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Endoscopic full-thickness resection resolves abdominal pain in a patient with a gastric diverticulumDoctors Remove Rare Stomach Pocket That Caused 20 Years of Pain

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Key Takeaway
Consider endoscopic full-thickness resection as a potential treatment for medication-refractory gastric diverticula.

This case report describes the management of a 56-year-old woman who experienced postprandial left upper quadrant pain for 20 years. The patient was diagnosed with a gastric diverticulum and had a history of proton pump inhibitor use. The authors report that endoscopic full-thickness resection (EFTR) was performed as an intervention for the condition.

Following the procedure, the patient experienced a resolution of abdominal pain and showed good healing of the resection site at a 1-month follow-up. Histopathological analysis confirmed a false gastric diverticulum and showed an absence of neoplasia. No adverse events or serious complications were reported during the procedure or the follow-up period.

While the case suggests that EFTR is an effective treatment option for small, medication-refractory gastric diverticula, the evidence is limited by the small sample size of a single case. Further studies are required to establish optimal indications and long-term outcomes for this specific surgical technique in patients with gastric diverticula.

How this fits prior evidence

This case report addresses a gap in the management of gastric diverticula. While prior coverage notes that proton pump inhibitor therapy is a first-line treatment for gastroesophageal reflux disease, this case highlights EFTR as a potential intervention for patients with a gastric diverticulum who are refractory to medication.

Imagine eating a meal and feeling a sharp pain in your upper left belly, every single time, for 20 years. That was life for a 56-year-old woman with a gastric diverticulum, a small pouch that bulges out from the stomach wall. Hers was a false diverticulum, meaning it did not contain all the layers of the stomach. Doctors tried proton pump inhibitors, medicines that reduce stomach acid, but the pain did not go away.

So they tried something different: an endoscopic full-thickness resection, or EFTR. This is a procedure where doctors use a flexible tube with a camera and tools to remove the pouch from inside, without major surgery. After the procedure, the woman's abdominal pain resolved. A check-up endoscopy one month later showed the area had healed well. Lab tests confirmed the pouch was not cancerous.

This is a single case report, which means it describes just one person. That is a big limitation. The researchers say more studies are needed to figure out exactly who might benefit from this approach. No side effects or complications were reported in this case, but one case cannot tell us how safe or effective EFTR is for everyone with this condition.

For now, this offers a glimmer of hope for people with small, medication-resistant gastric diverticula. But it is far from proof. If you have ongoing stomach pain, talk to your doctor about what might be causing it and what options are right for you.

What this means for you:
A rare stomach pouch caused 20 years of pain. One procedure removed it, but this is just one case.

Common questions

What is a gastric diverticulum?

A gastric diverticulum is a small pouch that bulges out from the stomach wall. In this case, it was a false diverticulum, meaning it did not contain all the layers of the stomach. It caused the woman to have pain in her upper left belly after eating for 20 years.

What is endoscopic full-thickness resection (EFTR)?

EFTR is a procedure where doctors use a flexible tube with a camera and tools to remove tissue from inside the stomach or digestive tract. It does not require major surgery. In this case, it was used to remove the gastric diverticulum that was causing pain.

Did the woman have any side effects from the procedure?

No side effects or complications were reported in this single case. However, one case cannot tell us how safe this procedure is for everyone. More research is needed to understand the risks for other patients.

Is this treatment right for me?

This was a single case report, so it is too early to say who might benefit most. The researchers say more studies are needed to define the best candidates for EFTR. If you have ongoing stomach pain, talk to your doctor about your options.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
Gastric diverticula are the rarest gastrointestinal diverticula, traditionally managed medically or surgically. We report a case of a long-standing gastric diverticulum with postprandial abdominal pain refractory to acid suppressive therapy for the past year, successfully treated by endoscopic full-thickness resection (EFTR). A 56-year-old woman presented with a 20-year history of postprandial left upper quadrant pain that had initially responded to proton pump inhibitors (PPIs) but became refractory over the past year. Repeated endoscopies revealed a gastric diverticulum with food impaction. She underwent EFTR for resection of the lesion. The postoperative course was uneventful, with no complications, and she recovered well. Postoperative histopathology confirmed a false gastric diverticulum lacking the muscular layer, with no evidence of neoplasia. At one month follow up, her abdominal pain had resolved, and endoscopy showed good healing of the resection site. This case suggests that EFTR is an effective treatment option for small, medication-refractory gastric diverticula. However, further studies are needed to define its optimal indications. Given the potential risk of coexisting neoplasia in false diverticula, more aggressive management and careful histopathological examination may be warranted.
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