Transthyretin stabilizers and RNA-silencing therapies attenuate cardiac remodeling in transthyretin amyloid cardiomyopathy
New Therapies May Slow Heart Damage in Amyloid Cardiomyopathy
This meta-analysis of 3646 adults with cardiac amyloidosis found that transthyretin stabilizers and RNA-silencing therapies are associated w…
Specific drug therapies may help stabilize heart structure and slow the progression of damage for adults with transthyretin amyloid cardiomy…
Survivors of pediatric heart failure surgeries face significant neurodevelopmental and neurocognitive difficulties
Heart device kids face thinking issues, review finds
This narrative mini review examines neurodevelopmental and neurocognitive trajectories in pediatric patients following ventricular assist de…
Kids who get heart pumps or transplants often struggle with thinking and learning. A new review highlights the need for better care.
FDA Approves Tryvio (aprocitentan) for Hypertension in Combination with Other Antihypertensives
FDA approves new blood pressure drug Tryvio for hard-to-treat hypertension.
The FDA approved Tryvio (aprocitentan) for the treatment of hypertension in combination with other antihypertensive drugs in adults not adeq…
The FDA has approved Tryvio (aprocitentan) for adults with high blood pressure that is not controlled by other medications. It is used along…
FDA Approves Inpefa (sotagliflozin) for Heart Failure and Type 2 Diabetes with CKD
FDA approves new pill Inpefa to lower heart risks in certain patients.
The FDA approved Inpefa (sotagliflozin) to reduce cardiovascular death, heart failure hospitalizations, and urgent heart failure visits in a…
The FDA has approved Inpefa (sotagliflozin) to reduce the risk of heart-related death, hospitalization for heart failure, and urgent heart f…
Edoxaban patients with CAD/PAD show higher stroke, ACS, and cardiovascular death rates
Patients with heart disease face higher risks on edoxaban
This prospective cohort study of 13,164 patients with atrial fibrillation (AF) receiving edoxaban in routine care found significantly higher…
New data shows that patients with atrial fibrillation and existing heart disease may face higher rates of stroke and bleeding while on edoxa…
DOAC plus calcium-channel blocker co-use raises major bleeding risk 21% in atrial fibrillation
Combining certain heart medications may increase risk of major bleeding
This meta-analysis of 408,276 patients with atrial fibrillation and elevated thromboembolic risk found that co-use of direct oral anticoagul…
Patients with atrial fibrillation taking both a specific blood thinner and a calcium channel blocker may face a higher risk of serious bleed…
No difference in cardioversion success between RBW and BTE waveforms for atrial fibrillation
Trial Shows No Difference Between Two Shock Waveforms for Atrial Fibrillation
This randomized trial of 546 adult patients with symptomatic atrial fibrillation found no significant difference in successful direct curren…
A clinical trial found that two different types of electrical shock waveforms are equally effective at treating atrial fibrillation.
PCSK9 inhibitors significantly reduce LDL-C levels in patients with atherosclerotic cardiovascular disease
PCSK9 inhibitors lower LDL but not stroke risk
This meta-analysis of 63,328 patients evaluated the efficacy and cost-effectiveness of alirocumab, evolocumab, and inclisiran compared to st…
A large meta-analysis finds PCSK9 inhibitors cut LDL and heart attacks, but stroke risk was unchanged. Evolocumab may offer the best value.
Gene, inflammation, and metabolic dysregulation drive pathophysiology in pediatric dilated cardiomyopathy
Gene, Inflammation, Metabolism Link in Child Heart Failure
This systematic review examines the role of the gene-inflammation-metabolism axis in pediatric dilated cardiomyopathy. The authors identify …
A new review links genes, inflammation, and metabolism in pediatric dilated cardiomyopathy, offering a roadmap for targeted treatments.
PCSK9 inhibitors reduce LDL-C by 35.44% in children with heterozygous familial hypercholesterolaemia
PCSK9 inhibitors lower LDL cholesterol in children with high risk
This systematic review and meta-analysis of randomized controlled trials found that PCSK9 inhibitors as add-on therapy significantly reduced…
New data shows PCSK9 inhibitors significantly lower bad cholesterol in children who do not reach health goals on standard medications.
CHAT-AF-S conversational AI protocol aims to improve quality of life in atrial fibrillation
Trial Plans to Test AI Chatbots for Atrial Fibrillation Patients
This randomised controlled trial protocol will enroll 480 adults with atrial fibrillation to test whether a conversational AI self-managemen…
A new clinical trial plans to see if conversational artificial intelligence can improve the quality of life for adults living with atrial fi…
AI-enabled devices with nurse-led screening show good diagnostic accuracy for opportunistic atrial fibrillation detection
AI tools and nurses help find heart rhythm problems early
This mini review explores the use of AI-enabled single-lead ECG and photoplethysmography for atrial fibrillation screening by non-physician …
New screening methods using AI and nurse-led checkups could catch atrial fibrillation sooner to lower stroke risks in community settings.