Elafibranor shows a broadly reassuring safety profile in patients with primary biliary cholangitis
Elafibranor shows a reassuring safety profile for patients with PBC
This meta-analysis of 274 patients with UDCA-inadequate-responder primary biliary cholangitis evaluated the safety of elafibranor compared t…
New data suggests the medication elafibranor is well tolerated by patients with primary biliary cholangitis who do not respond well to stand…
Higher histologic liver fibrosis stages correlate with increased risk of cirrhosis and hepatic decompensation
Liver Fibrosis Stages Linked to Higher Risk of Liver Failure
This meta-analysis of 32 studies evaluates the association between histologic liver fibrosis stages and clinical outcomes in patients with M…
Higher stages of liver fibrosis are linked to a significantly increased risk of liver failure and death in patients with fatty liver disease…
CT Derived Visceral Fat Area as a Predictor of Anastomotic Leakage in Rectal Cancer
Visceral fat levels may link to higher risk of rectal cancer complications
A meta-analysis of 5,763 patients identifies visceral fat area over 100 cm² as a significant predictor of anastomotic leakage.
A large review of patient data suggests that high levels of internal abdominal fat are linked to a higher risk of complications after rectal…
Evaluating Volumetric FDG-PET Parameters for Identifying Microsatellite Instability in Colorectal Cancer
PET scans help identify specific markers in colorectal cancer
Volumetric metrics like MTV and TLG show superior performance over intensity-based metrics in identifying MSI status in colorectal cancer pa…
New data shows that specific volume measurements on PET scans can help doctors identify key genetic markers in colorectal cancer.
CAD EYE computer-aided assistance did not significantly improve adenoma detection rates in Lynch syndrome patients
AI assistance does not improve adenoma detection in Lynch syndrome
This randomized controlled superiority trial of 757 adults with Lynch syndrome found that CAD EYE computer-aided assistance did not signific…
A clinical trial found that adding computer-aided detection did not improve the identification of polyps during colonoscopies for Lynch synd…
CADe-assisted colonoscopy did not increase adenoma detection rate compared with conventional colonoscopy
Trial Shows Computer-Aided Detection Does Not Improve Polyp Detection
This randomized clinical trial of 827 patients found no significant difference in adenoma detection rate (60.8% vs. 57.7%) between CADe-assi…
A large trial found that computer-aided detection systems did not increase the rate of finding polyps during colonoscopies for colorectal ca…
Resmetirom Improves MASH Resolution and Fibrosis in F2-F3 Patients
Trial shows resmetirom improves liver health in MASH patients
In a post hoc analysis of 917 MASH patients with F2-F3 fibrosis, resmetirom achieved significantly higher MASH resolution and fibrosis impro…
A Phase 3 trial shows that resmetirom may help resolve MASH and improve liver scarring in adults with specific stages of liver disease.
Intersphincteric resection reduces local recurrence and improves five-year survival in lower rectal cancer
Intersphincteric resection shows better outcomes for lower rectal cancer
This meta-analysis of retrospective studies evaluates intersphincteric resection (ISR) compared to abdominoperineal resection (APR) for lowe…
A new analysis shows that intersphincteric resection can lower complication rates and improve survival for patients with lower rectal cancer…
Nonbioartificial liver support reduces 28-day mortality in acute-on-chronic liver failure by 28% compared to standard therapy
Liver Support Device Cuts 28-Day Death Risk in Sickest Patients
This meta-analysis of 1958 patients found that nonbioartificial liver support (NBALS) significantly reduced 28-day mortality compared to sta…
A liver support treatment cut 28-day death risk by 28% in patients with acute-on-chronic liver failure, a meta-analysis finds.
Watch-and-wait after total neoadjuvant therapy shows comparable oncologic outcomes to surgery for rectal cancer
Watch and wait approach shows promise for rectal cancer patients
This meta-analysis compared watch-and-wait protocols against total mesorectal excision for patients with locally advanced rectal cancer foll…
A new look at rectal cancer treatment shows that some patients may avoid permanent bags and surgery after intensive initial therapy.
Placebo Arms Show 13.09 Cirrhosis Events per 100 Person-Years in Fibrotic MASH
Advanced Liver Scarring Risk Increases With Higher MASH Stages
This meta-analysis pooled placebo arms from randomized trials to estimate cirrhosis incidence in fibrotic MASH (F2-F3). Across 586 patients …
Patients with more advanced liver scarring from MASH face a significantly higher risk of developing cirrhosis over time.
Mediterranean diet reduces BMI and triglycerides in patients with NAFLD and MASLD
Mediterranean diet shows modest benefits for fatty liver disease
This meta-analysis of 980 patients with NAFLD/MASLD found that a Mediterranean diet significantly reduced BMI (SMD -0.43) and triglycerides …
A Mediterranean diet can lower body mass index and triglycerides in people with fatty liver disease, though other metabolic markers stayed t…