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Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritisSpecific exercise volume and intensity may help manage knee osteoarthritis pain

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Key Takeaway
Consider moderate-intensity isotonic exercise to improve function and strength in patients with knee osteoarthritis.

This meta-analysis evaluated the impact of isotonic lower extremity resistance exercise on patients with knee osteoarthritis. The study included a total population of 791 individuals participating in both home-based and center-based programs. The primary outcomes measured were pain, function, and muscle strength. The analysis aimed to determine the optimal intensity and volume of exercise to achieve clinical improvements in this population.

The intervention consisted of isotonic lower extremity resistance exercise. The analysis compared different intensities and volumes of these exercises. Specifically, it looked at the relationship between exercise intensity, the number of repetitions performed, and the resulting improvements in clinical markers. The study did not report a specific comparator group, but rather synthesized data across various programs to identify optimal parameters.

Regarding the primary outcome of pain, the results indicated that very light- to moderate-intensity isotonic exercise produced the greatest reductions in pain. Specifically, greater estimated pain reductions were observed at 6000 repetitions, with a mean difference (MD) of -3.52 (95% CI: -4.08, -2.96). These findings suggest that while lower intensities are effective for pain management, higher volume may enhance the effect.

For the primary outcome of function, moderate-intensity exercise produced the greatest improvements. The peak functional improvements were noted at 2600 repetitions of moderate intensity, resulting in a mean difference (MD) of -16.66 (95% CI: -18.80, -14.51). These results suggest a specific threshold of intensity and volume for optimizing functional outcomes in patients with knee osteoarthritis.

Regarding muscle strength, the results showed that moderate- to vigorous-intensity exercise led to similar gains in muscle strength. The maximal strength gains were observed at 1600 repetitions, with a standardized mean difference (standardized MD) of 0.12 (95% CI: 0.01, 0.22). This indicates that while higher intensity may be required for strength, the volume required for peak gains is lower than that required for pain reduction.

Safety and tolerability data were not reported in the study, including specific rates for adverse events, serious adverse events, or discontinuations. Consequently, the tolerability of these specific exercise volumes and intensities cannot be quantified from this data set.

These findings contribute to the existing body of evidence regarding non-pharmacological management of knee osteoarthritis. While the study identifies specific thresholds for intensity and volume, the evidence is characterized as low to very low-certainty. This means that while the trends for pain, function, and strength are clear, the precision of these specific volume recommendations (e.g., 2600 repetitions) should be interpreted with caution in clinical practice.

Methodological limitations include the low to very low-certainty evidence rating. The lack of reported safety data and the variability in program settings (home-based vs. center-based) may impact the generalizability of the specific repetition counts. Clinical implications suggest that moderate-intensity exercise is a viable intervention for improving function and strength. However, clinicians should recognize that the evidence is not robust enough to mandate specific repetition counts, but rather supports the general use of moderate-intensity isotonic exercise. Questions remain regarding the long-term sustainability of these gains and the specific safety profile of high-volume exercise programs for patients with advanced joint degeneration.

How this fits prior evidence

How this fits prior evidence: This meta-analysis addresses a gap in non-pharmacological management for knee osteoarthritis by providing specific intensity and volume data for isotonic exercise. While previous evidence has explored pharmacological interventions like ozone injections for short to medium term pain, this study focuses on exercise-based outcomes. It complements existing knowledge on knee osteoarthritis management by providing evidence for functional improvement and muscle strength gains through targeted resistance training.

Living with knee osteoarthritis can make daily activities like walking or climbing stairs difficult and painful. For many people, finding the right way to stay active is a constant challenge. They often worry that exercise might cause more pain or that their movements will not be effective. This research looks at how different types of resistance exercises, specifically those involving the lower body, can impact the lives of those dealing with this common joint condition.

To understand these effects, researchers conducted a meta-analysis, which is a study that combines the results of several different trials. They looked at data from 791 people with knee osteoarthritis who participated in various programs, both at home and in clinical centers. The researchers focused on isotonic exercises, which are movements where the muscle stays the same length while it contracts and relaxes. They specifically looked at how the intensity of these exercises and the total number of repetitions performed influenced three main factors: pain levels, physical function, and muscle strength.

The findings suggest that the way a person exercises matters for their specific goals. For example, the study found that very light to moderate intensity exercises were most effective at reducing pain. Specifically, performing around 6,000 repetitions of these lighter exercises showed the greatest reduction in pain. When it came to improving daily function, moderate intensity exercise was most effective, particularly around 2,600 repetitions. For those looking to build muscle strength, both moderate and vigorous intensities showed similar gains, with the most significant gains occurring at around 1,600 repetitions.

While these results are encouraging, it is important to approach them with caution. The researchers noted that the evidence for these findings is of low to very low certainty. This means that while a link was found between these specific exercise routines and better outcomes, the data is not yet strong enough to make definitive claims. There were no reports of serious safety concerns or adverse events in the data reviewed.

For patients today, this means that tailored exercise programs could be a helpful tool. Instead of a one size fits all approach, people with knee osteoarthritis might find relief by focusing on specific intensities based on their goals, such as pain relief versus strength. However, because the evidence is still developing, patients should work closely with a healthcare provider or a physical therapist. These professionals can help create a safe, personalized plan that fits the individual's specific needs and physical abilities.

What this means for you:
Specific types of resistance exercise may help manage knee osteoarthritis pain and improve muscle strength.

Study Details

Study typeMeta analysis
Sample sizen = 791
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
We aimed (1) to estimate the dose-response relationships between isotonic lower extremity resistance exercise volume and outcomes of pain, function, and strength in people with knee osteoarthritis (OA) and (2) to compare different intensities and delivery methods of isotonic resistance exercise for patients with knee OA. Systematic review with dose-response meta-analysis of randomized controlled trials (RCTs). MEDLINE (Medical Literature Analysis and Retrieval System Online)/PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), Web of Science, CINAHL (Cumulative Index of Nursing and Allied Health), and EMBASE (Excerpta Medica Database) were searched from inception to January 2, 2025. RCTs evaluating isolated isotonic resistance training without other exercise interventions in people with knee OA were included. Pain, function, and muscle strength were analyzed. Risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool; certainty of evidence, using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach; and dose-response relationships, using restricted cubic spline models. Twenty RCTs were included (n = 791). Low- to very low-certainty evidence indicated that isotonic resistance training may reduce pain, improve function, and increase muscle strength in people with knee OA. Very light- to moderate-intensity isotonic exercise produced the greatest reductions in pain; moderate-intensity, the greatest improvements in function; and moderate- to vigorous-intensity, similar gains in muscle strength. Benefits were seen with home- and center-based programs; the effects were more pronounced with center-based programs. For the dose-response analyses, there was a nonlinear relationship, with greater estimated pain reductions at 6000 repetitions (mean difference [MD], -3.52; 95% confidence interval [CI]: -4.08, -2.96), peak functional improvements at 2600 repetitions of moderate intensity (MD, -16.66; 95% CI: -18.80, -14.51), and maximal strength gains at 1600 repetitions (standardized MD, 0.12; 95% CI: 0.01, 0.22). Isotonic resistance training may improve pain, function, and muscle strength in people with knee OA. Moderate-intensity exercise and specific training volumes were associated with the greatest estimated benefits, although the certainty of evidence was low to very low. .
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