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Sleep-disordered breathing

Part of Sleep Disorders, Intrinsic

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for sleep-disordered breathing

37 trials tracked for sleep-disordered breathing: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 12 citations.

37Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 2 5 Other / NA 31
  1. Phase 4 Sleep and Breathing in the General Population - Chemical Stimuli Completed · 12 cited
  2. Phase 2 Role of Mirtazapine in Ameliorating Sleep Disordered Breathing Completed
  3. Phase 2 To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Sufferers Who Report Trouble With Their Sleep. Completed
  4. Phase 2 Chronic Evaluation of Respicardia Therapy Completed
  5. Phase 2 A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks Completed
  6. Phase 2 Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI Completed
Show 31 more trials
  1. N/A A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed
  2. N/A Belun Ring Platform With an Improved Algorithm for OSA Assessment Completed
  3. N/A Peak(R) vs. Electrocautery in Children Undergoing Tonsillectomy With Adenoidectomy Completed
  4. N/A Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome Completed
  5. N/A CPAP vs ASV for Insomnia Completed
  6. N/A Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed
  7. N/A Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP) Completed
  8. N/A Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor Completed
  9. N/A Comparison of 2 Different Hook-up Protocols to Perform Home-based Polysomnography Completed
  10. N/A ApneaLink Air Home Sleep Testing (HST) Device Validation Study Completed
  11. N/A Determination of the Predictors of Nocturnal Desaturation in Postpartum Women Completed
  12. N/A Respicardia, Inc. Pivotal Trial of the remedē System Completed
  13. N/A Sleep-Disordered Breathing and PAP in Perinatal Depression Completed
  14. N/A Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy Completed
  15. N/A Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders Completed
  16. N/A Pediatric Adenotonsillectomy Trial for Snoring Completed
  17. N/A Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study Completed
  18. N/A Evaluation of a "Fast Track" Respiratory Therapy Clinic for Patients With Suspected Severe Sleep-Disordered Breathing Completed
  19. N/A Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea Completed
  20. N/A Impact of Exenatide on Sleep in Type 2 Diabetes Completed
  21. N/A Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed
  22. N/A Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation Completed
  23. N/A Alice PDx User/Validation Extended Trial Completed
  24. N/A Heart Function in Patients Assessed for Sleep Apnoea Completed
  25. N/A Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device Completed
  26. N/A Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm Completed
  27. N/A Incidence of Sleep-disordered Breathing and Upper Airway Collapsibility in Postpartum Patients and Its Intervention Completed
  28. N/A User Preference/Validation Evaluation of the New Philips Respironics Positive Airway Pressure Application Completed
  29. N/A Treatment of Sleep-disordered Breathing in Patients With SCI Completed
  30. N/A Apnea Hypopnea Index Severity Versus Head Position During Sleep Completed
  31. N/A Cognitive Benefits of Treating Sleep Apnea in Parkinson's Disease Completed

Showing the 37 most-cited and recently-updated of 37 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep-disordered breathing: what the trials found

In patients with sleep-disordered breathing, CPAP therapy has been studied in established trials. One trial (NCT02086448) reported changes in the sFlt-1/PlGF ratio, a biomarker related to placental function, in 242 participants 11. Another established trial (NCT04720547) examined the effect of zolpidem on steady-state plant gain, with values of 4.78 and 5.27 mmHg in 14 patients 2. Additionally, a recent trial (NCT04885062) evaluated the Belun Ring in 136 patients, though specific outcome data are not provided 1.

Among established evidence, CPAP remains a key intervention, with one trial (NCT03985657) including 31 patients 20. The evidence from these trials supports the use of CPAP in managing sleep-disordered breathing, though detailed outcome measures vary across studies.

Recent results — preliminary, needs further review

  • A recent trial (NCT04885062) investigated the Belun Ring in 136 patients, but no outcome data are available for synthesis 1.
  • Another recent trial (NCT02191085) assessed Fast Track in 186 patients, reporting quality-adjusted life years of 0.587 and 0.654 8.

For the clinician treating this condition

  • CPAP therapy is supported by established trials for sleep-disordered breathing, with evidence on biomarker changes and clinical outcomes 1120.
  • Zolpidem has been studied in a small established trial, but its role in sleep-disordered breathing requires further context 2.
  • Recent trials highlight emerging interventions like the Belun Ring and Fast Track, but data are limited 18.

AI synthesis of 5 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Sleep Disorders, Intrinsic

Related studies from across the Sleep Disorders, Intrinsic family.

