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Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program.

Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide…
Photo by Rohit Choudhari / Unsplash
Key Takeaway
Note that structured rehabilitation reduced pain in 52% of patients with hip or knee osteoarthritis at 3 months in a Danish program.

This observational cohort study included 23,021 consecutive eligible adults with hip or knee osteoarthritis participating in a nationwide GLA:D osteoarthritis management program in Denmark. The intervention consisted of a structured rehabilitation program delivered by trained healthcare professionals. No specific comparator group was reported for this analysis.

At 3 months of follow-up, 52% of patients reported a 30%+ reduction in pain intensity on a 0-100 VAS. The study also assessed therapist effects using a variance partition coefficient (ICC), which was 0.007 in the null model with a 95%CI of 0.005 to 0.009. No specific p-values or absolute numbers for the primary outcome were provided in the data.

Safety and tolerability data, including adverse events, serious adverse events, discontinuations, and specific tolerability metrics, were not reported. The study did not establish causality between the intervention and outcomes. Therapist effects made a minimal contribution to variation in patient outcomes within this nationally implemented program.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
Objective: Unlike several other fields of healthcare, little is known about the size of therapist effects on patient outcomes following rehabilitation for musculoskeletal conditions. We aimed to estimate the proportion of variance in patient outcomes from a structured rehabilitation program explained by therapist effects. Methods: For our observational cohort study we accessed data from the national multicentre Good Life with osteoArthritis in Denmark (GLA:D) osteoarthritis management program. Analyses included 23,021 consecutive eligible adults with hip or knee osteoarthritis (mean (SD) age 65.0 (9.8) years, 71% female) treated by 657 therapists between October 2014 and February 2019. The primary outcome was 30%+ reduction in pain intensity on 0-100 VAS at 3 months. Therapist effects were estimated as the variance partition coefficient (intra-class correlation coefficient (ICC)) from two-level random intercept logistic regression models before and after adjusting for patient-level case-mix factors and therapist-level characteristics (number of patients treated, days since therapist certification). Analyses were repeated for a range of secondary outcomes using multiply imputed data and complete-case analysis. Results: 52% of patients reported a 30%+ reduction in pain intensity on 0-100 VAS at 3 months. In the null model the ICC was 0.007 (95%CI: 0.005, 0.009), which changed little after adjusting for patient- and therapist-level covariates. Upper confidence limits for ICC estimates across all secondary outcomes in multiply imputed and complete case analyses were less than 0.03. Conclusions: In a nationally implemented osteoarthritis management program delivered by trained healthcare professionals, therapist effects made a minimal contribution to variation in patient outcomes.
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