Systematic review shows high rates of fibrosis and cirrhosis in children with Pi*ZZ alpha-1 antitrypsin deficiency
1 in 4 children with A1AT deficiency develop cirrhosis
This systematic review and meta-analysis examined children with confirmed Pi*ZZ alpha-1 antitrypsin deficiency to assess liver outcomes.
New analysis finds 41% of children with A1AT deficiency have liver fibrosis and 17% have cirrhosis.
PPAR Agonists Reduce Pruritus in PBC: Meta-Analysis of 660 Patients
New drugs ease itch for patients whose current treatment fails
This systematic review and meta-analysis of 660 patients with primary biliary cholangitis and inadequate response to UDCA found that PPAR ag…
A review of six hundred sixty patients found new medicines significantly reduced itch scores in people with primary biliary cholangitis who …
Narrative review of traditional Chinese medicine for pancreatitis management
Traditional Chinese Medicine May Help Treat Pancreatitis
This narrative review examines the use of traditional Chinese medicine in patients with pancreatitis.
New research suggests Traditional Chinese Medicine could help treat pancreatitis by fixing gut issues and calming inflammation.
Early magnesium sulphate catharsis reduces severe acute pancreatitis and mortality in high-risk patients
Early Magnesium Sulfate Treatment May Stop Pancreatitis From Turning Deadly
This clinical retrospective cohort study evaluated 850 patients with acute pancreatitis at high risk of systemic complications. Early magnes…
Early magnesium sulfate treatment may prevent severe pancreatitis and save lives, a large new study suggests.
Sequential SBRT, pembrolizumab, and resection in oligometastatic colorectal cancer shows 60% 1-year RFS
Phase Ib trial shows promising signs for colorectal cancer treatment
This Phase Ib clinical trial evaluated sequential stereotactic body radiotherapy, pembrolizumab, and resection in 15 patients with oligometa…
A Phase Ib trial found that a specific combination therapy helped 60% of patients stay free from cancer recurrence for one year.
Single 6 mg erdafitinib dose shows similar pharmacokinetics in mild or moderate hepatic impairment versus healthy controls
Single dose of erdafitinib showed no dose changes needed for mild or moderate liver issues
This Phase 1 open-label single-dose study evaluated pharmacokinetics of erdafitinib in 26 participants with hepatic impairment versus health…
A single dose of erdafitinib worked well in people with mild or moderate liver problems, showing no need for dose adjustments.
Narrative review of oxidative stress and antioxidant defense in periodontitis and peri-implantitis
Oxidative stress may drive gum disease and bone loss
This narrative review examines the role of oxidative stress and antioxidant defense systems in periodontitis and peri-implantitis.
New evidence suggests that an imbalance in your body's antioxidant defenses could play a major role in how gum disease progresses.
Multi-omics profiling identifies molecular associations in recurrent pregnancy loss
Multi-omics profiling reveals new links to recurrent pregnancy loss
This review examines the role of multi-omics profiling, including genomics, proteomics, and transcriptomics, in understanding recurrent preg…
New research into complex biological layers shows how genetic and immune patterns may be linked to recurrent pregnancy loss.
Probiotic co-administration with berotralstat improves GI tolerability in HAE patients
Probiotics may help manage side effects of HAE treatment
This pilot case series from six Italian centers evaluated probiotic co-administration with berotralstat in 25 adolescents and adults with he…
New early treatment steps for hereditary angioedema might reduce monthly attacks while keeping stomach issues to a minimum.
Retrospective review suggests preoperative data predicts skeletal muscle loss in gastric cancer patients
Early scans predict muscle loss in gastric cancer patients after surgery
This retrospective cohort study review evaluates a model using routinely available preoperative and early postoperative clinical data to pre…
A new model using routine early data can predict dangerous muscle loss in gastric cancer patients, helping doctors plan better care sooner.
Meta-analysis shows reduced oral microbial Shannon diversity in Crohn's disease versus controls
Oral bacteria shifts could reveal Crohn's disease risk
This meta-analysis reviews data from multiple cohorts involving 1,136 IBD patients and 759 controls.
A new study links distinct mouth bacteria changes to higher gut inflammation levels in Crohn's disease patients.
Narrative review examines links between periodontitis and systemic disorders without claiming causation
Oral inflammation may link to systemic disorders, but evidence is not definitive
This narrative review explores the relationship between oral inflammatory diseases, particularly periodontitis, and various systemic disorde…
A narrative review suggests oral inflammatory diseases like periodontitis are associated with systemic disorders, though the evidence is not…