Microbiota-immune-enteric nervous system interactions provide a framework for understanding functional and slow-transit constipation
New Framework Explores Gut Bacteria Links to Chronic Constipation
This narrative review explores the complex interplay between the microbiome, immune system, and enteric nervous system in patients with func…
A new conceptual model explores how gut bacteria, the immune system, and nerves may interact to cause chronic constipation.
Prevention interventions may reduce e-cigarette ever use while cessation-focused efforts likely reduce current adolescent usage
Interventions May Help Reduce E-Cigarette Use in Young People
This systematic review analyzed 10,510 participants across three studies to evaluate interventions for preventing or ceasing e-cigarette use…
Specific programs may help prevent children from starting e-cigarettes or help teenagers who already use them to quit.
Splenic stiffness measurement shows high sensitivity for varices in children with non-cirrhotic portal hypertension
Measuring Splenic Stiffness Helps Identify Dangerous Vein Enlargement in Children
This systematic review and diagnostic test accuracy meta-analysis of 1027 children found that splenic stiffness measurement (SSM) has high s…
New research shows that measuring spleen stiffness can help doctors find dangerous vein growth in children with liver issues.
Upadacitinib 15 mg daily improves pruritus and skin sclerosis in a case of refractory lichen sclerosus
JAK Inhibitor Upadacitinib Shows Promise for Lichen Sclerosus
This case report and brief literature review describes the use of upadacitinib 15 mg daily for a patient with refractory generalized lichen …
A single case report finds upadacitinib may help treat stubborn lichen sclerosus, with no side effects seen over 10 months.
Metabolic and bariatric surgery achieves 70% steatohepatitis remission in patients with MAFLD
Bariatric surgery shows significant improvements for liver disease and diabetes
This meta-analysis of 71,904 patients with biopsy or elastography-confirmed MAFLD found that metabolic and bariatric surgery leads to signif…
Metabolic surgery can help patients with fatty liver disease achieve remission of both liver inflammation and type 2 diabetes.
Endoscopic investigation for iron deficiency anemia reveals 52.0% prevalence of normal upper gastrointestinal findings
Understanding the Common Findings in Endoscopy for Patients with Iron Deficiency
This meta-analysis of 9,807 adults with confirmed iron deficiency anemia (IDA) evaluated the prevalence of gastrointestinal findings during …
Doctors use endoscopy to find the cause of low iron. This study shows what common issues are found during these tests.
Hepatic vein occlusion with portal vein embolization yields 24.5% greater future liver remnant increase
New surgical techniques show larger liver growth before surgery
This meta-analysis of 5,891 patients undergoing 2-stage hepatectomy found that hepatic vein occlusion combined with portal vein embolization…
Combining specific blood vessel techniques can significantly increase the size of a patient's remaining liver before major cancer surgery.
JAK inhibitors are associated with higher hepatitis B virus reactivation rates than IL-12/23 or IL-17 inhibitors
Specific Immune Inhibitors Show Varying Risks for Hepatitis B Reactivation
This meta-analysis of 29 studies evaluated the risk of hepatitis B virus reactivation (HBVr) in patients receiving various immunomodulators.…
New analysis shows that certain immune inhibitors like JAK inhibitors may carry a higher risk of hepatitis B reactivation than other drug cl…
Persistent descending mesocolon increases operative time and conversion rates in colorectal cancer surgery
Persistent mesocolon makes colorectal cancer surgery longer and harder
This meta-analysis of 4255 patients found that persistent descending mesocolon (PDM) is associated with longer operative times, higher intra…
A specific anatomical variation called persistent descending mesocolon can lead to longer surgery times and higher risks of complications fo…
Twenty-two factors across five ecological levels are significantly associated with fear of cancer recurrence
Factors that influence fear of cancer returning for patients
This meta-analysis identifies 22 factors influencing fear of cancer recurrence in patients with colorectal cancer. These factors span innate…
Living with colorectal cancer often comes with a constant fear of it returning, and new research identifies several key factors linked to th…
MELD and MELD-Na demonstrate higher specificity than Maddrey discriminant function for alcoholic hepatitis mortality
New data compares scoring tools for alcoholic hepatitis mortality
This systematic review and diagnostic meta-analysis compared MDF, MELD, and MELD-Na scores for predicting mortality in patients with alcohol…
Doctors use different scoring systems to predict survival in patients with alcoholic hepatitis, but new data shows no major difference betwe…
Immune crosstalk between innate and adaptive compartments drives inflammatory mechanisms in MASLD and MASH progression
Immune system crosstalk drives fatty liver disease progression
This systematic review examines the role of immune system interactions in metabolic dysfunction-associated steatotic liver disease (MASLD) a…
A new review reveals that immune cells talking to each other may be what pushes fatty liver disease toward severe liver damage.