Mode
Text Size
Log in / Sign up

Meta-analysis finds distinct hedonic deficits in schizophrenia and depressionHow do depression and schizophrenia change how we look forward to things?

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider distinct patterns of anticipated pleasure and displeasure in schizophrenia versus depression as observational associations.

This meta-analysis examined anticipated hedonic deficits (anticipated pleasure and anticipated displeasure) across clinical and subclinical individuals of the schizophrenia spectrum, clinical and subclinical individuals of depression, and controls. The analysis included 1,464 participants for the schizophrenia spectrum anticipated pleasure analysis. No specific intervention or exposure was reported; the analysis compared these groups against controls.

For the schizophrenia spectrum (clinical and subclinical), participants reported significantly less anticipated pleasure than controls (Hedges' g = -0.22, p = 0.032). They reported similar levels of anticipated displeasure as controls (g = 0.09, p = 0.345). For depression (clinical and subclinical), participants anticipated significantly less pleasure than controls (g = -0.62, p = 0.003) and significantly more displeasure (g = 0.82, p = 0.033). Comparisons of effect sizes between schizophrenia and depression samples showed no significant differences for either anticipated pleasure or anticipated displeasure.

Safety and tolerability data were not reported. Key methodological details such as study setting, follow-up duration, and primary outcome were also not reported. The analysis is based on observational studies, establishing associations rather than causation. The authors suggest social anticipated pleasure may be a potential screening target for schizophrenia, while impaired anticipated emotions may serve as a marker for depression. Clinical application of these findings should be restrained, as they represent group-level statistical associations from heterogeneous samples.

Imagine looking at your calendar and feeling a sense of dread about upcoming events, or a flatness where excitement should be. That's what this research is about—how people with depression and schizophrenia anticipate pleasure and displeasure from future experiences. The analysis pooled data from over 1,400 participants across multiple studies.

It found that people on the schizophrenia spectrum, including those with clinical and subclinical symptoms, reported expecting less pleasure from future social events compared to people without these conditions. However, they didn't expect more displeasure. In contrast, people with depression expected both less pleasure and more displeasure from what was coming. The effect was more pronounced for displeasure in depression.

This was a meta-analysis, which means it combined results from existing observational studies. That's a strength for spotting patterns, but it can't tell us what causes these differences in anticipation. The study also didn't track whether these patterns change with treatment or over time. The findings help map the emotional landscape of these conditions, showing that a lack of motivation might be rooted in how the future is felt before it even arrives.

What this means for you:
Depression dims future pleasure and amplifies displeasure, while schizophrenia mainly dims pleasure.

Study Details

Study typeMeta analysis
Sample sizen = 1,464
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Anhedonia, a transdiagnostic symptom for schizophrenia and depression, exists in subclinical individuals at risk of the two disorders. Prior meta-analytic reviews seldom considered both anticipated pleasure and anticipated displeasure. We conducted a three-level meta-analysis on anticipated pleasure and displeasure in people with schizophrenia and depression, and their subclinical counterparts. Clinical and subclinical individuals of the schizophrenia spectrum reported less anticipated pleasure than controls (k = 37, 1464 participants, g = -0.22, p = 0.032), but reported similar anticipated displeasure as controls (k = 20, 769 participants, g = 0.09, p = 0.345). Clinical and subclinical individuals of depression anticipated less pleasure (k = 21, 1162 participants, g = -0.62, p = 0.003) and more displeasure (k = 15, 954 participants, g = 0.82, p = 0.033) than controls. Comparisons of the schizophrenia and depression samples yielded no significant difference for effect sizes of either anticipated pleasure or anticipated displeasure. For schizophrenia spectrum, heterogeneity of anticipated pleasure was explained by sociality of anticipated stimuli. For participants with depression, higher severity of depressive symptoms were associated with larger between-group effects on anticipated pleasure and displeasure. After accounting for publication bias, the between-group effects remained of a similar magnitude. We elucidated the patterns of impaired anticipated emotions in clinical and subclinical samples of the schizophrenia and depression. Social anticipated pleasure may be a potential screening target for schizophrenia, while impaired anticipated emotions may serve as a marker for depression.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.