Reduced Shannon index indicates lower alpha-diversity in the gut microbiota of patients with primary biliary cholangitis
Gut Microbiota Differences Linked to Primary Biliary Cholangitis
This meta-analysis of 1,057 participants found that patients with primary biliary cholangitis have significantly lower Shannon index values …
A large review of patient data shows that people with primary biliary cholangitis have significantly lower gut bacterial diversity than heal…
Balloon-assisted ESD shows comparable outcomes to conventional ESD for colorectal polyps
Balloon-assisted endoscopic submucosal dissection shows shorter procedure time in RCTs
This systematic review and meta-analysis of 1449 patients found that balloon-assisted endoscopic submucosal dissection (BA-ESD) and conventi…
A meta-analysis of 1,449 patients found balloon-assisted endoscopic submucosal dissection had shorter procedure times in randomized trials, …
Sympathovagal imbalance correlates with IBS symptom severity and shows subtype specificity
Irritable bowel syndrome shows specific brain gut signals linked to symptom severity
This review examines neural dynamics in patients with irritable bowel syndrome. The authors synthesize evidence that reduced vagal tone with…
A review found that reduced vagal tone and relative sympathetic hyperactivity correlate with symptom severity in irritable bowel syndrome pa…
Probiotic supplementation may improve salivary buffering and reduce cariogenic bacteria
A review of six studies shows probiotics may help oral and gut health in people
This systematic review of 6 reviews suggests probiotic supplementation may improve salivary buffering capacity and plaque pH, reduce Strepto…
This review looked at six studies on probiotic supplements. Results suggest better saliva function and fewer bad mouth bacteria, though stud…
Narrative review offers a theoretical framework for personalized management of acute upper gastrointestinal bleeding in patients
New framework for personalized care in upper GI bleeding
This narrative review addresses the management of patients with acute upper gastrointestinal bleeding. The authors provide a theoretical fra…
A new review offers a personalized approach to managing acute upper gastrointestinal bleeding, moving beyond one-size-fits-all care.
Adding linaclotide to PEG did not improve bowel prep quality in high-risk colonoscopy patients undergoing screening procedures
Adding Linaclotide to PEG does not improve bowel preparation for colonoscopy
A randomized trial found that adding linaclotide to polyethylene glycol did not significantly improve adequate bowel preparation rates or ad…
A trial found that adding linaclotide to polyethylene glycol did not improve bowel preparation or adenoma detection compared to placebo plus…
CYP7A1 and SLC39A9 variants linked to bile acid levels and cholestasis in Chinese women
Genetic factors linked to bile acid levels in Chinese pregnant women
This genome-wide association study and meta-analysis in 13,357 Chinese pregnant women identified CYP7A1 and SLC39A9 variants significantly a…
Genetic markers found in Chinese pregnant women connect to bile acid levels and pregnancy liver conditions. This preprint study offers new i…
Gut-liver axis models evolve from static co-cultures to microfluidic systems, review finds
New models aim to mimic gut-liver crosstalk in lab
This narrative review surveys gut-liver axis models, from static co-cultures to microfluidic systems. It identifies underexplored areas such…
Scientists are building better lab models to study how the gut and liver talk to each other, but key gaps remain.
Dynamic LSM changes predict liver events in advanced chronic liver disease
Tracking liver stiffness changes predicts liver-related events in chronic disease
A meta-analysis of 24,557 patients found that dynamic changes in liver stiffness measurement (LSM) predict liver-related events (LREs) in co…
A large meta-analysis found that patients whose liver stiffness increases over time face higher risk of liver complications, while those wit…
Macrophage targeting offers new theoretical approaches for treating gastrointestinal motility disorders and constipation
A new look at macrophages offers fresh ideas for treating gut movement disorders
This narrative review highlights the urgent need for studies on macrophages in gastrointestinal motility disorders. Current knowledge lacks …
This review explores how immune cells called macrophages might help treat conditions like constipation and post-surgery gut paralysis.
Oxaliplatin addition to rectal cancer chemoradiation improves tumor regression
Adding oxaliplatin to radiation helps tumor shrink but does not improve long-term survival for high-risk rectal cancer patients
Adding oxaliplatin to capecitabine chemoradiation for high-risk rectal cancer significantly improved tumor regression rates, but did not enh…
Adding oxaliplatin to standard radiation therapy helped tumors shrink more in high-risk rectal cancer patients, yet it did not improve long-…
Large meta-analysis identifies 30 new genetic loci for ankylosing spondylitis risk
Scientists found genetic links to ankylosing spondylitis in large health data groups
This meta-analysis of 7,551 AS cases and 1,258,581 controls from three biobanks identified 30 genome-wide significant loci and 64 causal-can…
A big study looked at DNA from many people to find genes linked to ankylosing spondylitis. It found specific spots in our genes that might h…