IL-1β inhibition may alleviate aortic aneurysm immunopathology, review suggests
Blocking IL-1 beta may help treat aortic aneurysm inflammation
This narrative review examines the role of IL-1β inhibition in aortic aneurysm. The authors argue that targeting IL-1β could alleviate immun…
A review suggests stopping IL-1 beta could calm the immune system damage inside aortic aneurysms, offering a new path for treatment.
Narrative review links gut microbial metabolites to colorectal cancer mechanisms
Gut microbes may help stop colorectal cancer growth through metabolites
This narrative review examines the role of gut microbial metabolites in colorectal cancer. The authors synthesize evidence suggesting these …
A review suggests gut microbial metabolites can either suppress or promote colorectal cancer by affecting cell growth and inflammation.
Narrative review links hidradenitis suppurativa to metabolic dysfunction and systemic inflammation
New review links skin disease to metabolic health in Hidradenitis suppurativa
This narrative review examines the association between hidradenitis suppurativa and metabolic syndrome. The authors argue that increasing ev…
A new review suggests Hidradenitis suppurativa is part of a broader inflammatory state tied to metabolic dysfunction, urging a multidiscipli…
FDA Approves Linzess (linaclotide) for IBS-C, CIC, and Pediatric Functional Constipation
FDA approves Linzess for irritable bowel syndrome and constipation in adults and children.
FDA approved Linzess (linaclotide) for irritable bowel syndrome with constipation in adults and pediatric patients 7 years and older, chroni…
The FDA approved Linzess (linaclotide) for irritable bowel syndrome with constipation in adults and children ages 7 and older, and for chron…
Bayesian network meta-analysis of drugs for pediatric NAFLD steatosis improvement
New analysis shows specific drugs help children with fatty liver disease improve liver health and lower body weight
This Bayesian network meta-analysis evaluated drugs in pediatric NAFLD patients confirmed by ultrasound or biopsy. The review synthesized da…
A large review of 1,582 children found that certain medicines helped reduce liver fat and improve blood markers. Energy-focused drugs were b…
Narrative review explores microbiome-targeting therapies for inflammatory bowel disease patients
New microbial therapies for inflammatory bowel disease show promise
This narrative review examines the potential of targeting the microbial-metabolic axis for patients with inflammatory bowel disease. The aut…
A review explores how targeting the microbial-metabolic axis might help patients with inflammatory bowel disease using treatments like fecal…
FDA Approves Cholbam (cholic acid) for Bile Acid Synthesis Disorders and Peroxisomal Disorders
FDA approves first treatment for rare bile acid disorders.
FDA approved Cholbam (cholic acid) for treatment of bile acid synthesis disorders due to single enzyme defects and as adjunctive treatment f…
The FDA approved Cholbam (cholic acid) for two rare inherited conditions that affect the liver and digestion. This is the first approved the…
Ursodeoxycholic acid reduces ALT and fibrosis in chronic liver disease patients
UDCA Improves Liver Enzymes and Fibrosis in Chronic Liver Disease
This phase IV RCT in 262 patients with chronic liver disease and elevated ALT found that ursodeoxycholic acid 100 mg three times daily for 8…
A phase IV trial found that ursodeoxycholic acid (UDCA) significantly reduced ALT levels and improved fibrosis scores in patients with chron…
Review of chemopreventive strategies for familial adenomatous polyposis including NSAIDs and other agents
Review of chemoprevention options for familial adenomatous polyposis
This review evaluates chemopreventive strategies for familial adenomatous polyposis, including nonsteroidal anti-inflammatory drugs, prostag…
A review examined chemopreventive strategies for familial adenomatous polyposis, including NSAIDs and other agents, though specific results …
Review of dietary patterns and probiotics in swine production provides theoretical basis for microbiome interventions
Diet and gut microbes may help swine health in theory
This review examines dietary patterns and probiotic interventions alongside gut microbiota-derived tryptophan metabolites in swine. The auth…
This review suggests that specific diets and probiotics could improve swine health through gut bacteria changes, offering a theoretical path…
Systematic review shows high fatigue and pruritus prevalence in primary biliary cholangitis patients
Half of liver disease patients battle severe fatigue and itching
This systematic review and meta-analysis evaluated symptom burden in 13178 patients with primary biliary cholangitis. Fatigue affected 51% o…
Over half of patients with primary biliary cholangitis face severe fatigue and itching, yet most never get proper treatment for these sympto…
Pediatric Gut Microbiome Links to Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
Your Child's Gut Health May Protect Against Fatty Liver Disease
Current literature reveals complex associations between the pediatric gut microbiome and metabolic dysfunction-associated steatotic liver di…
• Specific gut bacteria patterns predict fatty liver risk in children • Helps parents of overweight kids with diabetes or obesity • Not read…