Living with schizophrenia often involves more than just active symptoms. Many people struggle with cognitive impairment, which affects memory and thinking, along with negative symptoms like a lack of motivation or emotional expression. These challenges can make daily life and social connection much harder.
A review of data from 730 patients found that certain medications, known as 5-HTR antagonists, showed a moderate effect in improving these specific areas. These medications included setrons, CVN058, and vortioxetine. The results showed that these drugs performed significantly better than a placebo when treating both cognitive issues and negative symptoms.
While these results are encouraging, the findings come from a meta-analysis, which combines data from several studies. Because the evidence is still developing, experts say we need more large, multi-center studies to confirm these results. For now, these findings suggest that these specific medications could be a helpful addition to current treatment plans.
