19 G needles provide superior tissue adequacy and histological diagnosis compared to 22 G needles
Thicker Needles May Improve Tissue Quality in Liver Biopsies
This meta-analysis of six studies evaluated needle gauge for endoscopic ultrasound-guided liver biopsy (EUS-LB) in patients with parenchymal…
A meta-analysis suggests that using 19-gauge needles instead of 22-gauge needles can improve tissue adequacy and diagnosis during liver biop…
Multidrug-resistant pathogens are prevalent in cirrhosis with higher rates in lower-middle-income countries
Gram-negative Bacteria and Resistance Patterns in Cirrhosis Patients
This systematic review and proportional meta-analysis of 2781 clinical infections and 381 colonizations in adults with cirrhosis identifies …
A large review of infections in patients with cirrhosis shows that 60% of bacterial isolates are Gram-negative and many show drug resistance…
Local therapies for liver, lung, and locoregional recurrence improve survival in pancreatic ductal adenocarcinoma
Local Treatments May Improve Survival for Patients with Recurring Pancreatic Cancer
This meta-analysis of 22 studies evaluated local therapies versus conventional management for single-site recurrent pancreatic ductal adenoc…
New data suggests that local treatments like surgery can significantly improve survival for patients whose pancreatic cancer has returned.
HBsAg prevalence 9.98% in Cameroon, higher-risk groups 12.70%
New data reveals high rates of Hepatitis B in Cameroon
This meta-analysis of 100 studies estimates HBsAg prevalence at 9.98% in Cameroon, with lower-risk populations at 8.94% and higher-risk at 1…
Nearly 10 percent of people in Cameroon test positive for Hepatitis B, with higher rates found in certain high-risk groups.
Clinical trials for MASLD show limited racial and ethnic diversity despite increasing Hispanic enrollment
Clinical trials for fatty liver disease lack diversity
This meta-analysis of 91 randomized controlled trials evaluates racial and ethnic diversity in MASLD clinical trials. While Hispanic enrollm…
Most fatty liver disease trials underreport ethnicity, and Black patients are only 2.5% of participants, despite the disease's impact.
Prevotella exhibits dual pro-tumorigenic and anti-tumorigenic roles in gastrointestinal cancer progression
Gut Bacteria Prevotella May Both Fuel and Fight Cancer
This narrative review explores the dual roles of Prevotella in gastrointestinal cancer. The authors synthesize evidence that Prevotella inte…
Prevotella bacteria show dual roles in gastrointestinal cancer, with some strains promoting tumors and others potentially protecting through…
Immune markers correlate with clinical outcomes following nucleos(t)ide analogue withdrawal in chronic hepatitis B
Immune Markers May Predict Outcomes After Hepatitis B Treatment
This mini review synthesizes immune correlates of outcome after nucleos(t)ide analogue withdrawal in patients with chronic hepatitis B. Bene…
New research identifies specific immune markers that may help predict how patients respond when stopping nucleoside analogue medications for…
Gut-brain axis dysregulation links Crohn's disease activity with heterogeneous mood improvements from emerging therapies
Newer gut brain therapies show promise for Crohn's disease depression
This narrative review explores the gut-brain axis as a mechanism for depression in patients with Crohn's disease. The authors synthesize evi…
Living with Crohn's disease and depression is a heavy burden. New research explores how targeting the gut brain axis could help manage both …
Skin lesions typically precede spinal arthritis in patients with follicular occlusion triad and spondyloarthritis
Skin issues may signal upcoming spinal arthritis in some patients
This case report and literature review examines the clinical patterns of peripheral and axial spondyloarthritis in patients with follicular …
New data shows that skin lesions often appear years before spinal arthritis begins in patients with specific inflammatory conditions.
Precision glucocorticoid dosing remains investigational; genetic markers not yet clinically actionable
New research explores personalized dosing for steroid medications
This guideline review outlines a precision medicine framework for glucocorticoid therapy in immune-mediated diseases, incorporating pharmaco…
Doctors are looking at how genetic testing and biomarkers can help tailor steroid doses for people with inflammatory diseases.
Infliximab treatment in pediatric IBD is associated with specific microbial shifts rather than uniform diversity recovery
Infliximab Treatment Linked to Specific Gut Bacteria in Children
This systematic review of 242 pediatric patients with inflammatory bowel disease examines the impact of infliximab on the microbiome. The au…
New research shows that children with inflammatory bowel disease may have specific gut bacteria changes when treated with the medication inf…
Pediatric GERD and proton pump inhibitor exposure are associated with reduced microbial diversity
Proton Pump Inhibitors Linked to Changes in Childrens Gut Health
This systematic review of 31 studies examines the impact of gastroesophageal reflux disease (GERD) and proton pump inhibitor (PPI) use on th…
New research suggests that proton pump inhibitors for childhood reflux may lead to less diverse gut bacteria and other changes in the microb…