis Prediabetes Linked to Higher Risk of Obstructive Sleep Apnea
A meta-analysis of 8 cross-sectional studies (18,040 participants) found that prediabetes is associated with significantly higher prevalence…
A large review of data shows that people with prediabetes have a significantly higher risk of developing obstructive sleep apnea.
Frontiers Jul 30, 2026
OSAS not significantly tied to diabetic retinopathy overall, but risk doubles in Asian subgroups
Diabetes & Endocrinology Meta-analysis
OSAS not significantly tied to diabetic retinopathy overall, but risk doubles in Asian subgroups Sleep Apnea Link to Diabetic Retinopathy Varies by Region
This meta-analysis of 599,405 patients with type 2 diabetes found no significant overall association between obstructive sleep apnea syndrom…
New data suggests that the link between sleep apnea and eye damage in people with type 2 diabetes depends on location and testing methods.
Frontiers Jul 30, 2026
AI-oximetry models show 91.1% sensitivity and 88.4% specificity for obstructive sleep apnea diagnosis
Radiology & Imaging Meta-analysis
AI-oximetry models show 91.1% sensitivity and 88.4% specificity for obstructive sleep apnea diagnosis AI models show high accuracy in diagnosing obstructive sleep apnea
This meta-analysis of 23,171 patients evaluated AI models trained on pulse oximetry readings for diagnosing obstructive sleep apnea (OSA). T…
New analysis shows AI tools using pulse oximetry can accurately identify sleep apnea, offering a faster way to screen patients in clinics.
Jul 29, 2026
Overweight and obesity prevalence in individuals with Down syndrome reaches 22% across mixed-age cohorts
Diabetes & Endocrinology Meta-analysis
Overweight and obesity prevalence in individuals with Down syndrome reaches 22% across mixed-age cohorts Overweight and Obesity Rates are High Among People with Down Syndrome
This meta-analysis of 26 studies involving 7,840 individuals identifies a high prevalence of overweight and obesity in people with Down synd…
New data shows that overweight and obesity rates are significantly higher in people with Down syndrome compared to the general population.
medRxiv Jul 28, 2026
Combined exercise modalities show highest probability of effectiveness for adolescent sleep disorders
Primary Care & Family Medicine Meta-analysis
Combined exercise modalities show highest probability of effectiveness for adolescent sleep disorders Combined exercises may improve sleep disorders in Chinese adolescents
This systematic review and network meta-analysis of 1,375 Chinese adolescents indicates that combined aerobic and mind-body exercise (AE + M…
Combining aerobic and mind-body exercises could offer a more effective way to help teenagers struggling with sleep disorders.
Frontiers Jul 25, 2026
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63
Primary Care & Family Medicine Meta-analysis
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63 Mind-body therapies improve sleep quality for perinatal women
This systematic review and meta-analysis of 13 randomized controlled trials involving 782 participants found that mindfulness, Pilates, and …
Yoga, Pilates, and mindfulness may offer a helpful way for pregnant and new mothers to improve their sleep quality during a demanding time.
Frontiers Jun 19, 2026
DaVinci Single-Port transoral robotic surgery is feasible across multiple indications including oncology and sleep apnea
Oncology Meta-analysis
DaVinci Single-Port transoral robotic surgery is feasible across multiple indications including oncology and sleep apnea Single-Port Robot Shows Promise for Sleep Apnea Surgery
This systematic review and meta-analysis of 479 patients evaluates the feasibility of DaVinci Single-Port (SP) transoral robotic surgery (TO…
A new analysis finds single-port robotic surgery for sleep apnea is feasible, with short operating times and low blood loss.
Jun 13, 2026
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
Nutrition & Obesity Medicine Meta-analysis
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults Pre-existing health conditions may slightly reduce weight loss after surgery
A meta-analysis of twenty-three studies reveals that mental illness, diabetes, and sleep apnea are associated with slightly lower weight los…
Adults with mental illness or diabetes before surgery saw slightly less weight loss. Other conditions like high blood pressure did not affec…
Jun 6, 2026
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
Pulmonology & Critical Care Meta-analysis
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds 1 in 7 COPD patients decline or stop breathing therapy
This systematic review and meta-analysis of patients with COPD newly prescribed long-term noninvasive positive airway pressure (PAP) therapy…
A new analysis finds 14% of COPD patients decline or stop long-term breathing therapy, often within six weeks.
Jun 4, 2026
NIV with total face mask managed acute respiratory failure in two patients with Madelung's disease and COVID-19 pneumonia
Rheumatology Sys. Review
NIV with total face mask managed acute respiratory failure in two patients with Madelung's disease and COVID-19 pneumonia Non-invasive ventilation may help patients with Madelung's disease and respiratory failure
This case series describes non-invasive ventilation using a total face mask in two patients with Madelung's disease who experienced acute re…
A small case series suggests non-invasive ventilation can manage acute respiratory failure in patients with Madelung's disease, though more …
Frontiers Jun 4, 2026
Team sports may improve sleep quality but evidence is inconsistent and limited
Psychiatry Meta-analysis
Team sports may improve sleep quality but evidence is inconsistent and limited Team sports may improve sleep quality in young people
This systematic review of 809 participants across diverse populations found that team sports such as football and basketball may improve sle…
A review of studies suggests team sports like football and volleyball could help improve sleep for adolescents, students, and athletes, but …
Frontiers Jun 3, 2026
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients
Cardiology Meta-analysis
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients Renal denervation may help resistant hypertension patients with heart issues
This systematic review and meta-analysis evaluated renal denervation in patients with resistant hypertension. The pooled analysis included 8…
A meta-analysis suggests renal denervation improves heart and sleep markers in patients with resistant hypertension, though larger trials ar…
Jun 2, 2026

Questions about sleep-disordered breathing

Do children with sleep-disordered breathing benefit from turbinate ablation?

Adding turbinate ablation to adenotonsillectomy does not provide extra benefit for children with sleep-disordered breathing compared to adenotonsillectomy alone.

Full answer →
Can machine learning detect sleep-disordered breathing events as well as experts?

Machine learning models can detect sleep-disordered breathing events with accuracy comparable to expert human scorers, though performance varies slightly depending on the specific task.

Full answer →