Intact Fish Skin Graft improves wound area reduction vs standard care in Stage 3-4 pressure ulcers
This retrospective matched cohort study analyzed deidentified electronic health record data from the U.S. Wound Registry, including 80 patients with Stage 3-4 pressure ulcers (40 per group). Patients were treated with either Intact Fish Skin Graft (IFSG) or Standard of Care (SOC), with outcomes assessed for percent area reduction (PAR), healed status, and healed or improved rate. Follow-up duration was not reported.
Main results showed IFSG was associated with superior PAR (49% vs 34% for SOC, p=0.0028) and a higher healed or improved rate (67.5% vs 55.0%, p=0.0379). Complete healing occurred in 45.5% of IFSG patients versus 33.3% with SOC, but this difference did not reach statistical significance. Effect sizes and absolute numbers for these outcomes were not reported.
Safety and tolerability data, including adverse events, serious adverse events, and discontinuations, were not reported. Key limitations include a high-risk, real-world cohort with only 37.5% ambulatory patients and a high prevalence of multiple concurrent wounds, which may affect generalizability. Funding and conflicts of interest were not reported.
Practice relevance is that this study supports the use of IFSG as an effective advanced therapy for hard-to-heal pressure ulcers, based on observational evidence. However, the retrospective design and lack of safety data mean results should be interpreted with restraint, and the non-significant difference in complete healing highlights the need for further research to confirm benefits.
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