Over 100 agents in development for moderate to severe ulcerative colitis, with early remission data for one class.
Many new ulcerative colitis drugs are in development, with early trial results for one type
A review describes a pipeline of over 100 investigational agents for moderate to severe ulcerative colitis. In early trials, tumor necrosis …
New ulcerative colitis drugs show over 25% remission in early trials, offering hope for the 20% of patients hospitalized within five years o…
Case report describes ischemic proctitis from rectal arteriovenous fistula requiring multiple interventions
When rectal bleeding won't stop, could a hidden blood vessel connection be the cause?
A case report and literature review describes a 61-year-old man with ischemic proctitis caused by a superior rectal arteriovenous fistula. A…
A rare hidden blood vessel connection caused severe rectal bleeding and scarring in a 61-year-old man, eventually requiring surgical removal…
Perspective reviews emerging antifibrotic therapies for metabolic dysfunction-associated steatohepatitis
Could new drugs finally treat the liver scarring of MASH?
A perspective article reviews emerging antifibrotic therapies for metabolic dysfunction-associated steatohepatitis (MASH), including metabol…
New metabolic drugs and direct liver therapies offer fresh hope for reversing the scarring that leads to dangerous cirrhosis in MASH patient…
Biliary complications in pediatric liver transplant recipients with over 20 years of follow-up
How do doctors manage liver transplant complications decades later in children?
A single-center descriptive analysis of 40 pediatric liver transplant recipients with >20 years follow-up found 13 patients developed biliar…
For some children with liver transplants, late bile duct issues may be managed with close monitoring instead of immediate surgery.
Meta-analysis links maternal health, IBD history, and familial factors to increased IBD risk
Study finds link between pregnancy health, family history, and inflammatory bowel disease risk
A systematic review and meta-analysis of 15 observational studies including 6,507 IBD patients found associations between parental/perinatal…
Mothers with poor pregnancy health or IBD raise their children's risk of inflammatory bowel disease, while any family history also increases…
Meta-analysis finds predictive models for post-ERCP pancreatitis show moderate accuracy
Review finds predictive models for pancreatitis after ERCP show moderate accuracy
A systematic review and meta-analysis of 23 studies evaluated predictive models for post-ERCP pancreatitis in patients undergoing the proced…
Computer models predicting pancreatitis risk after ERCP procedures show moderate accuracy but need more testing before doctors can use them …
Narrative review examines neuromodulators and brain-gut therapies for disorders of gut-brain interaction
Can therapy help your gut as much as medication? A review suggests it might.
A narrative review synthesizes literature on treating disorders of gut-brain interaction (DGBI). It reports neuromodulators show modest effi…
For gut-brain disorders, brain-gut behavior therapies like cognitive behavioral therapy can be just as effective as medication while also im…
Phase 1/2a trial tests oral idebenone safety in adults with NASH and fibrosis
Can an oral drug help people with fatty liver disease? Early safety study begins.
A randomized, double-blinded, placebo-controlled, single-center phase 1/2a study enrolled 53 adults with NASH and stage 1-3 fibrosis to asse…
A new oral drug for fatty liver disease has finished its early safety study, with results expected soon to show if it helps stop scarring.
Phase IIb trial of HH-003 injection for chronic HDV infection completes enrollment of 101 patients
Could a new antibody treatment help people with a serious liver infection?
A multicenter, randomized, controlled, open-label Phase IIb study assessed the efficacy and safety of HH-003 injection in subjects with chro…
A new antibody injection helped control a serious liver virus and heal inflammation in patients with chronic hepatitis delta infection.
Phase 1b/2 study of ERAS-007 combinations in advanced GI malignancies completes enrollment of 101 patients
Can a new drug combination help people with advanced colorectal or pancreatic cancer?
A Phase 1b/2 platform study evaluated ERAS-007 in combination with other cancer therapies in patients with advanced gastrointestinal maligna…
A new drug combination tested in advanced colorectal and pancreatic cancer aims to find safe doses and early signs of tumor shrinkage in pat…
Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer
Could a common diabetes drug help people with rectal cancer respond better to treatment?
A Phase 2 trial (n=60) evaluated adding metformin to neoadjuvant radiochemotherapy (capecitabine + 50 Gy radiation) for locally advanced rec…
Adding a common diabetes pill to pre-surgery treatment for rectal cancer may help clear out cancer cells before the operation begins.
Phase 2 trial tests three Vitamin E doses versus placebo in 200 adults with NAFLD
Vitamin E dosing study in 200 adults with fatty liver disease completes trial
A phase 2 randomized controlled trial enrolled 200 adults with NAFLD to compare three doses of Vitamin E (200 IU, 400 IU, 800 IU) with place…
A completed trial on Vitamin E for fatty liver disease has finished, but the results showing if the doses helped or caused harm are not yet …