Polymyxin B haemoadsorption associated with lower mortality in endotoxic septic shock patients
Polymyxin B blood filter cuts death risk in severe septic shock
This phase 3 trial examined polymyxin B haemoadsorption versus standard care in adults with endotoxic septic shock and multiorgan dysfunctio…
A blood filter that removes toxins may cut deaths in adults with severe septic shock, new trial results suggest.
Meta-analysis shows association between adequate antimicrobial therapy and reduced hospital length of stay
Right Antibiotic Choice Cuts Hospital Stay by Nearly Two Weeks
This meta-analysis of 4158 adult hospitalised patients examines the relationship between adequate empirical antibiotic therapy and clinical …
Choosing the right antibiotic from the start can cut a hospital stay by nearly two weeks for adults with serious infections.
Network meta-analysis compares biologics and targeted drugs for systemic lupus erythematosus efficacy and safety
New Lupus Treatments Show Stronger Results With Fewer Side Effects
This systematic review and network meta-analysis of 17,121 patients with systemic lupus erythematosus compared biologics and targeted small …
Certain new lupus drugs help more people feel better with fewer flare-ups, especially those struggling with rashes or joint pain that older …
Dental antibiotic prophylaxis does not reduce periprosthetic joint infection risk in total joint arthroplasty patients
Routine dental antibiotics do not lower infection risk for joint replacement patients
This systematic review and meta-analysis evaluated 157466 adult patients who had total joint arthroplasty undergoing dental procedures.
A massive review of over 157,000 patients found that taking antibiotics before dental work does not reduce infection risk for those with joi…
Dual antibiotic-loaded bone cement reduces surgical site infection risk in cemented hip arthroplasty patients compared to single cement
Dual antibiotic cement cuts infection risk for hip surgery patients
This systematic review and meta-analysis evaluated dual antibiotic-loaded bone cement versus single antibiotic-loaded bone cement in patient…
A large analysis shows dual antibiotic-loaded bone cement significantly lowers surgical site infection risk compared to single antibiotic ve…
Multicomponent psychosocial interventions improve antiretroviral therapy adherence in people with HIV
Multicomponent support boosts HIV medicine taking for people living with the virus
This systematic review and network meta-analysis evaluated psychosocial interventions for people with HIV.
A large review found that multicomponent psychosocial interventions significantly improved antiretroviral therapy adherence in people with H…
Tenofovir Disoproxil Fumarate in Maternal ART Linked to Modest Creatinine Decline in HIV-Positive Women
Women on TDF-based HIV meds showed kidney changes compared to infant-only treatment
This randomized trial compared tenofovir disoproxil fumarate (TDF)-containing maternal antiretroviral therapy (ART) with infant nevirapine p…
Women taking TDF-based HIV meds had larger drops in kidney function than those on infant-only treatment, but calcium and phosphate levels st…
HIV-1 resistance patterns vary by prior regimen and geographic region in this substudy
HIV drug resistance patterns vary by region and prior treatment history
This substudy examined HIV-1 drug resistance mutations in people failing first-line therapy across 14 countries.
HIV drug resistance varies by region and prior treatment. Subtype C dominates, but resistance to common drugs is high. This matters for choo…
Valacyclovir No Better Than Placebo for Stromal Keratitis in Herpes Zoster Ophthalmicus
Oral antivirals do not prevent eye inflammation in shingles patients
This secondary analysis of a randomized trial in 527 patients with herpes zoster ophthalmicus found that oral valacyclovir 1 g daily did not…
A study of 527 people with shingles eye infections found oral antivirals did not stop inflammation. Close monitoring and low-potency steroid…
Meta-analysis finds antibiotic prophylaxis reduces post-ERCP infections in biliary obstruction
Antibiotics Lower Infection Risk After ERCP Procedures
This systematic review and meta-analysis of 2105 patients found that prophylactic antibiotics significantly reduce infectious complications …
New data shows taking antibiotics before ERCP lowers infection risk for all patients with blocked bile ducts.
Meta-analysis: Nitazoxanide triple therapy improves H. pylori eradication vs standard triple therapy
Nitazoxanide triple therapy significantly improves H. pylori cure rates compared to standard treatment
This systematic review and meta-analysis of 1286 participants found that nitazoxanide-based triple therapy significantly improved H.
A large review of 1286 patients found that adding nitazoxanide to standard triple therapy significantly improved H. pylori cure rates and re…
Systematic review and meta-analysis shows cefotiam reduces postoperative infection in clean surgery
Cefotiam cuts post-surgery infection risk by half compared to no antibiotics
This systematic review and meta-analysis evaluated cefotiam prophylaxis versus no antibiotic prophylaxis or other beta-lactam agents in adul…
A large review found cefotiam lowers infection risk after clean surgery. It works as well as other common antibiotics without causing more s…