Preclinical spatial transcriptomics study maps IMAT gene signature in cardiometabolic disease mouse model
Fat inside your muscles may be rewiring your health—here’s how
This primary preclinical research uses spatial transcriptomics to map human intermuscular adipose tissue (IMAT) gene signatures in a mouse m…
Hidden fat inside your muscles may be rewiring your health by changing how they work, offering new hope for treating metabolic disease.
Protocol for coarse-cereal substitution in school meals to prevent obesity in Chinese primary students
Swapping White Rice for Ancient Grains Could Protect Kids From Obesity
This study protocol describes a cluster-randomized pragmatic controlled trial (pRCT) involving 400 Chinese primary school students (grades 3…
Swapping white rice for coarse grains in school lunches is being tested to stop childhood obesity rates from tripling in China.
Narrative review explores CSF1R inhibitor potential in pediatric medulloblastoma precision immunotherapy
The Hidden Reason Children's Brain Tumors Respond So Differently to Treatment
This narrative review examines the role of CSF1R inhibitors as precision immunotherapy for pediatric medulloblastoma subtypes. The authors a…
Each subtype of children's brain tumors has a unique immune fingerprint, meaning matching treatment to that specific environment could drama…
Weight stigmatization increases physiological stress and appetite markers in women with obesity over 120 minutes.
Being Judged for Your Weight Can Change Your Body Chemistry Fast
This randomised feasibility study examined 18 women living with obesity exposed to a weight-stigmatising paradigm versus a non-stigmatising …
Even a brief moment of weight-based judgment may set off a chain of physical stress responses — including hormonal changes that drive hunger…
Cochrane review finds very low-certainty evidence on IGF-1 for ROP in preterm infants.
Premature Babies and Eye Disease: A Hopeful Treatment Hits a Wall
This Cochrane systematic review synthesized evidence from two RCTs on IGF-1 for retinopathy of prematurity in preterm infants. It found no s…
A promising hormone-based treatment for a leading cause of infant blindness has been tested in clinical trials, but the evidence is too thin…
Narrative review discusses lipid levels in normal range regarding metabolic and endocrine disease risk.
Your Cholesterol Is "Normal" — But Is It Really Safe?
This narrative review explores the relationship between blood lipid levels within the normal reference range and the risk of major metabolic…
Even within normal ranges, small shifts in blood fat levels may quietly raise your odds of diabetes, thyroid issues, and other hormonal dise…
Meta-analysis links diabetic retinopathy with anxiety and depression in over 383,000 patients.
Diabetes Eye Disease and Depression Feed Each Other — and Doctors Are Just Catching On
This meta-analysis synthesizes observational data from 383,195 patients with diabetic retinopathy and/or diabetes mellitus to evaluate the a…
Diabetic eye disease and depression trap patients in a two-way cycle where each condition significantly raises the risk of the other.
Inflammatory and metabolic indices associated with microvascular complications in hospitalized type 2 diabetes patients.
Two Blood Markers Could Predict Serious Diabetes Complications Years Earlier
This retrospective cohort study examined 964 hospitalized patients with type 2 diabetes to assess associations between inflammatory and meta…
Two blood scores measuring inflammation and metabolic stress may predict serious diabetes complications years before symptoms appear.
SBSPON gene variant rs2291219 linked to higher T2DM risk in Northwest Indian population
A Hidden Gene May Be Quietly Raising Your Type 2 Diabetes Risk
A case-control candidate gene association study in a Northwest Indian population found SBSPON gene expression was significantly higher in in…
A hidden gene linked to higher type 2 diabetes risk may also be shortening the protective caps on DNA inside immune cells, signaling faster …
Three-parameter online nomogram predicts diabetic retinopathy risk in community-dwelling type 2 diabetes patients.
Three Numbers Could Tell Your Doctor If Your Eyes Are at Risk
This retrospective cohort study evaluated a three-parameter online nomogram using diabetes duration, HbA1c, and high BMI (≥24 kg/m²) to pred…
A free, web-based calculator using only your diabetes duration, blood sugar control, and BMI could help doctors spot who needs an urgent eye…
Efgartigimod showed higher independent walking at week 4 and running at week 12 versus IVIG in GBS patients unable to walk.
A Newer Drug Outperformed the Standard Treatment for a Paralyzing Nerve Disease
This single-center retrospective study evaluated efgartigimod versus intravenous immunoglobulin (IVIG) in 34 Guillain-Barré syndrome patient…
A newer drug helped 100% of paralyzed Guillain-Barré patients walk again in four weeks, outperforming the standard treatment in a recent stu…
Observational MRI study links impaired hypoglycemia awareness to blunted cerebral blood flow responses in type 1 diabetes
Type 1 Diabetes Rewires How the Brain Responds to Low Blood Sugar
This observational study used hyperinsulinemic clamp with arterial spin-labeling MRI to compare cerebral blood flow responses to hypoglycemi…
Type 1 diabetes changes how the brain handles low blood sugar, and those who can't feel the danger show the most severe disruption in brain …