FDA Approves Cholbam (cholic acid) for Bile Acid Synthesis Disorders and Peroxisomal Disorders
FDA approves first treatment for rare bile acid disorders.
FDA approved Cholbam (cholic acid) for treatment of bile acid synthesis disorders due to single enzyme defects and as adjunctive treatment f…
The FDA approved Cholbam (cholic acid) for two rare inherited conditions that affect the liver and digestion. This is the first approved the…
Ursodeoxycholic acid reduces ALT and fibrosis in chronic liver disease patients
UDCA Improves Liver Enzymes and Fibrosis in Chronic Liver Disease
This phase IV RCT in 262 patients with chronic liver disease and elevated ALT found that ursodeoxycholic acid 100 mg three times daily for 8…
A phase IV trial found that ursodeoxycholic acid (UDCA) significantly reduced ALT levels and improved fibrosis scores in patients with chron…
Review of chemopreventive strategies for familial adenomatous polyposis including NSAIDs and other agents
Review of chemoprevention options for familial adenomatous polyposis
This review evaluates chemopreventive strategies for familial adenomatous polyposis, including nonsteroidal anti-inflammatory drugs, prostag…
A review examined chemopreventive strategies for familial adenomatous polyposis, including NSAIDs and other agents, though specific results …
Review of dietary patterns and probiotics in swine production provides theoretical basis for microbiome interventions
Diet and gut microbes may help swine health in theory
This review examines dietary patterns and probiotic interventions alongside gut microbiota-derived tryptophan metabolites in swine. The auth…
This review suggests that specific diets and probiotics could improve swine health through gut bacteria changes, offering a theoretical path…
Systematic review shows high fatigue and pruritus prevalence in primary biliary cholangitis patients
Half of liver disease patients battle severe fatigue and itching
This systematic review and meta-analysis evaluated symptom burden in 13178 patients with primary biliary cholangitis. Fatigue affected 51% o…
Over half of patients with primary biliary cholangitis face severe fatigue and itching, yet most never get proper treatment for these sympto…
Pediatric Gut Microbiome Links to Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
Your Child's Gut Health May Protect Against Fatty Liver Disease
Current literature reveals complex associations between the pediatric gut microbiome and metabolic dysfunction-associated steatotic liver di…
• Specific gut bacteria patterns predict fatty liver risk in children • Helps parents of overweight kids with diabetes or obesity • Not read…
Meta-analysis shows curcumin reduces weight but lacks impact on BMI or waist circumference in metabolic fatty liver disease patients
Curcumin Helps Weight But Not Waist Size In Fatty Liver
A meta-analysis of curcumin supplementation in patients with metabolic-associated fatty liver disease revealed a significant reduction in bo…
Curcumin might help you lose a few pounds but it will not shrink your waist or fix your BMI score
Systematic Review Explores Ubiquitination in Bacterial Infection and Immune Response
Your Body Has a Hidden Weapon Against Superbugs
This systematic review synthesizes evidence on the role of ubiquitination in bacterial infections. It describes how the ubiquitination syste…
Your immune system uses a natural "tagging" process to mark invading bacteria for destruction, and scientists now understand how to make thi…
Review of sphincter-preserving techniques for ultra-low rectal cancer
New surgery keeps bowel control for ultra-low rectal cancer patients
This narrative review synthesizes evidence on six sphincter-preserving techniques for ultra-low rectal cancer. The authors report satisfacto…
A new surgical approach for ultra-low rectal cancer may better preserve bowel control and reduce the need for a permanent colostomy.
Network meta-analysis of phase 2-3 therapies for non-cirrhotic metabolic dysfunction-associated steatohepatitis
New therapies show promise for liver disease without cirrhosis
This network meta-analysis of 12,787 adults with non-cirrhotic metabolic dysfunction-associated steatohepatitis from phase 2-3 trials evalua…
Treatments targeting metabolism and insulin sensitivity helped more people with early liver disease than placebo, based on a large review of…
Narrative review explores plant-derived extracellular vesicles for rheumatoid arthritis
Plant Particles Quiet Joint Fire in Rheumatoid Arthritis Patients
This narrative review summarizes preclinical evidence on plant-derived extracellular vesicles (PDEVs) for rheumatoid arthritis. PDEVs show p…
• Tiny plant particles calm joint swelling and pain in lab tests • Helps RA patients tired of harsh drug side effects • Still years from pha…
Chinese Version of IBS-SSS Validated for Outcome Assessment in IBS Patients
New Chinese Tool Measures Irritable Bowel Syndrome Severity Accurately
This guideline presents a validation study of the Chinese version of the IBS-SSS (IBS-SSS-C) in a Chinese population with IBS. The instrumen…
A new Chinese-language tool now accurately measures the severity of irritable bowel syndrome for millions of patients.