Narrative review outlines clinical framework for managing primary Sjögren's disease with interstitial lung disease
New Hope for Sjögren's Patients with Lung Scarring
A narrative review synthesizes evidence on managing primary Sjögren's disease with interstitial lung disease, highlighting a pragmatic clini…
Lung scarring in Sjögren's disease can be deadly, but new strategies targeting specific disease patterns offer a path forward for patients.
Immune Checkpoint Inhibitors Improve Survival and Response Rates in Patients with Hepatocellular Carcinoma Compared to Standard Therapy
New Drug Gives Liver Cancer Patients More Time
This systematic review and meta-analysis evaluated immune checkpoint inhibitors (ICIs) versus standard therapy or placebo in patients with h…
A new drug helps the immune system fight liver cancer, giving patients more time and better survival rates compared to standard treatments.
Network meta-analysis shows image-enhanced endoscopy methods improve adenoma detection rates compared to high-definition white light imaging in colorectal lesion screening.
New Camera Tech Finds More Colon Cancer Clues
This network meta-analysis of randomized controlled trials involving 28,663 participants evaluated image-enhanced endoscopy (IEE) methods ag…
A new camera tech helps doctors spot hidden colon cancer clues that standard scopes often miss during routine checkups.
Surgical resection improves survival and reduces recurrence compared to radiofrequency ablation for small hepatocellular carcinoma
Needle or Knife for the Smallest Liver Cancers?
This systematic review and meta-analysis evaluated 3,551 patients with single hepatocellular carcinoma (HCC) ≤ 2 cm comparing surgical resec…
For very small liver cancers, a new review of 14 studies suggests surgery may give better long-term survival than needle ablation, though th…
Immune checkpoint inhibitor regimens improve survival versus tyrosine kinase inhibitor monotherapies in advanced hepatocellular carcinoma
The Liver Cancer Treatment That Works Better Depending on Your History
This systematic review and meta-analysis of seventeen studies evaluated immune checkpoint inhibitor (ICI)-based regimens versus tyrosine kin…
Immunotherapy beats older drugs for advanced liver cancer, especially when hepatitis B caused the disease, but benefits depend on your liver…
Robotic simultaneous resection for synchronous colorectal cancer and liver metastases shows feasibility and safety in a meta-analysis.
Robots Are Removing Colon Cancer and Liver Tumors in One Operation
This single-arm meta-analysis included 165 patients aged 18 or older with synchronous colorectal cancer and liver metastases. The study eval…
Robotic surgery safely removes colon cancer and liver tumors in one operation, sparing some patients a second major procedure.
Regorafenib plus nivolumab in second-line hepatocellular carcinoma showed safety and survival signals in a Phase IIa trial.
Some Liver Cancer Patients Are Surviving Far Longer on a New Drug Combination
This Phase IIa trial evaluated regorafenib plus nivolumab as an add-on therapy in patients with hepatocellular carcinoma who had progressed …
A combination of regorafenib and nivolumab showed unexpectedly long survival in people with advanced liver cancer who had already exhausted …
Systematic review of pediatric post-COVID-19 condition mechanisms and clinical presentations in children and adolescents.
Why Some Kids Can't Shake the Effects of COVID
This systematic review examines the pediatric post-COVID-19 condition (PPCC) in children and adolescents. The evidence indicates that mechan…
Some kids still feel sick months after mild COVID due to a perfect storm of immune changes, hidden virus, and gut disruption.
Seladelpar shows improved composite endpoint and ALP reduction in PBC with compensated cirrhosis.
New Drug Helps Liver Disease Patients With Cirrhosis
A phase 3 RCT program (RESPONSE and ASSURE studies) in patients with primary biliary cholangitis and compensated cirrhosis found seladelpar …
A new drug lowers liver stress markers in patients with cirrhosis, offering hope where older medicines often failed to stop disease progress…
Quantitative susceptibility mapping shows higher deep gray matter alterations in Wilson's disease compared to healthy controls
New scan findings show brain changes in Wilson's disease patients compared to healthy people
This meta-analysis evaluated quantitative susceptibility mapping (QSM) alterations in deep gray matter among 325 patients with Wilson's dise…
A new scan technique reveals specific brain changes in Wilson's disease patients, showing higher metal buildup in key areas compared to heal…
Systematic review examines immunological analysis of Blau syndrome pathogenesis to define treatment pathways.
The Rare Childhood Condition That Rewrites What We Know About Inflammation
This systematic review evaluated immunological analyses of Blau syndrome pathogenesis in patients with this condition. The primary outcome f…
A rare childhood disease causes inflammation through a completely different pathway than scientists expected, opening new doors for treatmen…
Gastotypes predict Helicobacter pylori infection status in gastric mucosal samples with high accuracy.
New Stomach Map Reveals Four Hidden Types
This cohort study analyzed 566 gastric mucosal samples to identify microbial community types associated with Helicobacter pylori infection s…
New stomach map reveals four distinct bacterial neighborhoods, showing stool tests cannot tell the real story happening inside your stomach …