Residual (meth)acrylate monomers trigger type IV hypersensitivity in dental settings
Dental materials may cause skin and tissue reactions in patients
This narrative review synthesizes evidence on (meth)acrylate monomers as haptens causing type IV hypersensitivity in patients and dental pro…
Residual chemicals in dental materials can trigger delayed allergic reactions in both patients and dental professionals.
NLRP3 inflammasome modulates immune evasion and chemotherapy sensitivity in gynecological cancers
New research identifies a key driver in gynecological cancer cells
This mini-review examines the role of the NLRP3 inflammasome in ovarian, endometrial, and cervical cancers. It highlights how NLRP3 impacts …
A protein called NLRP3 helps certain cancers hide from the immune system, but it also plays a complex role in how tumors react to treatment.
The osteoimmune-brain axis links systemic inflammation and bone hormones to neurodegenerative pathology
Immune system may link bone health and brain disease
This systematic review examines the role of the osteoimmune-brain axis, where the immune system mediates skeletal and cerebral pathology thr…
A new look at the body's immune system suggests a link between bone health and conditions like Alzheimer's and dementia.
Ferroptosis contributes to endothelial dysfunction, macrophage foam cell death, and necrotic core expansion in atherosclerosis
Ferroptosis May Drive Damage in Arterial Atherosclerosis
This systematic review synthesizes the role of ferroptosis in arterial atherosclerosis by examining iron homeostasis, lipid metabolism, and …
New research identifies how a specific type of cell death called ferroptosis may contribute to the growth of plaque and damage in blood vess…
Metabolic reprogramming of lipid-associated macrophages creates an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
Specific immune cells help pancreatic cancer grow and spread
This narrative review characterizes the role of lipid-associated macrophages (LAMs) and their metabolic pathways in the pancreatic ductal ad…
Researchers identified how specific fat-loving immune cells create a shield that protects pancreatic tumors from the body's natural defenses…
Phenotype-weighted and organ-prioritized frameworks should guide treatment for autoinflammatory diseases despite molecular diagnosis limitations
Molecular diagnosis alone may not guide autoinflammatory disease treatment
This narrative review examines the management of autoinflammatory diseases, including type I interferonopathies and inflammasome-related dis…
A new review finds that knowing the genetic cause of an autoinflammatory disease often doesn't predict which organs will be affected or how …
Immune-mediated loss of HCRT neurons drives sleep-wake circuit instability and brain network reconfiguration in narcolepsy
New research explains how immune attacks cause narcolepsy symptoms
This systematic review synthesizes the pathophysiology of narcolepsy, focusing on how genetic and environmental factors trigger an immune-me…
A new look at narcolepsy reveals how an immune-driven attack on specific brain cells causes sleep issues and sudden muscle weakness.
Necroptosis emerges as pathogenic hub in asthma, linking type 2 inflammation and steroid resistance
Necroptosis may drive severe inflammation in asthma cases
This systematic review posits necroptosis as an active pathogenic hub in asthma, driving type 2 inflammation, a neutrophilic steroid-refract…
New research identifies necroptosis as a potential driver of steroid-resistant inflammation and airway remodeling in patients with asthma.
Pola-R-CHP reduces progression risk 35% in double-expressor DLBCL, but OS unchanged
New Treatment Options Show Promise for Specific Lymphoma Patients
This network meta-analysis of 1,016 treatment-naïve patients with MYC/BCL2 double-expressor DLBCL found that Pola-R-CHP significantly reduce…
A new drug combination may reduce the risk of disease progression in patients with a specific type of lymphoma.
Training programs to teach behavioral mealtime interventions for children with food refusal and selectivity
Parent training helps kids with picky eating, review finds
This systematic review of 49 articles examines training procedures designed to teach parents or caregivers how to implement behavioral mealt…
A review of 49 studies finds training parents in mealtime strategies can help children who refuse food or eat very selectively.
Allergic conjunctivitis pathogenesis and endotypes point toward precision therapy
New insights into allergic conjunctivitis could lead to personalized treatments
This narrative review explores pathophysiological and molecular mechanisms of allergic conjunctivitis, including local and systemic immune r…
A review reveals how genetic and immune factors drive allergic conjunctivitis, paving the way for tailored therapies.
Extracellular vesicles show consistent presence and biological activity across diverse neonatal conditions
Small particles called extracellular vesicles show promise in neonatal health
This systematic review of 43 predominantly observational studies identifies the consistent presence and biological activity of extracellular…
Tiny particles called extracellular vesicles appear consistently in the fluids of newborns, potentially offering new ways to track and manag…