Narrative Review Explores Immune Checkpoint Inhibition in Pediatric Medulloblastoma
New immune targets offer hope for children with recurrent brain tumors
This narrative review discusses the potential of immune checkpoint inhibition via direct antibody targeting in pediatric medulloblastoma. Th…
A new generation of immune drugs is being tested to help children whose brain tumors have returned after standard treatment
Meta-analysis links HLA alleles and ADAMTS13 variants to thrombotic thrombocytopenic purpura risk
Your Genes Could Predict Your Risk of This Rare Blood Disorder
This systematic review and meta-analysis synthesizes genetic associations in immune and congenital thrombotic thrombocytopenic purpura. HLA-…
Your DNA may hold clues to whether you will develop a rare but dangerous blood clotting condition, and new research is finally mapping those…
Meta-analysis finds no clear benefit of adding nutrition to BFR training for strength or hypertrophy in healthy adults
Adding nutrition to blood flow restriction training helps healthy adults build muscle and last longer during workouts without extra strength gains
This systematic review and meta-analysis evaluated BFR training combined with nutritional interventions versus BFR alone in healthy adults. …
A review of healthy adults found that adding nutrition to blood flow restriction training improved muscle endurance and growth, but did not …
Genetic variants in ABCB1 and ABCG2 raise imatinib trough levels in CML patients
Genes affect imatinib drug levels in chronic myeloid leukemia patients
A meta-analysis shows specific ABCB1 and ABCG2 polymorphisms significantly increase imatinib plasma trough concentrations, supporting pharma…
Certain gene variants can raise imatinib levels in leukemia patients. This may help doctors personalize treatment for better results.
Systematic review and meta-analysis of interim FDG PET in large B-cell lymphoma patients
Early PET scans help doctors predict how well large B-cell lymphoma treatments will work for patients
This systematic review and meta-analysis evaluated the utility of interim FDG PET (iPET) in 44 eligible studies involving large B-cell lymph…
A review of many studies shows that early PET scans can tell doctors if cancer treatment is working. This helps them decide the best next st…
FDA Approves Epysqli (eculizumab-sbja) for PNH, aHUS, and gMG
FDA approves new drug Epysqli for three rare blood and nerve conditions.
The FDA approved Epysqli (eculizumab-sbja) for paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and gen…
The FDA approved Epysqli (eculizumab-sbja) for paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and generalized myas…
Systematic review and meta-analysis finds high prevalence of ocular manifestations in leukemia patients
Leukemia patients face eye risks that doctors must spot early now
This systematic review and meta-analysis of 1016 patients with leukemia found a 42% prevalence of overall ocular manifestations.
New data shows almost half of leukemia patients have eye issues, so regular eye checks are essential for better care
Fixed-duration subcutaneous mosunetuzumab shows favorable efficacy and safety versus IV in relapsed follicular lymphoma
Subcutaneous Mosunetuzumab Shows Promise for Follicular Lymphoma Patients
This Phase 2 primary analysis evaluated fixed-duration subcutaneous mosunetuzumab versus mosunetuzumab IV in patients with relapsed or refra…
A Phase 2 trial found subcutaneous mosunetuzumab had lower rates of severe side effects than the IV version for treating follicular lymphoma…
Meta-analysis links perinatal factors to childhood acute leukemia risk
Perinatal factors linked to higher leukemia risk in children
This systematic review and meta-analysis of 85 studies examined perinatal factors and childhood acute leukemia risk.
A large analysis of 85 studies finds links between birth weight, maternal history, and cesarean sections with childhood leukemia risk.
Meta-analysis links maternal infection in pregnancy to childhood ALL risk
Maternal Infections During Pregnancy Linked to Higher Risk of Childhood Leukemia
This systematic review and meta-analysis of 26 studies found a modest association between maternal infection during pregnancy and childhood …
A large review of 26 studies found that maternal infections during pregnancy are associated with an increased risk of acute lymphoblastic le…
Machine learning predicts recreational therapy engagement in veterans
Veterans at Risk of Isolation Can Be Found Early
This cross-sectional study of 57 veterans used machine learning to predict recreational therapy engagement.
New computer models can spot veterans at risk of isolation so staff can help them join fun activities sooner.
Systematic Review Links Lysosomal Pathways to Autoimmune Kidney Disease Progression
Lysosomal pathways may control autoimmune kidney disease progression
This systematic review synthesizes evidence that lysosomal functions act as checkpoints in autoimmune kidney diseases like lupus nephritis a…
New evidence suggests that targeting lysosomal functions could offer a new way to manage serious autoimmune kidney diseases.