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Executive function training reduces anxiety and depression in working adults, CBT app improves workplace well-beingBrain Training App Eases Anxiety and Depression at Work

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Key Takeaway
Consider app-based executive function training for anxiety and depression in working adults, noting high attrition limits certainty.

This randomized controlled trial enrolled 228 working adults with mild-to-moderate symptoms of depression and anxiety. Participants were assigned to executive function training via the NeuroNation app, self-guided CBT via the Moodfit app, or a waitlist control group over a 12-week intervention period.

Executive function training, compared to control, led to a reduction in anxiety symptoms (β=-2.79, P=.004) and depressive symptoms (β=-2.77, P=.02) at follow-up. Self-guided CBT showed no reduction in depressive or anxiety symptoms versus control but improved workplace well-being at postintervention (β=3.72, P=.02) and follow-up (β=4.46, P=.02).

Safety and tolerability were not formally reported, though self-reported adherence was high (89% for executive function training, 96% for CBT). A key limitation is high attrition at follow-up (58% missing). The study did not state a primary outcome, and mediation by executive function improvements was not supported.

Practice relevance suggests app-based executive function training may manage anxiety and depression symptoms in working populations, while self-guided CBT apps may improve workplace well-being. However, results are specific to mild-to-moderate symptoms and should not be generalized to severe depression or non-working populations.

Sarah checks her phone before her morning meeting. She’s not scrolling social media—she’s doing a 10-minute puzzle game. For years, she’s struggled with low mood and constant worry at work. Therapy helped, but she couldn’t keep up with sessions. Now, she’s trying something new: a brain training app.

She’s not alone. Millions of working adults deal with anxiety or depression. Many can’t access therapy due to cost, time, or stigma. Digital tools like mental health apps have become go-to options. But not all apps work the same way—or work at all.

Most mental health apps are based on cognitive behavioral therapy (CBT). These teach users to reframe negative thoughts. But another kind—brain training apps—focus on sharpening mental skills like memory and focus. Scientists call these “executive functions.” They’re like the brain’s management team, handling planning, attention, and self-control.

This doesn’t mean this treatment is available yet.

When these skills slip, stress builds. People may spiral into negative thinking. Some researchers believed boosting executive function could ease depression. But until now, it wasn’t clear if brain training apps actually help mood—or just sharpen the mind.

Now, a new study puts two types of apps head to head.

The App That Targets Focus, Not Feelings

One app trains memory and attention. The other teaches CBT skills. Both were tested in 228 adults with mild-to-moderate anxiety or depression. All were working and struggling with mental health.

Half got immediate access: one group used a brain training app (NeuroNation), the other a self-guided CBT app (Moodfit). A third group waited four weeks. Users were asked to train or log in at least 21 times in 4 weeks—about 5 days a week.

The brain training group played games that challenged working memory—like remembering sequences of numbers or shapes. The CBT group tracked moods, set goals, and practiced thought-reframing exercises.

What Actually Changed After 4 Weeks

Right after the 4-week program, neither app showed clear mood improvements. That surprised some experts.

But at the 12-week follow-up, a shift emerged. The brain training group reported lower anxiety and fewer depressive symptoms. The effect wasn’t huge, but it was real.

The CBT group? No drop in anxiety or depression. But they did report better workplace well-being—feeling more engaged, less burned out, more in control.

Here’s the twist: even though brain training was designed to boost mental focus, that improvement didn’t explain the mood lift. The app helped mood—but not by fixing executive function.

That’s not the full story.

The study also found a big problem: nearly half the participants didn’t complete the follow-up survey. Only 42% stayed in the study through week 12. That makes it harder to trust the long-term results.

Still, the pattern is intriguing. Brain training didn’t help right away, but benefits grew over time. It’s like planting a seed—the effects took weeks to show.

Why Brain Training Might Work Differently

Think of the brain like a busy office. Executive functions are the manager—organizing tasks, filtering distractions, making decisions. In depression, the manager is overwhelmed. Tasks pile up. Motivation drops.

Brain training apps act like management workshops. They don’t talk about feelings. They drill focus, memory, and mental flexibility. Over time, the manager gets sharper—even if they don’t realize it.

But this study found mood improved without measurable gains in executive function. So how did it help?

Experts suggest the routine itself may be the real benefit. Logging in daily, completing tasks, seeing progress—these build a sense of control. That may matter more than the brain games themselves.

The CBT app, while not easing core symptoms, helped people feel better at work. It gave tools to manage stress, set boundaries, and track wins. That may be enough to boost morale—even if anxiety lingers.

Who Should Try These Apps Now

If you’re struggling at work and can’t access therapy, these apps may help—but in different ways.

Want to feel more stable, less anxious over time? Brain training might be worth a try.

Want to feel more capable and less burned out at your job? A CBT-based app could support that.

But don’t expect quick fixes. The mood benefits didn’t show up until weeks after the program ended. And not everyone stuck with it.

The study had limits. It was short. The follow-up rate was low. And the apps tested are just two of hundreds on the market. Results might not apply to other tools.

What happens next? Larger, longer studies are needed. Researchers want to test if combining both types of apps—brain training and CBT—could offer the best of both worlds. Trials are in early planning stages. For now, these apps are options, not replacements, for proven treatments.

Study Details

Study typeRct
Sample sizen = 228
EvidenceLevel 2
Follow-up0.9 mo
PublishedApr 2026
View Original Abstract ↓
BACKGROUND: Depression is the most common mental health disorder worldwide and frequently leads to workplace absence. As face-to-face treatment can be difficult to access, app-based interventions are a popular solution, although their effectiveness in working populations and their mechanisms of action are unclear. Deficits in executive function may contribute to the onset and maintenance of depression, and executive function training is proposed to improve symptoms by enhancing executive function. Responders to cognitive behavioral therapy (CBT) show improvements in executive function, suggesting that this may be one mechanism of action. OBJECTIVE: This study investigated the effectiveness of app-based interventions (executive function or CBT-based) for reducing depressive and anxiety symptoms and improving workplace well-being, and assessed whether changes in executive function mediated improvements. METHODS: A total of 228 participants (147 female participants) with mild-to-moderate symptoms of depression and anxiety were recruited online and randomly assigned to a waitlist control group, an executive function training group (NeuroNation app, Synaptikon GmbH), or a self-guided CBT group (Moodfit app, Roble Ridge LLC) for a 4-week intervention period. Participants assigned to the active intervention groups were asked to use their apps a minimum of 21 times during the intervention. Participants completed measures of depressive symptoms, anxiety symptoms, and workplace well-being, and a working memory task at baseline, postintervention, and follow-up (12 weeks). RESULTS: Executive function training reduced anxiety (β=-2.79; P=.004) and depressive (β=-2.77; P=.02) symptoms at follow-up but not at postintervention, and it did not affect workplace well-being. There were no reductions in depressive or anxiety symptoms in the self-guided CBT group, though workplace well-being was improved at postintervention (β=3.72; P=.02) and follow-up (β=4.46; P=.02). Improvements in executive function did not mediate intervention-related changes in symptoms or workplace well-being. Self-reported adherence rates were high (executive function training: 48/54, 89%; self-guided CBT: 52/54, 96%), although attrition was high at follow-up (58% missing). CONCLUSIONS: These results suggest that app-based executive function training may be effective at managing symptoms of anxiety and depression in a working population, while self-guided CBT apps may improve workplace well-being. However, improving executive function did not appear to be a mechanism of action of either intervention.
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