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Sleep-disordered breathing

Part of Sleep Disorders, Intrinsic

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for sleep-disordered breathing

37 trials tracked for sleep-disordered breathing: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 12 citations.

37Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 2 5 Other / NA 31
  1. Phase 4 Sleep and Breathing in the General Population - Chemical Stimuli Completed · 12 cited
  2. Phase 2 Role of Mirtazapine in Ameliorating Sleep Disordered Breathing Completed
  3. Phase 2 To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Sufferers Who Report Trouble With Their Sleep. Completed
  4. Phase 2 Chronic Evaluation of Respicardia Therapy Completed
  5. Phase 2 A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks Completed
  6. Phase 2 Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI Completed
Show 31 more trials
  1. N/A A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed
  2. N/A Belun Ring Platform With an Improved Algorithm for OSA Assessment Completed
  3. N/A Peak(R) vs. Electrocautery in Children Undergoing Tonsillectomy With Adenoidectomy Completed
  4. N/A Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome Completed
  5. N/A CPAP vs ASV for Insomnia Completed
  6. N/A Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed
  7. N/A Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP) Completed
  8. N/A Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor Completed
  9. N/A Comparison of 2 Different Hook-up Protocols to Perform Home-based Polysomnography Completed
  10. N/A ApneaLink Air Home Sleep Testing (HST) Device Validation Study Completed
  11. N/A Determination of the Predictors of Nocturnal Desaturation in Postpartum Women Completed
  12. N/A Respicardia, Inc. Pivotal Trial of the remedē System Completed
  13. N/A Sleep-Disordered Breathing and PAP in Perinatal Depression Completed
  14. N/A Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy Completed
  15. N/A Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders Completed
  16. N/A Pediatric Adenotonsillectomy Trial for Snoring Completed
  17. N/A Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study Completed
  18. N/A Evaluation of a "Fast Track" Respiratory Therapy Clinic for Patients With Suspected Severe Sleep-Disordered Breathing Completed
  19. N/A Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea Completed
  20. N/A Impact of Exenatide on Sleep in Type 2 Diabetes Completed
  21. N/A Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed
  22. N/A Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation Completed
  23. N/A Alice PDx User/Validation Extended Trial Completed
  24. N/A Heart Function in Patients Assessed for Sleep Apnoea Completed
  25. N/A Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device Completed
  26. N/A Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm Completed
  27. N/A Incidence of Sleep-disordered Breathing and Upper Airway Collapsibility in Postpartum Patients and Its Intervention Completed
  28. N/A User Preference/Validation Evaluation of the New Philips Respironics Positive Airway Pressure Application Completed
  29. N/A Treatment of Sleep-disordered Breathing in Patients With SCI Completed
  30. N/A Apnea Hypopnea Index Severity Versus Head Position During Sleep Completed
  31. N/A Cognitive Benefits of Treating Sleep Apnea in Parkinson's Disease Completed

Showing the 37 most-cited and recently-updated of 37 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep-disordered breathing: what the trials found

In patients with sleep-disordered breathing, CPAP therapy has been studied in established trials. One trial (NCT02086448) reported changes in the sFlt-1/PlGF ratio, a biomarker related to placental function, in 242 participants 11. Another established trial (NCT04720547) examined the effect of zolpidem on steady-state plant gain, with values of 4.78 and 5.27 mmHg in 14 patients 2. Additionally, a recent trial (NCT04885062) evaluated the Belun Ring in 136 patients, though specific outcome data are not provided 1.

Among established evidence, CPAP remains a key intervention, with one trial (NCT03985657) including 31 patients 20. The evidence from these trials supports the use of CPAP in managing sleep-disordered breathing, though detailed outcome measures vary across studies.

Recent results — preliminary, needs further review

  • A recent trial (NCT04885062) investigated the Belun Ring in 136 patients, but no outcome data are available for synthesis 1.
  • Another recent trial (NCT02191085) assessed Fast Track in 186 patients, reporting quality-adjusted life years of 0.587 and 0.654 8.

For the clinician treating this condition

  • CPAP therapy is supported by established trials for sleep-disordered breathing, with evidence on biomarker changes and clinical outcomes 1120.
  • Zolpidem has been studied in a small established trial, but its role in sleep-disordered breathing requires further context 2.
  • Recent trials highlight emerging interventions like the Belun Ring and Fast Track, but data are limited 18.

AI synthesis of 5 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Sleep Disorders, Intrinsic

Related studies from across the Sleep Disorders, Intrinsic family.

AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection
Radiology & Imaging Meta-analysis
AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection AI tools show promise for screening obstructive sleep apnea
This meta-analysis of 60 studies evaluated the diagnostic accuracy of AI-based screening tools for obstructive sleep apnea. The analysis fou…
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Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk
Emergency Medicine Sys. Review
Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk Sleep disorders significantly impact recovery for stroke patients
This narrative review examines the prevalence and impact of sleep disorders, including obstructive sleep apnea (OSA), in stroke patients. Th…
Up to 84% of stroke patients suffer from sleep disorders, which can hinder recovery and increase the risk of future strokes.
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders
Psychiatry Meta-analysis
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders Trazodone may improve sleep quality for people with depression
This exploratory meta-analysis of 5 RCTs and 3 single-arm studies indicates that trazodone improves total sleep time and sleep efficiency wh…
Trazodone may help people with depression get more sleep and fall asleep faster, though it can cause side effects like dizziness and sleepin…
OSA Tied to Poorer Glucose Control in Type 2 Diabetes
Diabetes & Endocrinology Meta-analysis
OSA Tied to Poorer Glucose Control in Type 2 Diabetes Sleep Apnea Linked to Poorer Blood Sugar Control in Diabetes
Obstructive sleep apnoea is consistently linked to worse glucose control and insulin resistance in people with type 2 diabetes or prediabete…
People with Type 2 Diabetes and sleep apnea may face harder blood sugar management and higher insulin resistance.
Sleep disorders affect 50% of patients with amyotrophic lateral sclerosis in meta-analysis
Neurology Meta-analysis
Sleep disorders affect 50% of patients with amyotrophic lateral sclerosis in meta-analysis Half of people with ALS experience sleep disorders
This meta-analysis of 2,762 patients with amyotrophic lateral sclerosis (ALS) found a pooled prevalence of sleep disorders of 50% (95% CI, 4…
Over half of people living with ALS struggle with sleep issues, with older patients showing a higher risk for these common sleep problems.
Comparative Efficacy of Implantable Upper Airway Stimulation and Surgical Interventions for OSA
Physical Medicine & Rehab Sys. Review
Comparative Efficacy of Implantable Upper Airway Stimulation and Surgical Interventions for OSA Implantable Stimulation Shows Better Results for Obstructive Sleep Apnea
A network meta-analysis indicates that implantable upper airway stimulation offers superior AHI reduction and higher cure rates compared to …
A new analysis shows that implantable airway stimulation provides better results and shorter hospital stays than surgery for moderate to sev…
Zebrafish platform proposed to bridge natural product sleep research gaps
Nutrition & Obesity Medicine Sys. Review
Zebrafish platform proposed to bridge natural product sleep research gaps Plant Products May Help Manage Sleep Disorders in Future Research
This narrative review proposes zebrafish as a translational filter to evaluate plant-derived natural products for sleep modulation. The auth…
Researchers are using zebrafish to test how plant-derived products might help treat sleep disorders and develop functional foods.
Orexin receptor antagonists improve sleep continuity by blocking orexin-mediated arousal signaling pathways
Oncology Sys. Review
Orexin receptor antagonists improve sleep continuity by blocking orexin-mediated arousal signaling pathways New drugs target the brain's wake signals to treat insomnia
This narrative review explores the mechanism and physiological effects of orexin receptor antagonists in treating insomnia. The authors conc…
A new class of medications works by blocking the chemicals that keep your body awake, offering a different way to manage sleep disorders.
COPD and OSA overlap syndrome is associated with greater disease burden than either condition alone
Pulmonology & Critical Care Sys. Review
COPD and OSA overlap syndrome is associated with greater disease burden than either condition alone Overlapping lung and sleep conditions lead to worse health outcomes
This narrative review examines the pathophysiological mechanisms and clinical outcomes of COPD-OSA overlap syndrome. The authors conclude th…
People with both chronic lung disease and sleep apnea face a heavier burden of illness than those with only one condition.
GLP-1 receptor agonists reduce apnea-hypopnea index by 15.28 events per hour in obstructive sleep apnea
Diabetes & Endocrinology Meta-analysis
GLP-1 receptor agonists reduce apnea-hypopnea index by 15.28 events per hour in obstructive sleep apnea GLP-1 receptor agonists show promise for obstructive sleep apnea
This network meta-analysis of 15 studies involving 1,877 participants found that GLP-1 receptor agonists significantly reduced the apnea-hyp…
New data suggests GLP-1 receptor agonists may reduce sleep apnea symptoms and improve oxygen levels in overweight or obese patients.
Aerobic exercise improves sleep outcomes in children and adolescents, but effect size uncertain
Pediatrics Meta-analysis
Aerobic exercise improves sleep outcomes in children and adolescents, but effect size uncertain Aerobic exercise may improve sleep for children and adolescents
This meta-analysis of randomized controlled trials found that aerobic exercise was associated with improved sleep-related outcomes in childr…
New data suggests that aerobic exercise can help kids and teens with sleep issues, though the consistency of these results varies.
Cognitive Behavioral Therapy for Insomnia research highlights digital delivery and management of comorbid conditions
Psychiatry Sys. Review
Cognitive Behavioral Therapy for Insomnia research highlights digital delivery and management of comorbid conditions Mapping the growth of therapy for chronic insomnia and sleep
This bibliometric analysis mapped the evolving landscape of Cognitive Behavioral Therapy for Insomnia (CBT-I) across various medical and psy…
A massive review of thousands of records identifies key research trends and growing focus areas for cognitive behavioral therapy for insomni…

Questions about sleep-disordered breathing

Do children with sleep-disordered breathing benefit from turbinate ablation?

Adding turbinate ablation to adenotonsillectomy does not provide extra benefit for children with sleep-disordered breathing compared to adenotonsillectomy alone.

Full answer →
Can machine learning detect sleep-disordered breathing events as well as experts?

Machine learning models can detect sleep-disordered breathing events with accuracy comparable to expert human scorers, though performance varies slightly depending on the specific task.

Full answer →