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Patient Questions

Real questions from health communities, answered with cited research from PubMed and Vellito's article corpus. Plain language, no medical advice. How this works.

Rheumatology

How does the mortality risk for microscopic polyangiitis compare to granulomatosis with polyangiitis?

Microscopic polyangiitis (MPA) generally carries a higher mortality risk than granulomatosis with polyangiitis (GPA), with studies showing poorer survival and higher hazard…

Cardiology

Does having ANCA-associated vasculitis increase my risk of heart problems and death?

Having ANCA-associated vasculitis significantly increases your risk of heart attacks, strokes, blood clots, and death compared to people without the disease.

Rheumatology

Which type of ANCA-associated vasculitis has the worst prognosis for patients?

Microscopic polyangiitis (MPA) has the worst long-term prognosis among the types of ANCA-associated vasculitis, with lower five-year survival rates compared to other subtypes.

Rheumatology

Are patients with granulomatosis with polyangiitis at higher risk for cardiovascular events?

Patients with granulomatosis with polyangiitis face a significantly higher risk of cardiovascular events like heart attacks and strokes compared to the general population.

Hematology

Can Lynch Syndrome cause cancer in my bladder or kidney?

Yes, Lynch syndrome increases the risk of bladder and kidney cancers, especially in people with MSH2 mutations.

Hematology

Do non-clotting factor therapies work for both Hemophilia A and Hemophilia B?

Non-clotting factor therapies like emicizumab and concizumab are effective for preventing bleeding in both Hemophilia A and Hemophilia B.

Gastroenterology

Does having Lynch Syndrome mean I will definitely get colon cancer?

Having Lynch Syndrome greatly increases your risk of colon cancer, but it does not mean you will definitely get it. Regular colonoscopies can lower the chance of dying from the…

Genetics & Precision Medicine

What specific gene mutations are found in families with suspected Lynch Syndrome?

Families with suspected Lynch Syndrome typically carry germline mutations in four specific DNA mismatch repair genes: MLH1, MSH2, MSH6, and PMS2.

Hematology

How much does gene therapy reduce bleeding rates for adults with severe Hemophilia A?

Gene therapy reduces annualized bleeding rates in adults with severe Hemophilia A by a standardized mean difference of -0.72 compared to standard factor treatment, though…

Oncology

How does lifileucel TIL therapy work for patients with metastatic melanoma?

Lifileucel is a cell therapy that uses your own immune cells to fight metastatic melanoma after other treatments fail. It involves removing tumor cells, growing immune cells in a…

Hematology

Do non-clotting factor therapies actually reduce bleeding in congenital Hemophilia A?

Yes, non-clotting factor therapies like emicizumab and concizumab significantly reduce bleeding rates in people with congenital Hemophilia A compared to no treatment or standard…

Neurology

Does the surveillance report describe acute flaccid myelitis cases happening in the United States?

Yes, surveillance reports confirm acute flaccid myelitis cases occurred in the United States from 2014 through 2022, with clusters appearing in states like Minnesota, Texas, and…

Pediatrics

How did U.S. surveillance define acute flaccid myelitis in children during the EV-D68 outbreak?

U.S. surveillance defined acute flaccid myelitis in children as a distinct syndrome of acute paralysis linked to enterovirus D-68 outbreaks, requiring spinal cord lesions limited…

Infectious Disease

Can T cell epitope vaccines help control dengue virus infection?

T cell epitope vaccines show promise for controlling dengue by boosting cellular immunity and potentially reducing the risk of severe disease caused by antibody-dependent…

Neurology

Did U.S. surveillance data from 2014 define acute flaccid myelitis as a distinct entity in children?

Yes, U.S. surveillance data from 2014 defined acute flaccid myelitis as a distinct entity in children following an outbreak linked to enterovirus D68.

Infectious Disease

Why did blastomycosis cases increase in some areas during the pandemic?

Blastomycosis cases increased during the pandemic because people spent more time outdoors and in areas with damp soil, which releases the fungus into the air.

Infectious Disease

What does the 2019 surveillance report say about blastomycosis in the US?

The 2019 surveillance report documents the number of blastomycosis cases in the United States, noting that these infections are often found alongside other fungal diseases like…

Cardiology

Does having a prior history of atrial fibrillation increase sudden cardiac death risk?

Yes, a prior history of atrial fibrillation is linked to a higher risk of sudden cardiac death, especially in patients with heart attack or heart failure.

Infectious Disease

Are there more blastomycosis cases now compared to before the pandemic?

Data from 2019 and during the pandemic show that blastomycosis cases did not increase significantly compared to pre-pandemic levels.

Infectious Disease

Can a cave visit cause a histoplasmosis infection?

Yes, visiting a cave can cause a histoplasmosis infection because these caves often contain bat guano where the fungus lives.

Primary Care & Family Medicine

What happened to a family of 12 who visited Costa Rica caves?

Twelve members of an extended family developed suspected histoplasmosis after visiting caves in Costa Rica.

Infectious Disease

How well did the random forest model perform for Varicella?

A random forest model predicted pediatric varicella encephalitis with an area under the curve of 0.950, showing excellent performance in a study of 201 children.

Infectious Disease

Are histoplasmosis cases tracked alongside other fungal infections in the US?

Yes, histoplasmosis is tracked alongside coccidioidomycosis and blastomycosis in US surveillance reports.

Infectious Disease

Does the field report describe new Varicella testing in Minnesota?

Yes, a field report confirms that the Minnesota Department of Health has expanded laboratory testing for varicella.

How this works

We pull real patient questions from public Reddit health communities (r/AskDocs, r/diabetes, r/menopause, etc.). Each question is rewritten into a generic medical question (no personal details), then answered by an AI using only cited sources from Vellito's article database and PubMed. A second AI independently scores each answer for accuracy and citation fidelity before publication. Answers below the safety threshold or touching emergency, dosing, or pediatric topics are queued for human review and never auto-published.

This is not medical advice. Always speak with your own doctor before making decisions about your health.