Intermittent hypoxia may disturb intestinal oxygen homeostasis and impair epithelial barrier function in obstructive sleep apnea
Pulmonology & Critical Care Sys. Review
Intermittent hypoxia may disturb intestinal oxygen homeostasis and impair epithelial barrier function in obstructive sleep apnea Sleep apnea may impact gut health and organ function
This narrative review explores how intermittent hypoxia (IH) impacts the gut microbiome and intestinal homeostasis in obstructive sleep apne…
New research explores how sleep apnea affects the gut and how microbes might play a role in heart and brain health.
Obstructive sleep apnea is associated with significant impairment of glymphatic transport via DTI-ALPS index
Neurology Meta-analysis
Obstructive sleep apnea is associated with significant impairment of glymphatic transport via DTI-ALPS index Sleep Disorders and the Brains Waste Removal System Impact on Health
This meta-analysis examines glymphatic-related metrics in patients with obstructive sleep apnea, sleep deprivation, and narcolepsy type 1. F…
New research shows that obstructive sleep apnea may damage the brain's waste cleaning system, potentially leading to long-term brain health …
GLP-1 receptor agonists reduce apnea-hypopnea index by 9.99 events per hour in obstructive sleep apnea
Diabetes & Endocrinology Meta-analysis
GLP-1 receptor agonists reduce apnea-hypopnea index by 9.99 events per hour in obstructive sleep apnea GLP-1 medications show promise for treating obstructive sleep apnea
This meta-analysis of 1069 adults with moderate-to-severe obstructive sleep apnea found that GLP-1 receptor agonists, including liraglutide …
New data suggests that GLP-1 medications like liraglutide and tirzepatide may help reduce sleep apnea symptoms and lower blood pressure.
One anastomosis gastric bypass provides durable weight loss and metabolic improvements over 15 years
Nutrition & Obesity Medicine Meta-analysis
One anastomosis gastric bypass provides durable weight loss and metabolic improvements over 15 years Gastric Bypass Shows Durable Weight Loss and Health Improvements
This meta-analysis of 1729 patients evaluates the long-term outcomes of one anastomosis gastric bypass (OAGB). The analysis indicates durabl…
Gastric bypass surgery can lead to lasting weight loss and improved conditions like diabetes and high blood pressure over 15 years.
Tonsillectomy with adjunctive pharyngoplasty or pillar suturing shows no significant difference in AHI for pediatric OSA
Pediatrics Meta-analysis
Tonsillectomy with adjunctive pharyngoplasty or pillar suturing shows no significant difference in AHI for pediatric OSA Adding extra surgery steps does not improve results for children's sleep apnea
This meta-analysis evaluated the efficacy of tonsillectomy with adjunctive pharyngoplasty or pillar suturing compared to tonsillectomy alone…
Adding extra surgical steps like pharyngoplasty does not improve outcomes for children with obstructive sleep apnea compared to standard ton…
Children with obstructive sleep apnea exhibit moderate neurocognitive deficits compared to healthy non-snoring controls
Pediatrics Meta-analysis
Children with obstructive sleep apnea exhibit moderate neurocognitive deficits compared to healthy non-snoring controls Sleep apnea in children is linked to lower cognitive scores
This meta-analysis of 436 children with polysomnographically confirmed obstructive sleep apnea found moderate neurocognitive deficits (Hedge…
Children with obstructive sleep apnea show moderate cognitive deficits in areas like memory and intelligence compared to healthy peers.
Obstructive sleep apnea is associated with higher blood T-tau and lower CSF amyloid-beta levels
Neurology Meta-analysis
Obstructive sleep apnea is associated with higher blood T-tau and lower CSF amyloid-beta levels Sleep Apnea Linked to Higher Alzheimer's Biomarkers in Blood
This meta-analysis examined Alzheimer's disease related biomarkers in patients with obstructive sleep apnea (OSA) compared to non-OSA contro…
New research shows that people with obstructive sleep apnea have higher levels of certain Alzheimer's markers in their blood and spinal flui…
TCCWTMS yields best sleep quality improvements among Tai Chi and Baduanjin for sleep disorders
Psychiatry Meta-analysis
TCCWTMS yields best sleep quality improvements among Tai Chi and Baduanjin for sleep disorders Tai Chi and Magnetic Stimulation Improve Sleep Quality
This network meta-analysis of 18 randomized controlled trials compared Tai Chi, Baduanjin, and TCCWTMS for sleep disorders. TCCWTMS showed t…
A review of 18 trials shows that combining Tai Chi with magnetic stimulation may offer the best results for improving sleep quality.
Sleep disturbances and obstructive sleep apnea lower seizure thresholds and impact sleep architecture in epilepsy
Neurology Sys. Review
Sleep disturbances and obstructive sleep apnea lower seizure thresholds and impact sleep architecture in epilepsy Sleep patterns and conditions impact seizure control in epilepsy
This narrative review explores the bidirectional relationship between epilepsy and sleep disorders. It highlights how NREM sleep promotes se…
New insights show how specific sleep stages and conditions like sleep apnea can influence seizure activity and quality of life for people wi…
AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection
Radiology & Imaging Meta-analysis
AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection AI tools show promise for screening obstructive sleep apnea
This meta-analysis of 60 studies evaluated the diagnostic accuracy of AI-based screening tools for obstructive sleep apnea. The analysis fou…
New data shows AI tools can accurately identify obstructive sleep apnea, helping doctors find patients who need treatment more effectively.
Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk
Emergency Medicine Sys. Review
Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk Sleep disorders significantly impact recovery for stroke patients
This narrative review examines the prevalence and impact of sleep disorders, including obstructive sleep apnea (OSA), in stroke patients. Th…
Up to 84% of stroke patients suffer from sleep disorders, which can hinder recovery and increase the risk of future strokes.
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders
Psychiatry Meta-analysis
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders Trazodone may improve sleep quality for people with depression
This exploratory meta-analysis of 5 RCTs and 3 single-arm studies indicates that trazodone improves total sleep time and sleep efficiency wh…
Trazodone may help people with depression get more sleep and fall asleep faster, though it can cause side effects like dizziness and sleepin…

Questions about sleep-disordered breathing

Do children with sleep-disordered breathing benefit from turbinate ablation?

Adding turbinate ablation to adenotonsillectomy does not provide extra benefit for children with sleep-disordered breathing compared to adenotonsillectomy alone.

Full answer →
Can machine learning detect sleep-disordered breathing events as well as experts?

Machine learning models can detect sleep-disordered breathing events with accuracy comparable to expert human scorers, though performance varies slightly depending on the specific task.

Full answer →