Combination therapy with 3M-052 and anti-TNFR2 antibody suppressed colon cancer growth in mouse models while enhancing immune response
Early mouse study links antibody combo to slowed colon cancer growth
A preclinical study using colon cancer mouse models found that combining 3M-052 with an anti-TNFR2 antibody significantly suppressed tumor g…
A preclinical mouse study suggests a specific antibody combination may slow colon cancer growth by boosting immune cells.
HLA-DPA1 and HLA-DPB1 expression is downregulated in pediatric asthma with high diagnostic value
New guideline reveals molecular changes in pediatric asthma cells
This guideline presents a multi-level integrated transcriptomic analysis of pediatric asthma. The authors report significantly downregulated…
A new guideline shows specific immune cells in children with asthma are underactive and stressed, offering clues for future treatments.
Erratum published for vaccine recommendations report
What does a vaccine report correction mean for you?
An erratum notice has been published for a report on vaccine recommendations. No study details, population, or findings are provided in this…
A correction notice for a vaccine report simply fixes an error in the published record and does not add new facts or change vaccination reco…
Glycolysis-centered understanding of ovarian cancer may support biomarker-guided combination strategies and improve translational therapeutic design
New review suggests metabolic pathways in ovarian cancer need better tools to treat
This narrative review explores glycolysis-centered understanding of ovarian cancer. The authors suggest this perspective may support biomark…
A fresh look at ovarian cancer metabolism shows current tools are too limited to guide effective combination therapies for patients.
Multispecies animal models often fail to reflect human nasal sinus anatomy and physiology in chronic rhinosinusitis research
Scientists compare different animal models for studying human nose diseases to find better ways to test new treatments
This narrative review examines the efficiency of murine, sheep, and porcine models in representing human phenotypes for chronic rhinosinusit…
Researchers looked at mice, sheep, and pigs to see which ones best match human nose conditions. They found that simple models often fail to …
Prenatal beta-2-adrenergic agonist exposure linked to increased ASD risk with aOR 1.34 preconception
Prenatal asthma drug use linked to higher autism risk in massive study
This systematic review and meta-analysis evaluated neurodevelopmental outcomes in offspring of pregnant women exposed to asthma medications.…
A huge analysis of millions of births found a link between taking asthma inhalers before or during pregnancy and autism in children.
PD-1/PD-L1 inhibitors plus chemotherapy improve survival in advanced endometrial cancer
Immunotherapy combo extends life in advanced endometrial cancer
A meta-analysis of 4,052 patients from RCTs found that adding PD-1/PD-L1 inhibitors to chemotherapy improved overall survival (median 43.7 v…
Adding immunotherapy to chemo boosted survival by over 14 months in advanced endometrial cancer, a new analysis finds.
Follicular T cell subsets and tertiary lymphoid structures may guide immunotherapy in ovarian cancer
New immune targets offer hope for ovarian cancer patients
This narrative review synthesizes evidence on follicular T cell subsets, tertiary lymphoid structures, and other immune features in ovarian …
A review highlights new immune system features that could help doctors predict treatment success and find better ways to fight ovarian cance…
Extracellular vesicle signalling may participate in postoperative neurocognitive disorder progression in older surgical patients
Scientists explore how stress signals might worsen brain recovery after surgery
This review examines extracellular vesicle signalling as a potential mechanism in perioperative neurocognitive disorders among older and vul…
Current evidence suggests multiple factors drive brain issues after surgery, but exactly how stress signals cause lasting problems remains u…
Epstein–Barr virus infection shows higher seropositivity and viral loads in systemic lupus erythematosus patients compared to healthy controls
Epstein-Barr virus linked to lupus in new review of patient data
A mini review highlights that Epstein–Barr virus infection is more prevalent and active in patients with systemic lupus erythematosus than i…
A new review finds that Epstein-Barr virus is more common and active in lupus patients, suggesting a role in the disease.
Tertiary lymphoid structures represent a promising but context-dependent biomarker and potential therapeutic intermediate in breast cancer
Tertiary lymphoid structures may help predict breast cancer outcomes but need clearer definitions
This narrative review discusses the role of tertiary lymphoid structures (TLS) in breast cancer. The authors note that TLS biological and cl…
Tertiary lymphoid structures might predict breast cancer outcomes, yet their meaning varies too much for simple yes or no labels to work wel…
Immune checkpoint inhibitors appear safe in cancer patients with pre-existing sarcoidosis
Most cancer patients with sarcoidosis stay safe on immune checkpoint inhibitor therapy
A meta-analysis examined immune checkpoint inhibitor use in cancer patients with documented pre-existing sarcoidosis. Most patients showed n…
A look at 43 patients shows most do not have a flare when taking immune checkpoint inhibitors, though some do experience a flare.