Olezarsen showed no significant difference versus placebo in noncalcified plaque volume change over 12 months in adults with moderate hypertriglyceridemia
New trial shows olezarsen did not reduce plaque volume compared to placebo in adults with high triglycerides
This randomized, placebo-controlled trial enrolled 468 adults with moderate hypertriglyceridemia and followed them for 12 months. The primar…
A study of 468 adults found that taking olezarsen did not lower plaque volume better than taking a dummy pill. Safety was also similar betwe…
Network meta-analysis compares DOACs and VKAs for intracranial hemorrhage risk
Dabigatran may be safest for brain bleeding risk
This network meta-analysis of 127,267 patients with venous thromboembolism or atrial fibrillation found that all DOACs had lower risk of int…
All blood thinners beat warfarin for brain bleed risk, but dabigatran may be the safest choice.
Narrative review outlines QT monitoring protocols for cancer patients
Cancer patients need better heart monitoring during treatment
This narrative review from MD Anderson Cancer Center discusses QT monitoring protocols and cardiac electrophysiology principles for cancer p…
A new review shows why cancer patients need careful heart monitoring to prevent dangerous rhythm problems.
Review of bedside ligation for patent ductus arteriosus in an extremely low birth weight infant
A single case shows bedside ligation works for a tiny newborn with a heart hole
This review and synthesis examines a single case report of bedside ligation for patent ductus arteriosus in an extremely low birth weight in…
A single case report suggests bedside ligation can close a heart hole and help a tiny newborn breathe easier without major surgery.
Systematic review and meta-analysis of drug-coated balloons versus drug-eluting stents in coronary artery disease
Meta-analysis links drug balloons to higher heart risks
This systematic review and meta-analysis evaluated drug-coated balloons (DCB) versus drug-eluting stents (DES) in 8,123 patients with corona…
A review of 8,123 patients found drug-coated balloons for heart arteries may raise risks of repeat procedures and cardiac death compared to …
Meta-analysis finds cerebral embolic protection does not reduce stroke in TAVR patients
New review shows brain protection devices did not lower stroke risk for heart valve patients
This systematic review and meta-analysis of 11,696 patients undergoing transcatheter aortic valve replacement found that cerebral embolic pr…
A large study of over eleven thousand patients found that using special filters during heart valve surgery did not lower the chance of havin…
Cochrane review finds uncertain benefits of drugs for Friedreich ataxia with low-certainty evidence
Cochrane review finds little benefit for drugs treating Friedreich ataxia
This Cochrane systematic review evaluated pharmacological treatments for people with genetically-confirmed Friedreich ataxia. The analysis i…
A major review of eight studies found that most drugs for Friedreich ataxia likely make little difference to key symptoms compared to placeb…
Review synthesizes how nutrition affects brown adipose tissue in neonatal ruminants
Nutrition may boost brown fat to help newborn ruminants survive cold
This narrative review examines brown adipose tissue (BAT) in neonatal ruminants. The authors describe how BAT is abundant at birth and decli…
A review suggests specific nutrients like fatty acids and vitamins could improve brown fat function to help newborn ruminants handle cold st…
OAC monotherapy offers optimal balance for secondary prevention in atrial fibrillation and stroke patients compared to combination strategies
Taking one blood thinner alone works best for heart and stroke patients compared to mixing medicines
A network meta-analysis of 14,104 patients suggests oral anticoagulant monotherapy is the most favorable strategy for secondary prevention i…
Doctors found that using just one blood thinner is safer and more effective than mixing it with other pills. This approach lowers stroke ris…
Active cancer associated with higher mortality in acute coronary syndromes, PCI may mitigate risk
Patients with active cancer face higher death risk during heart attack hospital stays
This systematic review and meta-analysis of 1,154,050 patients with acute coronary syndromes found that active cancer was associated with si…
A large review of over one million patients shows that having active cancer greatly increases the risk of dying during a heart attack. Howev…
Systematic review and meta-analysis compares jailed balloon versus jailed wire techniques for bifurcation PCI
New Heart Stent Method Cuts Dangerous Complication Nearly 70 Percent
This systematic review and meta-analysis evaluated the jailed balloon technique (JBT) versus the jailed wire technique (JWT) in patients und…
• Jailed balloon technique slashes side branch blockage risk during heart stents • Helps patients needing complex artery splitting procedure…
Meta-analysis shows no significant difference between immediate and staged revascularization for STEMI with multivessel disease
Immediate heart procedure shows no major benefit over staged approach for heart attack patients
This systematic review and meta-analysis evaluated patients with ST-elevation myocardial infarction and multivessel disease undergoing immed…
A large review of heart attack patients with multiple blocked arteries found that doing the full procedure right away did not lower the risk…