Advanced diagnostic techniques including molecular profiling and AI offer evolving strategies for allergic rhinitis management
New Diagnostic Methods Show Progress in Allergic Rhinitis Care
This systematic review examines the evolution of clinical examination techniques for allergic rhinitis from conventional methods to advanced…
Advanced tools like artificial intelligence and molecular testing are evolving how doctors identify and manage allergic rhinitis symptoms.
Omics technologies identify inflammatory, fibrotic, and metabolic programs in secondary lymphedema for target identification
New data helps identify biological targets for secondary lymphedema
This systematic review evaluates the role of omics technologies in identifying biomarkers and therapeutic targets for secondary lymphedema. …
Researchers are moving beyond simple physical descriptions of lymphedema to find specific biological markers that could lead to better treat…
Existing food security scales lack the ability to capture unique cultural dimensions for immigrant populations
Cultural Food Security Matters for Immigrant and Refugee Communities
This scoping review of 18 studies synthesizes definitions and indicators of cultural food security for immigrants and refugees. The authors …
Standard food security measures often fail to capture the cultural needs of immigrants, highlighting a need for more inclusive community sup…
Integrated biomarker panels provide more complete insights into mechanism-specific therapeutic responses in rheumatoid arthritis
New markers could help predict how rheumatoid arthritis drugs work
This narrative review evaluates conventional and emerging biomarkers for predicting treatment response and resistance in patients with rheum…
Doctors are looking at new biological markers to better predict which treatments will actually work for people with rheumatoid arthritis.
Upstream alarmins IL-33 and TSLP emerge as key targets in T2 asthma pathogenesis
New research identifies key triggers behind Type 2 asthma inflammation
This systematic review synthesizes the complex immune network underlying T2 asthma, highlighting epithelial-derived alarmins IL-33 and TSLP …
Scientists have identified specific early signals that trigger the complex immune response in people with Type 2 asthma.
Zolbetuximab combined with chemotherapy improves progression-free survival and overall survival in CLDN18.2-expressing gastric cancers
New drug shows promise for advanced stomach and esophageal cancer
This systematic review evaluates zolbetuximab in combination with chemotherapy for patients with advanced G/GEJ adenocarcinoma expressing hi…
A new treatment called zolbetuximab may improve survival rates for patients with specific types of advanced stomach and esophageal cancers.
Proposed CTS protocol aims to convert cold tumors to hot and improve immunotherapy response
New Strategy Aims to Turn Cold Tumors Hot for Treatment
This systematic review proposes a phased anti-hallmark Combinations, Timing, and Sequencing (CTS) protocol involving vascular normalization,…
A new strategy aims to change the environment around tumors to make them more responsive to immunotherapy and better respond to treatment.
Succinate accumulation drives inflammatory and immune dysregulation in rheumatoid arthritis through three distinct pathways
Succinate drives inflammation in rheumatoid arthritis, review finds
This systematic review examines the molecular mechanisms of succinate accumulation and its role in rheumatoid arthritis (RA). The authors id…
A new review reveals how succinate, a natural molecule, fuels inflammation in rheumatoid arthritis, pointing to new drug targets.
Immune ecotypes may offer more refined patient stratification for ccRCC than current biomarkers
Immune Ecotypes May Guide Kidney Cancer Treatment
This mini review explores the use of immune ecotypes to identify treatment-responsive profiles in patients with advanced clear cell renal ce…
New review proposes four immune subtypes in kidney cancer that could explain why some patients respond to immunotherapy and others don't.
m6A modification regulates renal tubular epithelial cell fate and inflammatory responses in acute kidney injury
Gene modification may drive kidney injury, review finds
This systematic review examines the role of N6-methyladenosine (m6A) modification in the progression of acute kidney injury. The authors con…
A new review reveals that a chemical modification to RNA, called m6A, plays a key role in acute kidney injury by affecting cell death and in…
Calcium signaling dysregulation drives keratinocyte defects and immune activation in psoriasis
Calcium signaling problems may drive the cycle of psoriasis
This systematic review synthesizes evidence that impaired calcium sensing and SOCE dysfunction in keratinocytes, alongside persistently acti…
New research identifies how faulty calcium signals in skin cells and immune cells could be a key driver of psoriasis symptoms.
Scavenger receptor-guided and cathepsin B-triggered nanodelivery systems enable targeted macrophage remodeling for atherosclerosis and cancer
New nanodelivery systems target macrophages to treat cancer and atherosclerosis
This narrative review explores the use of scavenger receptor-guided and cathepsin B-triggered nanodelivery systems to target macrophages in …
Scientists are developing smart nanocarriers that use specific cellular triggers to deliver medicine directly to diseased cells in the heart…