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Jet lidocaine reduces anxiety during peripheral venous access in meta-analysis of 5 trialsJet Lidocaine Reduces Anxiety During Blood Draws

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Key Takeaway
Consider jet lidocaine for reducing anxiety during peripheral venous access, but note pain reduction was not statistically significant.

This meta-analysis of 5 randomized controlled trials evaluated the effect of jet lidocaine on anxiety and pain during peripheral venous access. The primary outcome was anxiety, which was significantly reduced with jet lidocaine compared to control (standardized mean difference -1.031; 95% CI -1.653 to -0.409; P =.001). The secondary outcome of pain showed a reduction that did not reach statistical significance (SMD -0.817; 95% CI -1.817 to 0.182; P =.109).

Adverse events were not reported in the included trials. The authors note limitations including the need for larger sample sizes and standardized protocols across studies. The evidence suggests jet lidocaine may be an effective option for reducing anxiety during peripheral venous access, but the effect on pain remains uncertain.

Clinicians should consider jet lidocaine as a potential intervention for anxiety reduction in this setting, but the lack of data on safety and the non-significant pain outcome warrant cautious interpretation. Further research with larger, well-designed trials is needed to confirm these findings and establish optimal protocols.

How this fits prior evidence

This meta-analysis extends prior findings on lidocaine for procedural pain and anxiety. Previous coverage showed lidocaine cream combined with the Valsalva maneuver had high SUCRA probability for reducing needle puncture pain, and intrauterine lidocaine reduced pain during hysteroscope insertion. The current analysis focuses on jet lidocaine for peripheral venous access, confirming a significant anxiety reduction but not a significant pain reduction, contrasting with the exploratory pain benefit seen with lidocaine cream plus Valsalva. It also addresses a gap by evaluating a different formulation and route of lidocaine administration.

Getting an IV or having blood drawn can be stressful. A new analysis of five clinical trials suggests that a needle-free device that sprays lidocaine into the skin may help reduce anxiety during these procedures.

The analysis combined results from 5 randomized controlled trials. The studies looked at people of all ages who needed a needle inserted into a vein. The device, called jet lidocaine, delivers numbing medication without a needle. The researchers measured anxiety and pain levels.

They found that jet lidocaine significantly lowered anxiety compared to a placebo or no treatment. The effect was strong and consistent across the studies. However, the same was not true for pain. The reduction in pain was not statistically significant, meaning the difference could have been due to chance.

No safety concerns were reported in the trials, but the analysis did not detail side effects. The researchers note that larger studies with standardized methods are needed to confirm these findings. For now, jet lidocaine appears to be a promising option for reducing anxiety during needle procedures, but it should not be relied on for pain relief.

What this means for you:
Jet lidocaine may help with needle anxiety but not pain; more research is needed.

Common questions

What is jet lidocaine?

Jet lidocaine is a needle-free device that sprays lidocaine, a numbing medication, into the skin. It is used to reduce discomfort during procedures like getting an IV or having blood drawn.

Does jet lidocaine reduce pain?

In this analysis, jet lidocaine did not significantly reduce pain during peripheral venous access. The reduction in pain was not statistically significant, meaning it may have been due to chance.

How many studies were included in this analysis?

The analysis included 5 randomized controlled trials. The researchers noted that larger studies with standardized protocols are needed to confirm the findings.

Is jet lidocaine safe?

The analysis did not report any adverse events or safety concerns. However, the safety data were not detailed, so it is important to discuss any risks with your healthcare provider.

Study Details

Study typeMeta analysis
EvidenceLevel 1
View Original Abstract ↓
OBJECTIVE: The aim of this study was to determine the effect of jet lidocaine on pain and anxiety during peripheral venous access. METHODS: A comprehensive literature search was conducted in PubMed, Web of Science, EBSCOhost, Google Scholar, and the YÖK Thesis Center without year limitation. Five randomized controlled trials that met the inclusion criteria were included in the analysis. Data extraction and methodological quality assessment were performed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools, and study selection was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The findings were synthesized using meta-analysis and narrative synthesis. RESULTS: The pooled analysis demonstrated that jet lidocaine significantly reduced anxiety related to peripheral venous access (standardized mean difference: -1.031; 95% confidence interval: -1.653 to -0.409; Z = -3.249; P = .001; I2 = 89.98%). However, its effect on pain was not statistically significant (standardized mean difference: -0.817; 95% confidence interval: -1.817 to 0.182; Z = -1.602; P = .109; I2 = 96.57%). CONCLUSION: Jet lidocaine may be an effective option for reducing anxiety during peripheral venous access; however, its effect on pain was not statistically significant. Further high-quality randomized controlled trials with standardized protocols and larger sample sizes are needed to clarify its analgesic effectiveness and clinical outcomes.
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