CXCL13 quantification in PBMCs and plasma distinguishes Sézary syndrome from other cutaneous T-cell lymphomas and dermatoses
A simple blood test could spot a rare skin cancer faster
This cohort study analyzed CXCL13 expression in peripheral blood mononuclear cells (PBMCs) and plasma concentrations in patients with suspec…
A simple blood test for a protein called CXCL13 may help doctors catch a rare, aggressive skin cancer that often looks like eczema for years…
Multiomics analysis reveals sustained immune dysregulation in pediatric MIS-C patients compared to healthy controls
Why Some Children Stay Inflamed Months After a Rare COVID Complication
This multiomics study examined plasma and peripheral immune cells from 13 acute and 18 recovered pediatric MIS-C patients alongside 15 healt…
Some children recovering from rare COVID complications carry invisible inflammation for up to three months because their immune systems stay…
Virome and mycobiome roles in female reproductive tract health are increasingly recognized as potential ecosystem modulators
Viruses and Fungi Hold the Key to Vaginal Health
This systematic scoping review examined the impact of the virome and mycobiome on female reproductive tract health compared to a bacteriocen…
Doctors need to look at the whole microbial team, not just the bacteria, to fix vaginal infections.
Network meta-analysis compares endoscopic techniques for sarcoidosis diagnosis
A Better Way to Diagnose Sarcoidosis Could Save Patients Months of Uncertainty
A network meta-analysis of 35 studies in patients with suspected sarcoidosis compared endoscopic tissue sampling techniques.
Getting the right diagnosis for a complex lung condition just got clearer, potentially saving patients from repeated, less effective tests.
Systematic review evaluates Treg depletion and reprogramming strategies for glioblastoma in adults
A New Tactic to Outsmart the Brain’s Most Aggressive Cancer
This systematic review examined interventions targeting regulatory T cells in adults with glioblastoma.
Researchers are designing new weapons that could help a patient’s own immune system finally attack a deadly brain tumor.
Proton radiotherapy linked to lower severe lymphopenia incidence than photon therapy in lung cancer
Proton Therapy May Slash a Dangerous Side Effect in Half for Lung Cancer
A retrospective cohort study of 131 lung cancer patients receiving curative-intent radiotherapy found severe radiation-induced lymphopenia (…
For lung cancer patients, the type of radiation you get—protons versus standard photons—could dramatically change your risk of a serious tre…
Optimal Pathological Response in LACC After Neoadjuvant Chemoimmunotherapy Shows Promising Short-Term Survival
Good news for advanced cervical cancer patients
A retrospective real-world analysis of 89 patients with locally advanced cervical cancer treated with neoadjuvant chemoimmunotherapy and rad…
Women with advanced cervical cancer who respond well to initial treatment show over 90% survival and may avoid harsh follow-up drugs.
Mepolizumab plus FESS improved lung function and symptoms versus mepolizumab alone in severe CRSwNP
When Your Nose and Lungs Are Fighting the Same War
This single randomized controlled trial enrolled 58 patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) with or without a…
A biologic drug improves both sinus and lung symptoms in people with severe nasal polyps, and adding surgery helps the nose more but doesn't…
Early daratumumab or immunomodulatory agents in high-risk smoldering multiple myeloma show uncertain benefits versus observation
Early Drug May Delay Multiple Myeloma
This systematic review evaluated early intervention with monoclonal antibodies, immunomodulatory agents, or alkylating agents versus observa…
Imagine waking up with a headache. You take a pill, and the pain goes away.
Respiratory virus prevalence is higher in acute asthma than stable asthma across children and adults
Your Asthma Flare-Up Might Not Be What You Think
This systematic review and meta-analysis pooled data from 111 studies involving children and adults with asthma.
A major new analysis reveals viruses are found in more than half of all asthma attacks, forcing a rethink of what a positive test really mea…
Biomarkers and functional assays evaluated for shrimp allergy in African American populations in the United States
Why a Shrimp Allergy Test Might Be Wrong—And What to Do Next
This systematic review examined molecular and environmental biomarkers, extract-based IgE testing, component-resolved diagnostics, and funct…
A common shrimp allergy test often gives false positives, especially in certain communities, meaning many people may be avoiding a food they…
Breg-related gene signature predicts survival and immune landscape in head and neck squamous cell carcinoma
Your Immune System Holds a Hidden Clue to Head and Neck Cancer Survival
This cohort study analyzed patients with head and neck squamous cell carcinoma (HNSCC) using bioinformatics data from TCGA and GEO databases…
A new eight-gene test predicts head and neck cancer survival better than standard measures, helping doctors identify which patients might be…