Meta-analysis identifies 3,207 novel DNA methylation sites linked to smoking
New DNA markers reveal how smoking changes your genes across many backgrounds
This meta-analysis of 45,460 individuals from the Million Veteran Program identified 3,207 novel probe-smoking associations in DNA methylati…
A massive new study shows smoking alters your DNA in thousands of ways, but these changes are not yet tools for doctors to use.
Multi-ancestral GWAS identifies 152 RA loci with improved polygenic risk scores for AFR and AMR populations
New genetic clues for rheumatoid arthritis found in diverse veteran populations
This cohort study utilized the Million Veteran Program (MVP) to perform multi-ancestral GWAS with multimodal automated phenotyping for rheum…
Scientists identified new genetic markers for rheumatoid arthritis in diverse groups, improving risk prediction especially for African Ameri…
Geneticist involvement correlates with higher testing uptake and diagnostic yield in perinatal demise cases
Geneticist Involvement Linked to Better Outcomes in Perinatal Demise Cases
This cohort study of 111 perinatal demise cases observed that geneticist involvement was associated with significant increases in testing up…
A cohort study of 111 cases found that involving a geneticist increased testing uptake, diagnostic yield, and patient education while reduci…
Review of Swedish SCAD patients notes modest actionable variant yield in exome sequencing data
SCAD Heart Attacks in Women Often Start With Rare Genes
This observational review synthesizes data from 201 Swedish patients with spontaneous coronary artery dissection (SCAD) within the SweSCAD n…
Nearly 60% of women with SCAD heart attacks carry rare gene variants linked to vessel strength, reshaping how doctors view this condition.
Observational Study Links Latitude and Genetics to Seasonal Affective Disorder Risk in Adults
Winter Blues Tied to Genes and Where You Live
This primary research article analyzes data from 12,460 adults in the Australian Genetics of Depression Study.
Where you live and the genes you carry may shape how much winter drags down your mood — and it’s not just about sunlight.
Commentary on CalPred calibration performance versus PredInterval in trait prediction
Better Risk Scores Need Honest Uncertainty Ranges
This commentary reviews the performance of CalPred for calibration of prediction intervals, contrasting it with PredInterval.
Imagine getting a weather forecast that says there is a 90% chance of rain.
Narrative review proposes framework for TWAS signature-matching in drug prioritization
New method finds better drug targets using your DNA data
This narrative review and framework proposal examines the TWAS signature-matching approach with varying parameters, including TWAS method, e…
A new gene-based method can point doctors to better drugs, but the right settings are critical for accuracy.
Pharmacogenomic adherence low in paediatric cancer despite actionable recommendations
Doctors Often Ignore Genetic Test Results for Kids with Cancer
This cohort analysis within the MARVEL-PIC RCT assessed clinician adherence to pharmacogenomic recommendations for 216 children with cancer.
Even when genetic tests tell doctors exactly how to adjust a child’s cancer medication, they often don’t listen—and that puts kids at risk.
Review of multi-omics technologies supporting immune checkpoint inhibitor use in cancer patients
New Data Helps Doctors Pick Better Cancer Treatments
This review examines the application of multi-omics technologies within cancer patients treated with immune checkpoint inhibitors.
Using many types of medical data helps doctors choose the right cancer drugs for each person.
Polygenic risk score enrichment reduces sample size needs for coronary artery disease and inflammatory bowel disease trials
Smarter trial designs could cut study sizes by 60% for heart disease
This in silico observational cohort study used UK Biobank data to model trial designs enriched for polygenic risk.
Using genetic risk scores to pick high-risk volunteers could shrink trial sizes by 60% for heart disease and 78% for IBD, speeding up resear…
Narrative review explores conceptual frameworks across RNA worlds
RNA Is Rewriting the Rules of Life—From Ancient Earth to Modern Medicine
This narrative review discusses conceptual frameworks across RNA worlds.
This review reveals how the same molecule that may have started life on Earth is now being engineered to fight disease.
CDK1, B3GNT7, S100A9, and MMP9 Expression Associated with Thyroid Cancer Prognosis
Immune Genes Could Predict Thyroid Cancer Outcomes Better
This retrospective cohort study analyzed 180 thyroid cancer patients to evaluate gene expression and immune infiltration.
A new tool uses immune markers to spot high-risk thyroid cancer cases earlier.