HMGB1 and LPS interactions provide potential therapeutic targets for inflammation and coagulation in sepsis
New research identifies how specific proteins drive sepsis inflammation
This narrative review explores the mechanistic roles of Lipopolysaccharide (LPS) and High Mobility Group Box 1 (HMGB1) in sepsis. The author…
Scientists have identified a specific interaction between two molecules that triggers severe inflammation and organ failure during sepsis.
Higher systemic immune-inflammation index values are associated with patients diagnosed with rheumatic diseases
New marker shows inflammation levels in rheumatic disease patients
This meta-analysis of 6,903 patients with rheumatic diseases and 6,724 healthy controls found significantly higher systemic immune-inflammat…
A new way to measure immune activity could help doctors better identify and monitor people living with rheumatic diseases.
FDA Approves Children's Zyrtec Hives (cetirizine) for Hives Relief
FDA approves Children's Zyrtec Hives for itching and hives relief.
The FDA approved Children's Zyrtec Hives (cetirizine) for reducing hives and relieving itching due to urticaria. The product is not intended…
The FDA approved Children's Zyrtec Hives (cetirizine) to relieve hives and itching. It is for ages 6 and older. This drug treats symptoms bu…
FDA Approves Tuxarin Er (codeine/chlorpheniramine) for Cough and Upper Respiratory Symptoms
FDA approves new cough medicine Tuxarin Er for adults only.
The FDA approved Tuxarin Er (codeine/chlorpheniramine) for temporary relief of cough and upper respiratory symptoms due to allergy or common…
The FDA approved Tuxarin Er for adults 18 and older to relieve cough and cold symptoms. It combines codeine and chlorpheniramine. This does …
Immune checkpoint inhibitors are associated with acute kidney injury and multi-organ immune-related adverse events
Immune checkpoint inhibitors linked to kidney and heart risks
This narrative review synthesizes evidence from 68 studies involving 15,392 participants regarding the safety of immune checkpoint inhibitor…
New data shows that certain cancer treatments can cause serious side effects like kidney damage and heart inflammation.
Primary and acquired resistance to immune checkpoint inhibitors in NSCLC involves antigen presentation and TME remodeling
Understanding why some lung cancer treatments do not work for every patient
This systematic review synthesizes mechanisms of primary and acquired resistance to PD-1/PD-L1 inhibitors in patients with non-small cell lu…
Doctors are studying why certain immune-boosting drugs fail to stop lung cancer growth. New insights help find better ways to treat patients…
Immune checkpoint inhibitor regimens for colorectal cancer increase risk of endocrine adverse events
Immunotherapy for colon cancer linked to thyroid problems
This network meta-analysis evaluates endocrine toxicity in patients with colorectal cancer treated with immune checkpoint inhibitor (ICI) ba…
New analysis finds immunotherapy for colorectal cancer raises risk of thyroid issues, especially with certain drug combos.
LncRNA signatures predict ICI response and survival across cancers in systematic review
lncRNA Signatures May Help Predict Response to Cancer Treatment
A systematic review of 31 studies found that lncRNA-based signatures consistently stratify cancer patients into groups with significantly di…
Specific genetic markers called lncRNAs may help doctors predict how well cancer patients will respond to immune checkpoint inhibitor treatm…
Macrophage phenotypic plasticity and metabolism influenced by tissue niches contribute to obesity and metabolic disease
Macrophage Metabolism in Obesity Offers New Treatment Clues
This narrative review explores how macrophage metabolism and functional phenotypes are shaped by environmental cues and specific tissue nich…
A review reveals how macrophages change their metabolism in different tissues during obesity, pointing to new ways to treat metabolic diseas…
FDA Approves Ryaltris (olopatadine/mometasone) for Seasonal Allergic Rhinitis
FDA approves new nasal spray Ryaltris for seasonal allergy symptoms
The FDA approved Ryaltris, a combination of olopatadine (H1-receptor inhibitor) and mometasone furoate (corticosteroid), for seasonal allerg…
The FDA approved Ryaltris, a nasal spray that combines an antihistamine and a corticosteroid, for seasonal allergies in adults and teens 12 …
Neoadjuvant chemoimmunotherapy improves pathological response and surgical rates in resectable esophageal squamous cell carcinoma
Immune therapy shows promise for esophageal squamous cell carcinoma
This meta-analysis of randomized controlled trials involving 1070 patients found that neoadjuvant chemoimmunotherapy (NIC) significantly imp…
Adding immune checkpoint inhibitors to chemotherapy before surgery significantly improves tumor response rates in patients with esophageal c…
KRAS G12C inhibitors improve progression-free survival with HR 0.62 in KRASG12C-mutated solid tumors
New drugs show promise for patients with specific tumor mutations
This meta-analysis of 3 RCTs involving 949 patients evaluated KRAS G12C inhibitors for solid tumors. The analysis found a significant improv…
A new class of drugs shows promise in slowing the growth of certain solid tumors for patients with a specific genetic mutation.