Immune checkpoint inhibitors in rectal cancer: balancing anti-tumor effects against ICI-associated colorectal injury
Immune drugs for rectal cancer can cause intestinal damage
This systematic review examines immune checkpoint inhibitors (ICIs) in rectal cancer, highlighting robust anti-tumor effects in dMMR/MSI-H t…
New research explores how specific proteins in the gut help manage side effects from immune checkpoint inhibitors used to treat rectal cance…
Traditional Chinese Medicine potentially influences gastrointestinal motility and gut microbiota in Irritable Bowel Syndrome
Traditional Chinese Medicine may help manage Irritable Bowel Syndrome
This narrative review explores the role of Traditional Chinese Medicine (TCM) in managing Irritable Bowel Syndrome by examining mechanisms l…
New research explores how Traditional Chinese Medicine could influence gut health and brain signaling for those with Irritable Bowel Syndrom…
Gut microbiota alpha diversity increases during the first year of life in infants and toddlers
Gut bacteria diversity in infants peaks around 12 months
This systematic review and meta-analysis of 95 studies synthesized data on gut microbiota development from infancy to toddlerhood. The analy…
New data shows that the variety of gut bacteria in babies and toddlers increases significantly during their first year of life.
FABP2 serves as a sensitive biomarker of intestinal mucosal injury in inflammatory bowel disease
FABP2 Protein May Help Identify Inflammatory Bowel Disease Damage
This systematic review examines the role of fatty acid-binding protein 2 (FABP2) in inflammatory bowel disease. The authors conclude that FA…
A new protein called FABP2 shows promise as a sensitive marker for identifying intestinal damage in people with inflammatory bowel disease.
FDA Approves Iqirvo (elafibranor) for Primary Biliary Cholangitis
FDA approves new drug Iqirvo for a rare liver disease.
The FDA has approved Iqirvo (elafibranor) for primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults wi…
The FDA has approved Iqirvo (elafibranor) for adults with primary biliary cholangitis (PBC), a chronic liver disease. It is used when standa…
ALPPS yields fastest liver growth but worse 1-year DFS than PVE in meta-analysis
ALPPS surgery shows faster liver growth for tumor removal
This meta-analysis of 24 retrospective cohort studies (1263 patients) compared ALPPS, PVE, and LVD for liver hypertrophy before major hepate…
A new analysis of over 1,200 patients reveals that the ALPPS technique leads to faster liver growth and higher completion rates for major su…
Dietary quality and precision nutrition may mitigate the vegetarian hepatoprotection paradox in MASLD patients
Dietary Quality Matters More Than Labels for Fatty Liver Health
This narrative review explores how specific dietary components and genetic interactions influence hepatic lipid homeostasis in MASLD. The au…
Not all vegetarian diets are equal. New research suggests that specific ingredients and nutrient balances matter more than just removing mea…
MRI-based radiomics models predict tumor budding grade in rectal cancer with 0.88 AUC
MRI models show promise in predicting rectal cancer growth
This meta-analysis evaluated the diagnostic performance of MRI-based radiomics for predicting tumor budding (TB) grade in patients with rect…
New MRI-based models may help doctors better predict how aggressive a rectal cancer is by analyzing specific patterns in the tumor.
Durvalumab plus tremelimumab median PFS was 5.4 months in HIMALAYA eligible patients
Patients meeting specific criteria live longer with liver cancer treatment
This observational study of 412 patients with unresectable hepatocellular carcinoma found that those meeting HIMALAYA trial eligibility had …
A study of 412 patients shows those meeting certain health criteria lived significantly longer when treated for advanced liver cancer.
CADe improves adenoma detection rate from 44% to 63% in standard-detector endoscopists
Computer tools may help some doctors find more colon polyps
This prospective study of 263 patients compared TXI with CADe against a historical control group using TXI alone. While the primary outcome …
New imaging technology combined with computer detection helps certain doctors find more polyps during colonoscopies, though it adds extra ti…
Thromboembolic events cost 2.5-fold more per event than bleeding after high-risk endoscopy
High Risk Endoscopy Procedures Linked to Bleeding in Patients
This retrospective cohort study of 2,486 adults on DOAC or warfarin undergoing high-risk endoscopy found a 22.9% bleeding rate at 90 days an…
Patients with atrial fibrillation undergoing high-risk endoscopy face significant risks of bleeding and stroke, which can lead to high medic…
Itopride 150 mg once daily matches 50 mg thrice daily in functional dyspepsia
Trial shows once daily itopride works for functional dyspepsia
This Phase 3 randomized trial in 564 participants with functional dyspepsia or chronic gastritis found that itopride hydrochloride 150 mg on…
A new once-daily dose of itopride may offer the same relief for chronic stomach issues as three daily doses, while being easier to manage.