Anti-centromere antibody-positive Sjögren's syndrome profile predicted by serologic and clinical factors
New Tool Predicts Hidden Risk in Sjögren’s Patients
This retrospective observational cohort study developed a predictive model for anti-centromere antibody-positive Sjögren's syndrome in 616 p…
Dry eyes. Dry mouth. Fatigue. For many with Sjögren’s syndrome, these are daily struggles.
HSCT in AK2-Related Reticular Dysgenesis: 85.7% Survival at 10 Years
Rare Immune Disorder: Early Transplant Restores Immunity in Newborns
This retrospective observational cohort study from a single high-consanguinity center evaluated 10 patients with AK2-related reticular dysge…
Early stem cell transplants may save babies with a rare immune disorder, restoring immunity and hearing stability in a small study.
Combined tebentafusp and SBRT showed disease control in a patient with metastatic uveal melanoma
One Woman’s Rare Eye Cancer Spread. Then a New Combo Stopped It Cold
This case report describes a 39-year-old woman with localized uveal melanoma who developed liver and hilar adenopathy metastases.
This story shows how combining a new immune drug with targeted radiation may help the body fight cancer longer, even after it has spread.
Beta-cell stress responses contribute to early Type 1 diabetes development and disease progression
Type 1 Diabetes May Start Inside the Cell, Not Just the Immune System
This perspective and review of human tissue, single cell transcriptomics, and longitudinal cohort studies indicates that beta-cell stress re…
This study shifts the focus of Type 1 diabetes from a pure immune problem to a two-part story where stressed cells play a key role.
Review of combination strategies for digestive system tumors including gastric and colorectal cancer
Unlocking New Ways to Beat Drug Resistance in Digestive Cancers
This review examines theoretical approaches to enhance efficacy in patients with digestive system tumors, including gastric, colorectal, and…
Researchers are finding better ways to combine treatments so drugs keep working longer.
Triple therapy with TACE, TKIs, and ICIs shows survival benefits in unresectable hepatocellular carcinoma
Triple therapy offers a 52% chance of living three years with advanced liver cancer
This retrospective cohort study evaluated 270 patients with unresectable hepatocellular carcinoma receiving first-line triple therapy across…
Patients with advanced liver cancer receiving triple therapy had a 52% chance of surviving three years, offering new hope for those facing d…
Case Report Describes Treatment of Severe Mosquito Bite Allergy and EBV-Associated NK-Cell Lymphoproliferative Disorder
Why a 70-Year-Old Man’s Mosquito Bites Turned Deadly
This case report details the clinical management of a 70-year-old male with severe mosquito bite allergy and EBV-associated NK-cell lymphopr…
A single mosquito bite can sometimes signal a hidden immune problem, especially in older adults.
Systematic review of anti-IL-5 biologics in hypereosinophilic syndrome kidney disease reports low certainty evidence
New Clues Help Doctors Spot Kidney Trouble in Rare Blood Disease
This systematic review with narrative synthesis evaluates anti-IL-5 and IL-5Rα biologics in patients with histologically confirmed hypereosi…
A new review shows kidney issues in rare blood disorders are tricky to diagnose but may respond well to specific drugs.
Narrative review explores TLR7 and TLR9 signaling networks within systemic lupus erythematosus and Sjögren's disease contexts
Why Lupus and Sjögren’s Flares May Start in Your Cells’ “Mailroom”
This narrative review examines the role of TLR7 and TLR9 signaling networks in systemic lupus erythematosus and Sjögren's disease.
Understanding how these immune sensors misfire could lead to more precise treatments that calm flares without shutting down your whole immun…
Anti-CENP-B Antibody Positivity Associated With Clinical Features in Primary Sjögren’s Disease Cohort
Sjögren’s Disease: This Antibody Points to Milder Symptoms
This ambispective cohort study of 1,222 patients with primary Sjögren’s disease evaluated anti-CENP-B antibody positivity and associated cli…
Finding a specific antibody in your blood might mean your Sjögren’s disease is less active than expected.
Good's syndrome patients show reduced IgG, absent B cells, and altered Tfh subsets compared to healthy controls
Why Your Immune System Stops Making Antibodies
This cohort study evaluated three patients with Good's syndrome and twenty healthy controls.
Imagine your body as a fortress under constant attack.
Moxibustion plus montelukast for cough variant asthma with wind cold
Moxibustion plus montelukast improves cough-variant asthma symptoms and lung function
In 94 patients with cough variant asthma of wind cold attacking the lung, a randomized controlled trial compared modified painless wheat-gra…
Adding a painless moxibustion technique to montelukast improved symptoms, lung function, and long-term control in cough-variant asthma tied …