Adding linaclotide to PEG did not improve bowel prep quality in high-risk colonoscopy patients undergoing screening procedures
Adding Linaclotide to PEG does not improve bowel preparation for colonoscopy
A randomized trial found that adding linaclotide to polyethylene glycol did not significantly improve adequate bowel preparation rates or ad…
A trial found that adding linaclotide to polyethylene glycol did not improve bowel preparation or adenoma detection compared to placebo plus…
CYP7A1 and SLC39A9 variants linked to bile acid levels and cholestasis in Chinese women
Genetic factors linked to bile acid levels in Chinese pregnant women
This genome-wide association study and meta-analysis in 13,357 Chinese pregnant women identified CYP7A1 and SLC39A9 variants significantly a…
Genetic markers found in Chinese pregnant women connect to bile acid levels and pregnancy liver conditions. This preprint study offers new i…
Gut-liver axis models evolve from static co-cultures to microfluidic systems, review finds
New models aim to mimic gut-liver crosstalk in lab
This narrative review surveys gut-liver axis models, from static co-cultures to microfluidic systems. It identifies underexplored areas such…
Scientists are building better lab models to study how the gut and liver talk to each other, but key gaps remain.
Dynamic LSM changes predict liver events in advanced chronic liver disease
Tracking liver stiffness changes predicts liver-related events in chronic disease
A meta-analysis of 24,557 patients found that dynamic changes in liver stiffness measurement (LSM) predict liver-related events (LREs) in co…
A large meta-analysis found that patients whose liver stiffness increases over time face higher risk of liver complications, while those wit…
Macrophage targeting offers new theoretical approaches for treating gastrointestinal motility disorders and constipation
A new look at macrophages offers fresh ideas for treating gut movement disorders
This narrative review highlights the urgent need for studies on macrophages in gastrointestinal motility disorders. Current knowledge lacks …
This review explores how immune cells called macrophages might help treat conditions like constipation and post-surgery gut paralysis.
Oxaliplatin addition to rectal cancer chemoradiation improves tumor regression
Adding oxaliplatin to radiation helps tumor shrink but does not improve long-term survival for high-risk rectal cancer patients
Adding oxaliplatin to capecitabine chemoradiation for high-risk rectal cancer significantly improved tumor regression rates, but did not enh…
Adding oxaliplatin to standard radiation therapy helped tumors shrink more in high-risk rectal cancer patients, yet it did not improve long-…
Large meta-analysis identifies 30 new genetic loci for ankylosing spondylitis risk
Scientists found genetic links to ankylosing spondylitis in large health data groups
This meta-analysis of 7,551 AS cases and 1,258,581 controls from three biobanks identified 30 genome-wide significant loci and 64 causal-can…
A big study looked at DNA from many people to find genes linked to ankylosing spondylitis. It found specific spots in our genes that might h…
Gut microbiota alterations linked to anxiety and depression in inflammatory bowel disease patients
Gut bacteria patterns linked to anxiety and depression in inflammatory bowel disease patients
This systematic review of 1,040 patients with inflammatory bowel disease found associations between gut microbiota characteristics and anxie…
A review of 1,040 patients found gut bacteria patterns linked to anxiety and depression in inflammatory bowel disease.
PFIC null genotype linked to 2.79-fold higher odds of liver transplantation
PFIC null genotype linked to higher liver transplant risk
This meta-analysis of observational studies including 420 PFIC patients found a close association between null genotype and liver transplant…
A meta-analysis of 420 patients found a strong link between a specific genetic variant and the need for liver transplants in progressive fam…
Chemoimmunotherapy improves survival in solid tumors regardless of liver metastasis status
Chemoimmunotherapy helps solid tumor patients, with or without liver metastases
This systematic review and meta-analysis evaluated 25915 patients with solid tumors receiving chemoimmunotherapy versus chemotherapy alone. …
For people with solid tumors, adding immunotherapy to chemo helps survival whether or not cancer has spread to the liver.
Fecal DNA testing improved colorectal cancer screening rates compared to immunochemical testing in primary care
Fecal DNA test boosts colorectal cancer screening rates in community clinics
A pragmatic cluster randomized clinical trial compared mailed fecal immunochemical tests with automated text outreach against mailed fecal D…
A new trial shows that mailing fecal DNA tests with automated text messages increased colorectal cancer screening participation compared to …
FIPS AUC 0.821 outperforms MELD scores for 90-day mortality prediction in TIPS for ascites
New score outperforms MELD for predicting death after TIPS for bleeding
This meta-analysis of 5,180 patients undergoing TIPS for ascites or gastroesophageal bleeding compared MELD-based scores and the FIPS index …
A new scoring system called FIPS may better predict 90-day death risk after TIPS for bleeding than older MELD scores.