Validated instruments measure current disease burden in chronic spontaneous urticaria rather than long term prognosis
New Tools Help Doctors Track Chronic Urticaria and Angioedema
This guideline provides a narrative review of scoring systems and biomarkers for risk stratification in chronic spontaneous urticaria. The r…
New scoring systems and biomarkers help doctors better track disease activity and identify which patients might respond best to specific tre…
Resistance training may increase CD4+ T-cell count in adults living with HIV
Resistance training may improve T-cell counts for people with HIV
This meta-analysis of 13 trials with quantitative data found no significant effect of resistance training on inflammatory biomarkers in adul…
New data suggests that resistance training could help boost T-cell counts in adults living with HIV, though evidence remains limited.
Later-line antibody-drug conjugates show 25.7% objective response rate in advanced small-cell lung cancer
Antibody-drug conjugates show activity in advanced small-cell lung cancer
This systematic review and meta-analysis evaluates later-line monotherapy with antibody-drug conjugates (ADCs) for advanced small-cell lung …
Antibody-drug conjugates show promise for treating advanced small-cell lung cancer, though they are associated with frequent clinical toxici…
TNF-alpha inhibitors are the most frequent biological agents associated with de novo vitiligo development
Biological Therapies Linked to New Vitiligo Cases in Patients
This scoping review of 39 patients identifies a link between biological therapies and de novo vitiligo, most frequently involving TNF-alpha …
Some patients using biological therapies for inflammatory conditions may develop new cases of vitiligo, often appearing within months of sta…
scRNA-seq and AI integration may identify actionable biomarkers and decipher resistance in glioblastoma
AI and Single-Cell Tools May Help Untangle Glioblastoma
This mini-review explores the integration of single-cell RNA sequencing, spatial transcriptomics, and AI-based computational approaches in g…
New review explores how AI and single-cell tools could crack glioblastoma's resistance and guide better immunotherapy.
Intravenous immunoglobulin significantly improves skin involvement and gastrointestinal manifestations in systemic sclerosis patients
Intravenous immunoglobulin shows promise for systemic sclerosis symptoms
This meta-analysis evaluates the efficacy of intravenous immunoglobulin (IVIG) for systemic sclerosis and inflammatory myopathy. The analysi…
New data suggests that intravenous immunoglobulin treatment may improve skin, gut, and muscle issues for people living with systemic scleros…
Macrophage-to-myofibroblast transition drives fibrosis across kidney, heart, lung, liver, and retina
Macrophages May Turn Into Scar-Forming Cells In Organs
This systematic review synthesizes evidence that macrophages can directly differentiate into extracellular matrix-producing myofibroblasts v…
A review finds certain immune cells may transform into scar-forming cells in the kidney, heart, lung, liver, and retina.
Leakage-based imaging is not a reliable surrogate for immune-cell entry in glioblastoma
Leakage in the brain does not mean immune cells entered
This mini review examines the distinction between blood-brain tumor barrier permeability and productive leukocyte access in glioblastoma. Th…
Just because a blood vessel leaks in a brain tumor does not mean immune cells are actually reaching the cancer to fight it.
Balanced human microbiota supports regulatory T-cell responses and barrier integrity in immune-mediated diseases
Healthy Gut Bacteria Help Protect the Body Against Immune System Problems
This narrative review explores the role of the human microbiota in immune-mediated diseases. The authors conclude that a balanced microbiota…
Your gut bacteria play a huge role in keeping your immune system healthy and strong. A balanced gut helps your body fight off germs and stay…
Keratinocyte necroptosis contributes to epidermal barrier compromise in inflammatory skin diseases and acute injuries
Cell death process may play role in inflammatory skin diseases
This mini review examines the role of keratinocyte necroptosis in inflammatory skin diseases and acute epidermal injuries. The authors concl…
A specific type of cell death in the skin might be driving inflammation and barrier damage in various skin conditions.
piRNA expression may serve as a biomarker for inhaled corticosteroid response in children with asthma
Trial shows piRNAs may predict asthma treatment response in children
Researchers investigated the relationship between piRNA expression, vitamin D status, and inhaled corticosteroid response in children with a…
New research identifies specific genetic markers that may help predict how well children with low vitamin D levels respond to asthma medicat…
Depemokimab reduces exacerbation rates in patients with eosinophilic asthma without improving symptom scores
Depemokimab Reduces Asthma Exacerbations in Eosinophilic Asthma Patients
This meta-analysis evaluated the efficacy of depemokimab in patients with eosinophilic asthma compared to placebo. While the intervention si…
A new analysis shows that depemokimab can reduce the number of asthma flare-ups, though it did not significantly improve daily symptom score…