Boron neutron capture therapy combined with immunotherapy may enhance anti-tumor response and transform the tumor microenvironment
Novel insights into the clinical translation of BNCT combined with immunotherapy
This narrative review discusses the potential of combining Boron neutron capture therapy (BNCT) with immunotherapy. The authors suggest this…
A narrative review suggests combining Boron neutron capture therapy with immunotherapy may boost anti-tumor responses and change the tumor e…
Immunotherapies beyond rituximab show high response rates in diffuse large B-cell lymphoma
New immunotherapy options offer high response rates for Diffuse Large B-Cell Lymphoma patients
This narrative review surveys immunotherapy options for diffuse large B-cell lymphoma beyond rituximab, including bispecific antibodies, CAR…
New immunotherapy treatments show high response rates for Diffuse Large B-Cell Lymphoma, offering hope beyond the standard 60% success rate …
Probiotics reduce nasal and eye symptom scores in children with allergic rhinitis
Probiotics may help children with allergic rhinitis nasal and eye symptoms
This systematic review and meta-analysis of 1,739 children found that probiotics, prebiotics, or synbiotics significantly reduced nasal and …
A large review found that probiotics, prebiotics, or synbiotics reduced nasal and eye symptoms in children with allergic rhinitis compared t…
TLS manipulation and immunotherapy in pancreatic cancer face significant mechanistic and regulatory uncertainties
Understanding tumor structures could help treat pancreatic cancer
This narrative review examines TLS manipulation and immunotherapy for patients with pancreatic cancer. The authors note that mechanistic und…
Doctors are trying to understand how tumor structures affect pancreatic cancer treatment, but much remains unknown about these complex biolo…
CD38+ NK cells may link disrupted immune tolerance in rheumatoid arthritis and colorectal cancer
Immune cells linked to cancer and arthritis show unusual activity in early review
A narrative review synthesizes evidence on CD38+ NK cells in rheumatoid arthritis and colorectal cancer, finding increased proportions in pe…
A new look at immune cells shows they behave differently in people with rheumatoid arthritis and colorectal cancer. This early review highli…
Prior Exorchis infection blocks S. japonicum in snails: a narrative review
Snail parasite blocks schistosomiasis infection, researchers find
This narrative review examines competitive exclusion in Oncomelania hupensis snails, finding that prior infection with Exorchis sp. can comp…
A parasite in snails may block schistosomiasis, a disease affecting millions worldwide.
Narrative review on KMT2C alterations in gastrointestinal cancers and therapeutic implications
Genetic changes in gut cancers may open new treatment doors for patients
This narrative review synthesizes evidence on KMT2C alterations across gastrointestinal malignancies. It links KMT2C dysfunction to transcri…
A review of genetic changes in gastrointestinal cancers suggests new ways to treat tumors by targeting specific DNA repair weaknesses.
Narrative review explores HNRNPA2B1 as a possible regulator of RNA fate in cancer
HNRNPA2B1 may regulate RNA fate in cancer cells
This narrative review examines HNRNPA2B1 as a possible regulator of RNA fate in cancer. The authors discuss its roles in RNA processing acro…
A narrative review suggests HNRNPA2B1 might act as a regulator for RNA fate modules in cancer, though evidence remains preliminary.
Narrative review on machine learning for immunogenicity risk assessment in preclinical research
AI tools struggle to predict drug immune risks before trials
This narrative review from an EMBL-EBI workshop discusses the application and opportunities for machine learning and artificial intelligence…
Predicting drug immune risks before clinical trials remains impossible due to data gaps and assay differences.
Review of T cell engagers highlights potential for treating solid tumors and small cell lung cancer cases
Review of tarlatamab for solid tumors and small cell lung cancer
This review examines T cell engagers as a promising intervention for solid tumors, specifically small cell lung cancer. Current data suggest…
This review looks at tarlatamab, a T cell engager, for treating solid tumors and small cell lung cancer. It examines how these drugs work.
Systematic review links viral infections to persistent and chronic urticaria in children and adults
Viral infections may trigger hives that last months or turn chronic in some people
This systematic review of 596 participants examined the association between viral infections and infection-associated urticaria. Findings in…
A review of 596 patients found that viral infections can cause hives lasting months or progressing to a chronic condition in some cases.
Narrative review discusses inflammaging and immunosenescence in older adults with colorectal cancer
Inflammaging and immunosenescence may drive colorectal cancer risk in older adults
This narrative review examines the roles of inflammaging and immunosenescence in older adults with colorectal cancer. The authors note that …
A review suggests that aging immune changes might explain colorectal cancer risk in older people, though the science is still developing.