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Administrative MDT interventions reduced prophylactic antibiotic use in Class I incisions across three study phasesSurgery Patients Are Getting Fewer Unneeded Antibiotics

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Key Takeaway
Consider administrative MDT interventions to reduce prophylactic antibiotic use in Class I incisions, noting observational study limitations.

This retrospective-prospective cohort study examined patients with Class I (clean) incisions within a healthcare system utilizing administrative Multi-departmental team (MDT) interventions. The study spanned three phases: baseline in 2017 (21,259 patients), Phase II from January 2020 to December 2022 (83,804 patients), and Phase III from January 2023 to December 2024 (76,259 patients). The comparator was baseline monitoring results from 2017.

The primary outcome measured the prophylactic antibiotic use rate for Class I incisions. Results demonstrated a decrease from 33.72% at baseline to 29.01% in Phase II and 25.91% in Phase III. Absolute numbers were 7,168 out of 21,259 at baseline, 24,314 out of 83,804 in Phase II, and 19,757 out of 76,259 in Phase III. The p-value for this decrease was 0.000.

Safety data, including adverse events, serious adverse events, discontinuations, and tolerability, were not reported. Key limitations include the observational nature of the study and the lack of reported causality or funding information. The practice relevance involves evaluating the use of perioperative prophylactic antibiotics in Class I incisions after implementing administrative MDT interventions.

  • Antibiotic use dropped 8% after team-led hospital changes
  • Helps all patients facing clean surgeries like hernia or joint repair
  • Already in use—hospitals can adopt this model now

This new hospital strategy could protect surgery patients from avoidable risks linked to unnecessary antibiotics.

Imagine your mom is about to have a routine surgery—say, a knee replacement. It’s low-risk, and she’s healthy. But before the operation, she’s given antibiotics “just in case.” That used to be common. But now, hospitals are rethinking that habit—and patients are safer because of it.

Here’s why: antibiotics aren’t harmless. When used when they’re not needed, they can cause side effects or even lead to dangerous superbugs. And that’s exactly what doctors are trying to stop.

Millions of people have what doctors call “clean” surgeries every year. These include procedures like removing a small lump, fixing a hernia, or replacing a joint. The incision is clean, and the risk of infection is already very low.

In these cases, giving antibiotics before surgery used to be routine. But overuse has a cost. It doesn’t just raise the risk of side effects—it also fuels antibiotic resistance. That means real infections later could be harder to treat.

Patients often don’t know they’re getting antibiotics “just in case.” And until recently, many hospitals didn’t track this closely.

The surprising shift

Hospitals used to assume more antibiotics meant safer surgery. But research now shows that’s not true—for clean surgeries, antibiotics often do more harm than good.

Here’s the twist: one hospital found that simply bringing together leaders from different departments—pharmacy, infection control, surgery, and nursing—led to big changes in how antibiotics were used.

Think of antibiotics like a security team. They’re great when there’s a real threat—like an active infection. But if you send them in when there’s no danger, they can cause chaos. They might attack good bacteria, cause rashes or diarrhea, or train germs to become stronger.

The hospital created a “watchdog” team—doctors, pharmacists, and nurses from different departments. They reviewed how antibiotics were being used. They shared results with staff. They offered training. And they kept checking.

It’s like putting up a dashboard in a car that shows fuel use. When people can see the numbers, they drive more efficiently.

Researchers looked at over 180,000 surgeries from 2017 to 2024. All were Class I (clean) incisions. The study tracked how often antibiotics were given before surgery, whether they were stopped on time, and if the right drug was used.

The hospital rolled out changes in phases. First, a small team reviewed practices. Then, they expanded to include nurses, anesthesiologists, and surgeons. Finally, they kept monitoring to make sure improvements stuck.

Before the changes, about 34% of clean surgery patients got antibiotics they didn’t need. After the first phase of the program, that number dropped to 29%. By the final phase, it fell even more—to 26%.

That may sound small. But think of it this way: for every 100 patients, 8 fewer got unnecessary drugs. That’s 8 fewer chances for side effects or resistance.

The right antibiotic was used more often. And doctors stopped them sooner. That’s important—because even a short delay in stopping can increase risk.

This doesn’t mean this treatment is available yet.

What scientists didn’t expect

They thought a top-down rule might work. But what actually made the difference was teamwork.

When pharmacists talked to surgeons, and nurses joined the conversation, habits changed. It wasn’t about blame—it was about shared goals.

Experts say this model could work in other hospitals, even outside the U.S. The key wasn’t new drugs or tech—it was better coordination.

If you or a loved one is having a clean surgery, it’s okay to ask: “Will I get antibiotics? Are they really needed?”

Hospitals using this team approach are already reducing unnecessary use. You can ask if your hospital tracks antibiotic use for clean surgeries.

No need to demand change—but it’s smart to be informed.

The hard truth

Not every hospital has this system. The study was done at one medical center. Most results came from a single country. And while the numbers improved, 26% is still too high.

Also, the study looked back at records. It wasn’t a randomized trial. So we can’t say for sure that the team caused all the change—though the timing makes it likely.

What’s next

The hospital plans to keep tracking results through 2024. Other centers are starting to copy the model. The hope is that more hospitals will form these cross-department teams to improve care.

It may take years for this approach to spread widely. But the good news? It doesn’t require expensive tools—just better teamwork.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
BackgroundPerioperative antibiotic prophylaxis plays a key role in preventing surgical site infections (SSIs). However, inappropriate use may increase the risk of antimicrobial resistance and SSIs. This study aims to evaluate the use of perioperative prophylactic antibiotics in Class I incisions after implementing administrative multidisciplinary team (MDT) interventions and assess the effectiveness of these interventions in improving management practices.MethodsRetrospective collection of perioperative data from 2017 served as baseline data. The administrative intervention was divided into three phases: Phase I: The administrative Multi-departmental team (MDT) was composed of Medical Affairs Department, Hospital Infection Management Department, and Pharmacy Department (January 2018–December 2019). During this phase, the three departments will collaboratively conduct surveillance, evaluation, and public reporting on perioperative antimicrobial prophylaxis for Class I (clean) incisions and organize targeted training initiatives based on the findings. Phase II: The “administrative MDT” model will now be comprehensively expanded and integrated into key areas of our healthcare system, encompassing the Nursing department, Operating room, Anesthesiology department, and various clinical units. This strategic development will span a multi-department joint intervention phase, commencing from January 2020 and concluding in December 2022; Simultaneously, targeted improvement measures were implemented to address issues identified in Phase I. Phase III: Continuous follow-up (January 2023–December 2024), To evaluate the improvement effectiveness of each intervention phase compared to the baseline monitoring results.ResultsAfter administrative interventions, all monitoring indicators for prophylactic antibiotic use in Class I incisions showed significant improvement: The prophylactic antibiotic use rate for Class I incisions decreased from 33.72% (7,168/21259) at baseline to 29.01% (24,314/83804) in Phase II and further to 25.91% (19,757/76259) in Phase III, which were statistically significant different (p = 0.000 
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