Scoping review examines imatinib gonadotoxicity in males with chronic myeloid leukemia or gastrointestinal stromal tumors
Young Men's Fertility at Risk with Common Cancer Drug Imatinib
This scoping review synthesizes evidence on imatinib effects in males with chronic myeloid leukemia or gastrointestinal stromal tumors. Twen…
• Imatinib harms sperm production more in younger men permanently • Helps doctors counsel teens and young adults before treatment • Not a tr…
FDA Approves Inqovi (decitabine/cedazuridine) for Myelodysplastic Syndromes
FDA approves new oral drug Inqovi for certain blood cancers.
FDA approved Inqovi (decitabine 35 mg/cedazuridine 100 mg) for adults with MDS, including CMML and intermediate-1, intermediate-2, and high-…
The FDA approved Inqovi, a pill that combines two drugs, for adults with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia…
Network meta-analysis of 107 RCTs on blood-invigorating Chinese herbal medicines for endometriosis
Chinese herbal medicines plus standard care help treat endometriosis better than standard care alone
This network meta-analysis synthesizes data from 107 RCTs evaluating blood-invigorating and stasis-resolving Chinese herbal medicines plus c…
A review of many studies shows adding specific Chinese herbs to standard treatment helps more women with endometriosis. Patients felt less p…
Delphi guideline on Para athletics talent identification and development strategies
Experts agree on best ways to find and train talented para athletes through surveys
This Delphi survey guideline synthesizes expert consensus on best practices for talent identification and development in Para athletics. The…
Twenty-three experts reviewed talent identification methods for para athletics. They agreed on using performance tests, personalized plans, …
Narrative Review Explores Immune Checkpoint Inhibition in Pediatric Medulloblastoma
New immune targets offer hope for children with recurrent brain tumors
This narrative review discusses the potential of immune checkpoint inhibition via direct antibody targeting in pediatric medulloblastoma. Th…
A new generation of immune drugs is being tested to help children whose brain tumors have returned after standard treatment
Meta-analysis links HLA alleles and ADAMTS13 variants to thrombotic thrombocytopenic purpura risk
Your Genes Could Predict Your Risk of This Rare Blood Disorder
This systematic review and meta-analysis synthesizes genetic associations in immune and congenital thrombotic thrombocytopenic purpura. HLA-…
Your DNA may hold clues to whether you will develop a rare but dangerous blood clotting condition, and new research is finally mapping those…
Meta-analysis finds no clear benefit of adding nutrition to BFR training for strength or hypertrophy in healthy adults
Adding nutrition to blood flow restriction training helps healthy adults build muscle and last longer during workouts without extra strength gains
This systematic review and meta-analysis evaluated BFR training combined with nutritional interventions versus BFR alone in healthy adults. …
A review of healthy adults found that adding nutrition to blood flow restriction training improved muscle endurance and growth, but did not …
Genetic variants in ABCB1 and ABCG2 raise imatinib trough levels in CML patients
Genes affect imatinib drug levels in chronic myeloid leukemia patients
A meta-analysis shows specific ABCB1 and ABCG2 polymorphisms significantly increase imatinib plasma trough concentrations, supporting pharma…
Certain gene variants can raise imatinib levels in leukemia patients. This may help doctors personalize treatment for better results.
Systematic review and meta-analysis of interim FDG PET in large B-cell lymphoma patients
Early PET scans help doctors predict how well large B-cell lymphoma treatments will work for patients
This systematic review and meta-analysis evaluated the utility of interim FDG PET (iPET) in 44 eligible studies involving large B-cell lymph…
A review of many studies shows that early PET scans can tell doctors if cancer treatment is working. This helps them decide the best next st…
FDA Approves Epysqli (eculizumab-sbja) for PNH, aHUS, and gMG
FDA approves new drug Epysqli for three rare blood and nerve conditions.
The FDA approved Epysqli (eculizumab-sbja) for paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and gen…
The FDA approved Epysqli (eculizumab-sbja) for paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and generalized myas…
Systematic review and meta-analysis finds high prevalence of ocular manifestations in leukemia patients
Leukemia patients face eye risks that doctors must spot early now
This systematic review and meta-analysis of 1016 patients with leukemia found a 42% prevalence of overall ocular manifestations.
New data shows almost half of leukemia patients have eye issues, so regular eye checks are essential for better care
Fixed-duration subcutaneous mosunetuzumab shows favorable efficacy and safety versus IV in relapsed follicular lymphoma
Subcutaneous Mosunetuzumab Shows Promise for Follicular Lymphoma Patients
This Phase 2 primary analysis evaluated fixed-duration subcutaneous mosunetuzumab versus mosunetuzumab IV in patients with relapsed or refra…
A Phase 2 trial found subcutaneous mosunetuzumab had lower rates of severe side effects than the IV version for treating follicular lymphoma…