KP ST258 Clade 2 isolates linked to increased virulence in observational and mouse studies
Klebsiella Clade 2 Linked to Worse Illness in Humans and Mice
An observational study of 172 clinical KP ST258 isolates and a mouse model found that Clade 2 isolates were associated with more acute illne…
Klebsiella pneumoniae Clade 2 causes worse illness in humans and spreads more easily to organs like the liver and spleen in mice compared to…
FDA Approves Fosfomycin Tromethamine (fosfomycin tromethamine) for Uncomplicated Urinary Tract Infections in Women
FDA approves new single-dose antibiotic for treating bladder infections in women.
Fosfomycin tromethamine granules for oral solution was approved for uncomplicated urinary tract infections (acute cystitis) in women due to …
FDA approves a new single-dose antibiotic for women with bladder infections, offering a convenient one-time treatment option for common urin…
Phase 3 trial of Ad5-nCoV vaccine shows no increased short-term HIV infection risk in 44,247 participants.
Ad5 COVID Vaccine Cleared of HIV Risk in 44,247-Person Trial
This Phase 3 randomized controlled trial evaluated the association between the Ad5-nCoV vaccine and HIV infection risk in 44,247 HIV-negativ…
A decades-old worry that certain vaccine delivery systems might raise HIV risk does not apply to the Ad5 COVID vaccine, based on a trial of …
Pitavastatin showed no difference in health-related quality of life compared with placebo in people with HIV.
Why Heart Risk Factors Drag Down Daily Wellbeing for People With HIV
This randomized controlled trial evaluated pitavastatin versus placebo in 733 people with HIV aged 40 to 75 years on antiretroviral therapy …
Common heart risks like smoking and high BMI hurt daily physical wellbeing for people with HIV, while statins showed no visible improvement …
ALIS plus macrolide regimen improves culture conversion in noncavitary MAC lung disease
An Inhaled Antibiotic Shifts the Odds in a Stealthy Lung Infection
In a 99-patient RCT of adults with noncavitary MAC lung disease, adding 6 months of amikacin liposome inhalation suspension (ALIS) to a macr…
Adding a nebulized antibiotic to standard pills helped more newly diagnosed MAC lung patients clear the bug sooner, with no new safety surpr…
Meta-analysis finds 9% Shigella prevalence across human, animal, food, and environmental samples in Cameroon
Why a Common Diarrhea Bug in Cameroon Is Outsmarting First-Line Antibiotics
A systematic review and meta-analysis of 24,847 samples from Cameroon found an overall pooled Shigella prevalence of 9% (95% CI, 5.51%-14.76…
A Cameroon-wide review found Shigella infections cause about 6% of human diarrhea cases — and that the bacteria are increasingly resistant t…
DOACs reduce thromboembolic events in pediatric patients compared to standard anticoagulation
A Pill Form of Blood Thinner May Be Safer for Kids Than Standard Shots
A meta-analysis of 2,002 pediatric patients found direct oral anticoagulants (DOACs) significantly reduced thromboembolic event recurrence (…
New oral blood thinners cut dangerous blood clot recurrences in half for children without increasing bleeding risks compared to standard sho…
BV100 (rifabutin for infusion) showed dose-proportional pharmacokinetics and safety in healthy volunteers.
A New IV Drug Targets the Hardest Hospital Infections to Treat
This Phase 1 randomized controlled trial evaluated the pharmacokinetics, safety, and tolerability of BV100 (rifabutin for infusion) in healt…
A reformulated intravenous version of the antibiotic rifabutin appears safe in healthy volunteers and may give doctors a new tool for treati…
Educational or psychological interventions for parental vaccine hesitancy show mixed effectiveness across 11 studies.
Why Some Vaccine Talks Change Parents' Minds — and Others Don't
This systematic review of 11 quantitative studies evaluated educational or psychological interventions targeting parental vaccine hesitancy.…
The way parents are spoken to about vaccines matters as much as the facts they're given.
Meta-analysis of 19,941 participants shows 83.0% eradication rates for Helicobacter pylori antibiotic regimens.
How Well Today's Antibiotics Still Clear the Stomach Bug Behind Ulcers
This systematic review and meta-analysis evaluated antibiotic regimens for Helicobacter pylori eradication across 57 studies involving 19,94…
Current antibiotics clear the ulcer-causing stomach bug in about 83% of patients, meaning roughly 1 in 6 people still need a second round of…
Mini-review examines nanomaterial strategies for managing implant-associated oral biofilms
Tiny Coatings May Solve Dental Implants' Biggest Long-Term Threat
A mini-review describes multifunctional nanomaterial-based strategies for controlling peri-implantitis and oral biofilm infections, where co…
A new generation of nanomaterial-based dental implant coatings may help fight the bacterial films that cause one of the most common reasons …
Nirmatrelvir-ritonavir reduced viral production by approximately 55% in SARS-CoV-2 BA.2-infected patients in Shanghai.
Your COVID Pill May Work Better—Or Worse—Than You Think
This cohort study of 48,243 SARS-CoV-2 BA.2-infected patients in Shanghai evaluated nirmatrelvir-ritonavir exposure. The analysis indicated …
How well your Paxlovid works depends heavily on your age and vaccination status.