B cell and humoral immunity pathways provide potential targets for modulating inflammation in Inflammatory Bowel Disease
B Cell Therapies Show Potential for Inflammatory Bowel Disease
This systematic review evaluates the B cell-humoral immunity regulatory axis in patients with inflammatory bowel disease (IBD). The authors …
New research highlights how targeting B cells and antibody pathways may help manage inflammation in people with inflammatory bowel disease.
Metabolic reprogramming in the tumor microenvironment drives immune evasion and immunotherapy resistance in gastric cancer
How stomach cancer tricks the immune system to survive
This narrative review explores how metabolic crosstalk and nutrient competition within the tumor microenvironment influence immune suppressi…
Stomach cancer cells starve immune cells of nutrients and flood the area with waste, helping the tumor hide from treatment.
Radiomics and spatial omics offer theoretical framework for precision bladder cancer care
New Imaging and Spatial Data Help Map Bladder Cancer
This systematic review synthesizes evidence on radiomics and spatial omics for characterizing the bladder cancer immune microenvironment. It…
Advanced imaging and spatial mapping offer new ways to study the complex environment around bladder cancer tumors.
Dysregulated m6A methylation contributes to hepatic fibrosis and inflammation in radiation-induced liver injury
Radiation exposure causes liver damage through changes in RNA
This narrative review explores the role of m6A modification in radiation-induced liver injury (RILI). The authors synthesize evidence that i…
New research shows how radiation alters a specific chemical mark on cells, potentially leading to serious liver injury.
FDA Approves Zyrtec-d 12 Hour (cetirizine/pseudoephedrine) for Allergy Symptoms
FDA approves Zyrtec-d 12 Hour for allergy and sinus relief.
FDA approved Zyrtec-d 12 Hour (cetirizine HCl/pseudoephedrine HCl) for temporary relief of hay fever or upper respiratory allergy symptoms i…
The FDA approved Zyrtec-d 12 Hour, a nonprescription tablet that combines an antihistamine and a decongestant. It treats symptoms like runny…
FDA Approves Zyrtec Allergy (cetirizine) for Hay Fever and Upper Respiratory Allergy Symptoms
FDA approves new melt-in-mouth allergy drug Zyrtec Allergy.
The FDA approved Zyrtec Allergy (cetirizine) 10 mg orally disintegrating tablets for temporary relief of symptoms due to hay fever or other …
The FDA approved Zyrtec Allergy (cetirizine) 10 mg orally disintegrating tablets for hay fever and allergy symptoms. The tablet melts in the…
Genistein shows potential to attenuate inflammation and reduce disease severity in autoimmune conditions
Genistein may help reduce inflammation in several autoimmune diseases
This mini review synthesizes preclinical evidence on genistein for autoimmune diseases including SLE, RA, and type 1 diabetes. Findings sugg…
A review of genistein shows it could lower disease severity and inflammation for people with conditions like lupus and rheumatoid arthritis.
Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
Single-cell and spatial omics provide detailed mapping of tumor-immune ecosystems in non-small cell lung cancer
New Mapping Tools May Improve Lung Cancer Treatment Planning
This mini review explores how single-cell RNA sequencing, chromatin profiling, and spatial transcriptomics offer superior resolution for ana…
Advanced mapping techniques are helping researchers identify how lung cancer cells adapt and hide from current treatments to help plan bette…
Lipid metabolism disorders drive podocyte injury and extracellular matrix deposition in diabetic kidney disease
Lipid metabolism issues drive damage to kidneys in diabetes
This systematic review examines the role of lipid metabolism in podocyte injury within diabetic kidney disease. The authors synthesize evide…
New research identifies how problems with fat processing in the body lead to specific cell damage in people with diabetic kidney disease.
Adalimumab and its biosimilar IBI303 show distinct response clusters in ankylosing spondylitis
Trial shows two different ways patients respond to adalimumab
This Phase III randomized controlled trial of 438 patients with active ankylosing spondylitis identified two longitudinal response clusters.…
A new study identifies two distinct groups of people with ankylosing spondylitis who react differently to the same treatment.
Genetic variant identification improves polygenic risk prediction for patients with asthma
New Genetic Mapping Improves Prediction of Asthma Risk
Researchers investigated genetic variants associated with asthma in a large cohort of individuals of European ancestry. The analysis identif…
Researchers used deep learning to identify 69 new genetic markers for asthma, improving how doctors can predict risk in people of European a…