Small bowel metastasis from esophageal squamous cell carcinoma shows male predominance and 6-month median survival
Small bowel spread from esophageal cancer has a short survival window
This systematic review of 23 patients with small bowel metastasis from esophageal squamous cell carcinoma found a strong male predominance (…
Patients with esophageal cancer that spreads to the small bowel often face a short survival window of about 6 months after diagnosis.
E3 ubiquitin ligases regulate DNA repair and promote resistance in gastrointestinal malignancies
E3 Ligases May Help Overcome Drug Resistance in Gastrointestinal Cancers
This systematic review explores the role of E3 ubiquitin ligases in gastrointestinal malignancies. The authors conclude that E3 ligases regu…
New research identifies E3 ligases as key players in how gastrointestinal cancers resist chemotherapy and radiation, offering a potential pa…
Daratumumab improves progression-free survival in patients with cytogenetically high-risk multiple myeloma
Daratumumab shows significant progress for high risk multiple myeloma
This meta-analysis evaluated the impact of daratumumab on progression-free survival in patients with cytogenetically high-risk multiple myel…
A new analysis shows that the drug daratumumab significantly slows the progression of high risk multiple myeloma in patients.
mRNA vaccines reshape tumor microenvironment and induce durable anti-tumor immunity in lung cancer
mRNA Vaccines Show Promise for Lung Cancer Treatment
This systematic review examines the current status and prospects of mRNA vaccines for lung cancer. The authors synthesize evidence that mRNA…
New research explores how mRNA technology can reshape the tumor environment and trigger immune responses to fight lung cancer.
Organ-specific metastatic niches at vascular-immune interfaces shape the fate of disseminated tumor cells
Specific Organ Environments Shape How Cancer Spreads to New Sites
This mini review explores how distinct organ microenvironments, including lung, liver, bone, and brain, influence metastatic progression. Th…
Cancer cells adapt to different parts of the body by interacting with local immune cells and blood vessels in specific areas like the lungs …
Platelet-rich plasma, autologous serum, and cyclosporine A show specific benefits in Sjögren's syndrome dry eye
Topical Eye Treatments Show Different Benefits for Sjögren's Dry Eyes
This systematic review and network meta-analysis evaluated topical ocular therapies for Sjögren's syndrome-related dry eye disease. The anal…
New research identifies specific eye drops and treatments that may help different aspects of dry eyes caused by Sjögren's syndrome.
Plectin knockdown and troglitazone treatment inhibit growth and migration in papillary thyroid carcinoma cell lines
Plectin and Troglitazone Show Promise in Thyroid Cancer
This guideline synthesizes preclinical data regarding plectin (PLEC) as a potential target in papillary thyroid carcinoma. The findings sugg…
Researchers found that plectin is elevated in papillary thyroid cancer and that troglitazone may fight it by targeting plectin.
Metabolic parameters MTV and TLG predict poorer survival in NSCLC patients on immune checkpoint inhibitors
Specific PET scan metrics predict outcomes for lung cancer patients
This systematic review and meta-analysis of 33 studies evaluated baseline [18F] FDG PET/CT metabolic parameters as prognostic indicators for…
Certain measurements from PET scans can help doctors predict how well lung cancer patients will respond to immune checkpoint inhibitor thera…
Perioperative immune checkpoint inhibitors with chemotherapy increase pathological complete response rate by 2.91 RR
Immune Checkpoint Inhibitors Combined With Chemotherapy Improve Cancer Response
This meta-analysis of randomized controlled trials evaluated perioperative immune checkpoint inhibitors combined with chemotherapy for resec…
Adding immune checkpoint inhibitors to chemotherapy may significantly improve response rates for patients with certain types of stomach and …
Artificial intelligence applications in pediatric nutrition show mixed results for dietary assessment and meal planning
Artificial intelligence helps track and predict children's nutrition needs
This mini review examines the role of artificial intelligence in child nutrition, including dietary assessment, malnutrition forecasting, an…
New research looks at how artificial intelligence can help doctors track child nutrition, predict malnutrition, and suggest meals for kids.
FDA Approves Takhzyro (lanadelumab-flyo) for Prophylaxis of Hereditary Angioedema Attacks
FDA approves new drug Takhzyro to prevent swelling attacks in hereditary angioedema.
The FDA approved Takhzyro (lanadelumab-flyo) for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adult and pediatric patien…
The FDA approved Takhzyro to prevent attacks of hereditary angioedema (HAE), a rare genetic condition causing severe swelling. It is for adu…
D-VRd ranks highest for progression-free survival among anti-CD38 regimens in transplant-ineligible multiple myeloma
New data ranks best treatments for transplant-ineligible multiple myeloma
This network meta-analysis of 6 trials involving 3162 patients evaluated various treatment nodes for transplant-ineligible newly diagnosed m…
A large review of 3,162 patients reveals which combinations of drugs work best to keep multiple myeloma from progressing.