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Electroacupuncture ranks highest for total efficacy in acupuncture interventions for polycystic ovary syndromeAcupuncture Methods Show Varying Success for Polycystic Ovary Syndrome

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Key Takeaway
Note that electroacupuncture ranks highest for total efficacy in acupuncture interventions for polycystic ovary syndrome.

This network meta-analysis synthesized data from 92 randomized controlled trials to evaluate various acupuncture-based interventions, including electroacupuncture, filiform needle, and moxibustion techniques, for the management of polycystic ovary syndrome (PCOS). The analysis utilized SUCRA rankings to compare the relative efficacy of these modalities across several clinical outcomes.

For total efficacy (TE), electroacupuncture achieved the highest ranking at 99.03%, followed by filiform needle plus thunder fire moxibustion (74.77%) and filiform needle with electroacupuncture (64.02%). Specific hormonal markers also showed distinct rankings: fire needle was ranked highest for follicle-stimulating hormone (FSH) regulation (90.99%), while warming needle moxibustion led in luteinizing hormone (LH) regulation (86.75%). For testosterone reduction, filiform needle plus moxibustion ranked highest (96.53%).

The authors noted that modalities incorporating electrical, thermal, or sustained stimulation appear more effective than others. However, no statistically significant differences were observed between single and combined acupuncture therapies. The findings are constrained by the methodological limitations of the included studies. High-quality, rigorously designed RCTs are required to validate these results for clinical practice.

How this fits prior evidence

This meta-analysis addresses a gap in identifying the most effective non-pharmacological interventions for polycystic ovary syndrome. While previous evidence has established pharmacological options such as GLP-1 receptor agonists and metformin for weight reduction, and identified potential adjunctive treatments like astaxanthin to address oxidative stress, this study provides specific ranking of acupuncture modalities for hormonal regulation and testosterone reduction in PCOS patients.

Researchers analyzed 92 different trials to see how various acupuncture methods affect symptoms of polycystic ovary syndrome (PCOS). The study looked at several techniques, including electroacupuncture, fire needles, and moxibustion. These methods were compared based on their ability to regulate hormones like FSH and LH, as well as their effectiveness in reducing testosterone levels.

The results showed that different techniques performed differently depending on the goal. For example, electroacupuncture ranked highly for overall efficacy, while specific combinations of needles and moxibustion were more effective at lowering testosterone. The study also looked at how these treatments affected the ratio between LH and FSH hormones.

Because this was a network meta-analysis of existing studies, the results are based on varied research methods. Some acupuncture techniques involved heat or electrical stimulation, which appeared to be effective in some areas. However, because the original trials had different designs, more high-quality, large-scale studies are needed to confirm these findings and determine exactly how these treatments work for patients.

What this means for you:
Different acupuncture methods show varying success in managing PCOS hormones and testosterone levels.

Common questions

What kind of acupuncture is most effective for PCOS?

The study found that different methods had different strengths. Electroacupuncture ranked highly for overall efficacy, while filiform needle combined with moxibustion was very effective at reducing testosterone levels. Other combinations were also shown to help regulate hormones like FSH and LH.

Are there any safety concerns with these acupuncture methods?

The study included data on adverse events for various techniques, such as fire needles and catgut embedment. However, the report did not list any serious adverse events or specific reasons for patients stopping treatment. You should talk to your doctor about which method is safest for you.

How does this research help people with PCOS?

This analysis of 92 trials helps identify which acupuncture techniques might be most useful for specific goals, such as lowering testosterone or balancing the LH to FSH hormone ratio. Because the evidence comes from many different studies, it is best to discuss these options with a healthcare provider.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
BackgroundPolycystic ovary syndrome (PCOS) is a prevalent gynecological disorder that significantly impairs quality of life and reduces patient confidence in treatment. The efficacy of current Western pharmacological therapies is limited. Acupuncture has shown promise in the management of PCOS, but comparative research on different acupuncture modalities remains scarce.MethodsPubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and the Chinese Biomedical Literature Database were comprehensively searched from database inception to 18 August 2024. Two reviewers independently screened studies, extracted data, and assessed the risk of bias in the eligible studies. Network meta-analysis was conducted using STATA 15.1 and R 4.4.1.ResultsNinety-two randomized controlled trials (RCTs) involving 15 acupuncture-based interventions or combinations were included. According to the surface under the cumulative ranking curve (SUCRA) analysis, for total efficacy (TE), electroacupuncture (99.03%), filiform needle + thunder fire moxibustion (74.77%), and filiform needle with electroacupuncture (64.02%) ranked the highest. For follicle-stimulating hormone (FSH) regulation, fire needle (90.99%) ranked first, followed by filiform needle + electroacupuncture (75.29%) and filiform needle + warming needle moxibustion + electroacupuncture (66.76%). For luteinizing hormone (LH) regulation, warming needle moxibustion (86.75%) ranked first, followed by warming needle moxibustion + electroacupuncture (72.76%) and filiform needle alone (69.55%). For testosterone reduction, filiform needle + moxibustion (96.53%) ranked first, followed by catgut embedment in acupoint + moxibustion (85.64%) and electroacupuncture (82.33%). For LH/FSH ratio improvement, catgut embedment in acupoint (77.73%), warming needle moxibustion + electroacupuncture (72.87%), and filiform needle + warming needle moxibustion + electroacupuncture (66.39%) ranked the highest. For adverse events, fire needle (91.69%) ranked highest, followed by Western medicine (83.17%) and catgut embedment in acupoint (64.08%).ConclusionNo statistically significant differences were observed between single and combined acupuncture therapies. However, modalities incorporating electrical, thermal, or sustained stimulation appear to be more effective. Given the methodological limitations of the included studies, high-quality, rigorously designed RCTs are warranted to validate these findings.Systematic review registrationPROSPERO, CRD42024609903.
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