PON1 genetic variants rs2057681 and rs854572 modulate PONase activity and dysmetabolic risk in MASLD
Your Liver's Hidden Genetic Shield
This cohort study of 922 Portuguese individuals from the PREVADIAB2 cohort examined associations between PON1 genetic variants and metabolic…
Your specific DNA pattern for a liver enzyme predicts diabetes and liver scarring risk better than simple blood tests alone.
Stress hyperglycemic ratio shows nonlinear link to stroke in older adults with metabolic syndrome
Does stress-related blood sugar predict stroke risk in older adults with metabolic syndrome?
This prospective cohort study of 60,931 participants aged 60 or older with metabolic syndrome examined whether the stress hyperglycemic rati…
In older adults with metabolic syndrome, stress-related blood sugar spikes show a complex link to ischemic stroke risk, with risk changing d…
Tirzepatide shows greater lean body mass loss than semaglutide in first-episode GLP-1RA users with type 2 diabetes
One Weight-Loss Drug Trims More Muscle Than the Other — Here's Why
An observational study of 670,422 first-episode GLP-1RA users with type 2 diabetes found tirzepatide was associated with greater relative le…
Losing weight with a popular injection drug is not all equal — one drug may chip away at your muscle more than the other, which matters grea…
Review summarizes pre-post trial on black tea kombucha effects in obesity
Small study finds black tea kombucha linked to metabolic changes in adults with obesity
This review examines a pre-post clinical trial of black tea kombucha consumption in adults with and without obesity.
Regular black tea kombucha may shift metabolic markers and inflammation genes in adults with obesity, though larger studies are needed to co…
GLP-1RA use shows sex-specific pancreatitis and hypotension risks in T2D second-line therapy study
Diabetes drugs work differently in women than men
A retrospective cohort study of 5.15 million adults with type 2 diabetes compared second-line therapies.
Diabetes drugs work differently for women than men, revealing distinct safety and effectiveness outcomes in a massive study of 5 million adu…
First-trimester serum retinol quintiles and pregnancy outcomes in a Chinese prospective cohort
High Vitamin A Might Lower Diabetes Risk But Raise C-Section Odds
A prospective cohort of 1,077 singleton pregnancies in China examined first-trimester serum retinol by quintile.
High vitamin A levels early in pregnancy lower diabetes and low birth weight risks but increase the chance of a C-section.
Preprint paired analysis suggests VSG may improve metabolic and renal markers in youth with T2D and obesity
Surgery Stops Kidney Damage in Obese Teens With Diabetes
This preprint paired analysis examined vertical sleeve gastrectomy (VSG) in youth with type 2 diabetes and obesity over 12 months.
This new study shows that weight-loss surgery can actually heal early signs of kidney stress in teenagers by turning off harmful chemical si…
Meta-analysis finds high prevalence of adverse outcomes in African women with hyperglycaemia in pregnancy
High Sugar in Pregnancy Risks C-Section in Africa
A systematic review and meta-analysis of 9,742 women with hyperglycaemia in pregnancy in Africa found high prevalence rates of caesarean sec…
High blood sugar during pregnancy in Africa significantly raises the risk of needing a C-section, threatening both mother and baby.
Orforglipron shows superior HbA1c reduction versus oral semaglutide in adults with type 2 diabetes on metformin
A New Diabetes Pill Takes On Ozempic's Oral Cousin
A phase 3 RCT of 1698 adults with type 2 diabetes inadequately controlled on metformin found that once-daily oral orforglipron (12 mg or 36 …
A new once-daily diabetes pill called orforglipron lowered blood sugar better than oral semaglutide in a major head-to-head trial, but at th…
L-citrulline with HIIT alters specific microRNAs in obese older adults
How 12 Weeks of Hard Exercise Changes the Molecular Machinery of Aging Muscle
A secondary exploratory analysis of a double-blind randomized trial in 68 obese older adults found that 12-week HIIT with L-citrulline suppl…
A 12-week high-intensity interval training program produced measurable molecular changes in older adults' muscles — and a natural supplement…
Single aerobic exercise bout shows mixed effects on glucose and neuronal insulin signaling in obesity
A Single Workout That Talks to Your Brain
A small RCT in 15 sedentary adults with obesity found a single bout of aerobic exercise at 70% VO₂max showed a trend toward lower glucose AU…
One workout session raised insulin signals in brain particles, offering a clue to how exercise may protect against Alzheimer's over time.
Anakinra reduces inflammatory markers in prediabetes but shows no metabolic improvements in RCT
Two anakinra injections changed blood markers in people with prediabetes
A randomized controlled trial in individuals with prediabetes found that two injections of anakinra significantly reduced total leucocyte co…
Two anakinra injections quickly lowered inflammation markers in people with prediabetes, though the drug did not yet improve blood sugar con…